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Burinex Brand names, Burinex Analogs

Burinex Brand Names Mixture

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Burinex Chemical_Formula


Burinex RX_link


Burinex fda sheet

Burinex FDA

Burinex msds (material safety sheet)

Burinex MSDS

Burinex Synthesis Reference

J. Med. Chem. 14, 432 (1971)

Burinex Molecular Weight

364.417 g/mol

Burinex Melting Point

230-231 oC

Burinex H2O Solubility

>20 mg/mL (in base)

Burinex State


Burinex LogP


Burinex Dosage Forms

Tablets (0.5 and 1 mg)

Burinex Indication

For the treatment of edema associated with congestive heart failure, hepatic and renal disease including the nephrotic syndrome.

Burinex Pharmacology

Bumetanide is a loop diuretic of the sulfamyl category to treat heart failure. It is often used in patients in whom high doses of furosemide are ineffective. There is however no reason not to use bumetanide as a first choice drug. The main difference between the two substances is in bioavailability. It is said to be a more predictable diuretic, meaning that the predictable absorption is reflected in a more predictable effect. Bumetanide is 40 times more potent than furosemide (for patients with normal renal function).

Burinex Absorption

Bumetanide is completely absorbed (80%), and the absorption is not altered when taken with food. Bioavailability is almost complete.

Burinex side effects and Toxicity

Overdosage can lead to acute profound water loss, volume and electrolyte depletion, dehydration, reduction of blood volume and circulatory collapse with a possibility of vascular thrombosis and embolism. Electrolyte depletion may be manifested by weakness, dizziness, mental confusion, anorexia, lethargy, vomiting and cramps. Treatment consists of replacement of fluid and electrolyte losses by careful monitoring of the urine and electrolyte output and serum electrolyte levels.

Burinex Patient Information

Bumetanide, a 'water pill,' is used to reduce the swelling and fluid retention caused by various medical problems, including heart or liver disease. It also is used to treat high blood pressure. It causes the kidneys to get rid of unneeded water and salt from the body into the urine. Bumetanide comes as a tablet to take by mouth. It usually is taken once a day, in the morning. Before taking bumetanide,
tell your doctor and pharmacist if you are allergic to bumetanide, sulfa drugs, or any other drugs.
tell your doctor and pharmacist what prescription and nonprescription medications you are taking, especially other medications for high blood pressure, corticosteroids (e.g., prednisone), digoxin (Lanoxin), indomethacin (Indocin), lithium (Eskalith, Lithobid), probenecid (Benemid), and vitamins.
tell your doctor if you have or have ever had diabetes, gout, or kidney or liver problems.
tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. Do not breast-feed while taking this medicine. If you become pregnant while taking bumetanide, call your doctor.
if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking bumetanide

Burinex Organisms Affected

Humans and other mammals