Azatadine
Brand names,
Azatadine
Analogs
Azatadine
Brand Names Mixture
- Actinac Pwr (Allantoin + Butoxyethyl Nicotinate + Chloramphenicol + Hydrocortisone Acetate + Sulfur)
- Actinac Pws (Allantoin + Butoxyethyl Nicotinate + Chloramphenicol + Hydrocortisone Acetate + Sulfur)
- Calmurid Hc Crm (Hydrocortisone + Urea)
- Cortisporin (Bacitracin Zinc + Hydrocortisone + Neomycin Sulfate + Polymyxin B Sulfate)
- Eye and Wound Powder (Chlorhexidine Hydrochloride + Hydrocortisone Acetate + Penicillin G Procaine + Sulfathiazole)
- Forte Topical Suspension (Hydrocortisone Acetate + Hydrocortisone Sodium Succinate + Neomycin (Neomycin Sulfate) + Penicillin G Procaine + Polymyxin B Sulfate)
- Neo-Cortef Eye Ear Dps (Hydrocortisone Acetate + Neomycin Sulfate)
- Neo-Cortef Eye Ear Drops Sterile Suspension (Hydrocortisone Acetate + Neomycin Sulfate)
- Neo-Cortef Eye Ear Ont (Hydrocortisone Acetate + Neomycin Sulfate)
- Ophthocort Ont (Chloramphenicol + Hydrocortisone Acetate + Polymyxin B (Polymyxin B Sulfate))
- Otizol Hc Liq (Hydrocortisone (Hydrocortisone Acetate) + Lidocaine (Lidocaine Hydrochloride) + Neomycin (Neomycin Sulfate))
- Proctosedyl Ointment (Dibucaine Hydrochloride + Esculin + Framycetin Sulfate + Hydrocortisone)
- Proctosedyl Sup (Dibucaine Hydrochloride + Esculin + Framycetin Sulfate + Hydrocortisone)
- Proctosedyl Suppositories (Dibucaine Hydrochloride + Esculin + Framycetin Sulfate + Hydrocortisone)
- Proctosone Ont (Dibucaine Hydrochloride + Esculin + Hydrocortisone Acetate + Neomycin Sulfate)
- Proctosone Sup (Dibucaine Hydrochloride + Esculin + Hydrocortisone Acetate + Neomycin Sulfate)
- Sopamycetin/Hc Ointment (Chloramphenicol + Hydrocortisone Acetate)
- Sopamycetin/Hc Ont (Chloramphenicol + Hydrocortisone Acetate)
- Sopamycetin/Hc Susp (Chloramphenicol + Hydrocortisone Acetate)
- Ti-U-Lac Hc Lotion (Hydrocortisone + Urea)
- Vioform + Hydrocortisone (Clioquinol + Hydrocortisone)
- Vioform Hydrocortisone Cream (Clioquinol + Hydrocortisone)
- Vioform Hydrocortisone Mild (Clioquinol + Hydrocortisone)
- Vosol Hc (Acetic Acid + Benzethonium Chloride + Hydrocortisone + Propylene Glycol Diacetate)
Azatadine
Chemical_Formula
C20H22N2
Azatadine
RX_link
http://www.rxlist.com/cgi/generic3/azatpseud.htm
Azatadine
fda sheet
Azatadine
msds (material safety sheet)
Azatadine
Synthesis Reference
No information avaliable
Azatadine
Molecular Weight
290.402 g/mol
Azatadine
Melting Point
No information avaliable
Azatadine
H2O Solubility
Very soluble
Azatadine
State
Solid
Azatadine
LogP
2.927
Azatadine
Dosage Forms
Tablet
Azatadine
Indication
For the relief of the symptoms of upper respiratory mucosal congestion in perennial and allergic rhinitis, and for the relief of nasal congestion and eustachian t.b. congestion.
Azatadine
Pharmacology
Azatadine is an antihistamine, related to cyproheptadine, with anti-serotonin, anticholinergic (drying), and sedative effects. Azatadine is in the same class of drugs as chlorpromazine (Thorazine) and trifluoperazine (Stelazine); however, unlike the other drugs in this class, azatadine is not used clinically as an anti-psychotic. Antihistamines antagonize the vasodilator effect of endogenously released histamine, especially in small vessels, and mitigate the effect of histamine which results in increased capillary permeability and edema formation. As consequences of these actions, antihistamines antagonize the physiological manifestations of histamine release in the nose following antigen-antibody interaction, such as congestion related to vascular engorgement, mucosal edema, and profuse, watery secretion, and irritation and sneezing resulting from histamine action on afferent nerve terminals.
Azatadine
Absorption
Well absorbed after oral administration.
Azatadine
side effects and Toxicity
The oral LD50 in mature rats and mice was greater than 1700 mg/kg and 600 mg/kg, respectively. Symptoms of overdose include clumsiness or unsteadiness, seizures, severe drowsiness, flushing or redness of face, hallucinations, muscle spasms (especially of neck and back), restlessness, shortness of breath, shuffling walk, tic-like (jerky) movements of head and face, trembling and shaking of hands, and insomnia.
Azatadine
Patient Information
Azatadine
Organisms Affected
Humans and other mammals