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Brand names,
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Analogs
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Brand Names Mixture
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Chemical_Formula
C15H12N2O2
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RX_link
http://www.rxlist.com/cgi/generic3/oxcarbazepine.htm
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fda sheet
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msds (material safety sheet)
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Synthesis Reference
No information avaliable
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Molecular Weight
252.268 g/mol
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Melting Point
215.5 oC
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H2O Solubility
308 mg/L at 25 oC (SRC PhysProp estimated -- MEYLAN,WM et al. (1996))
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State
Solid
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LogP
1.807
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Dosage Forms
Suspension; Tablet (150 mg, 300 mg and 600 mg film coated)
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Indication
For use as monotherapy or adjunctive therapy in the treatment of partial seizures in adults with epilepsy and as adjunctive therapy in the treatment of partial seizures in children ages 4-16 with epilepsy.
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Pharmacology
Oxcarbazepine is structurally a derivative of carbamazepine, adding an extra oxygen atom to the benzylcarboxamide group. This difference helps reduce the impact on the liver of metabolizing the drug, and also prevents the serious forms of anemia occasionally associated with carbamazepine. Aside from this reduction in side effects, it is thought to have the same mechanism as carbamazepine - sodium channel inhibition - and is generally used to treat the same conditions.
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Absorption
Completely absorbed following oral administration. Food has no effect on the rate and extent of absorption of oxcarbazepine.
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side effects and Toxicity
Isolated cases of overdose with oxcarbazepine have been reported. The maximum dose taken was approximately 24,000 mg. All patients recovered with symptomatic treatment.
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Patient Information
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Organisms Affected
Humans and other mammals