Aricept ODT
Aricept ODT Brand names, Aricept ODT Analogs
Aricept ODT Brand Names Mixture
- No information avaliable
Aricept ODT Chemical_Formula
C24H29NO3
Aricept ODT RX_link
http://www.rxlist.com/cgi/generic/donepezil.htm
Aricept ODT fda sheet
Aricept ODT msds (material safety sheet)
Aricept ODT Synthesis Reference
No information avaliable
Aricept ODT Molecular Weight
379.492 g/mol
Aricept ODT Melting Point
206.72 oC
Aricept ODT H2O Solubility
2.931 mg/L
Aricept ODT State
Solid
Aricept ODT LogP
4.09
Aricept ODT Dosage Forms
Tablet; Tablet (orally disintegrating)
Aricept ODT Indication
For management of symptoms associated with Alzheimer's Disease
Aricept ODT Pharmacology
Donepezil is a centrally acting reversible acetyl cholinesterase inhibitor. Its main therapeutic use is in the treatment of Alzheimer's disease where it is used to increase cortical acetylcholine. It is well absorbed in the gut with an oral bioavailability of 100% and easily crosses the blood-brain barrier. Because it has a half life of about 70 hours, it can be taken once a day. Initial dose is 5 mg per day, which can be increased to 10 mg per day after an adjustment period of at least 4 weeks. Donepezil is a parasympathomimetic, specifically, a reversible cholinesterase inhibitor. Donepezil is postulated to exert its therapeutic effect by enhancing cholinergic function. This is accomplished by increasing the concentration of acetylcholine through reversible inhibition of its hydrolysis by acetylcholinesterase. If this proposed mechanism of action is correct, donepezil's effect may lessen as the disease process advances and fewer cholinergic neurons remain functionally intact. There is no evidence that donepezil alters the course of the underlying dementing process.
Aricept ODT Absorption
Donepezil is well absorbed with a relative oral bioavailability of 100% and reaches peak plasma concentrations in 3 to 4 hours.
Aricept ODT side effects and Toxicity
Symptoms of overdose include severe nausea, vomiting, salivation, sweating, bradycardia, hypotension, respiratory depression, collapse and convulsions. Increasing muscle weakness is a possibility and may result in death if respiratory muscles are involved.
Aricept ODT Patient Information
Patient Info
ARICEPT� (donepezil HCl) is indicated for the treatment of symptoms of mild to moderate Alzheimer�s disease.
ARICEPT� (donepezil HCl) is well tolerated but may not be for everyone. Some people may experience nausea, diarrhea, insomnia, vomiting, muscle cramps, fatigue or loss of appetite. In studies, these side effects were usually mild and temporary. Some people taking ARICEPT� (donepezil HCl) may experience fainting. People at risk for ulcers should tell their doctors because their condition may get worse.
ARICEPT� (donepezil HCl) is indicated for the treatment of symptoms of mild to moderate Alzheimer�s disease.
ARICEPT� (donepezil HCl) is well tolerated but may not be for everyone. Some people may experience nausea, diarrhea, insomnia, vomiting, muscle cramps, fatigue or loss of appetite. In studies, these side effects were usually mild and temporary. Some people taking ARICEPT� (donepezil HCl) may experience fainting. People at risk for ulcers should tell their doctors because their condition may get worse.
Aricept ODT Organisms Affected
Humans and other mammals
