Argatroban
Argatroban Brand names, Argatroban Analogs
Argatroban Brand Names Mixture
- No information avaliable
Argatroban Chemical_Formula
C23H36N6O5S
Argatroban RX_link
http://www.rxlist.com/cgi/generic2/argatroban.htm
Argatroban fda sheet
Argatroban msds (material safety sheet)
Argatroban Synthesis Reference
No information avaliable
Argatroban Molecular Weight
508.635 g/mol
Argatroban Melting Point
No information avaliable
Argatroban H2O Solubility
No information avaliable
Argatroban State
Solid
Argatroban LogP
0.749
Argatroban Dosage Forms
Solution
Argatroban Indication
For prophylaxis or treatment of thrombosis in patients with heparin-induced thrombocytopenia
Argatroban Pharmacology
Argatroban is a synthetic direct thrombin inhibitor derived from L-arginine indicated as an anticoagulant for prophylaxis or treatment of thrombosis in patients with heparin-induced thrombocytopenia. Argatroban is a direct thrombin inhibitor that reversibly binds to the thrombin active site. Argatroban does not require the co-factor antithrombin III for antithrombotic activity. Argatroban exerts its anticoagulant effects by inhibiting thrombin-catalyzed or -induced reactions, including fibrin formation; activation of coagulation factors V, VIII, and XIII; protein C; and platelet aggregation. Argatroban is highly selective for thrombin with an inhibitory constant (Ki) of 0.04 µM. At therapeutic concentrations, Argatroban has little or no effect on related serine proteases (trypsin, factor Xa, plasmin, and kallikrein).
Argatroban Absorption
No information avaliable
Argatroban side effects and Toxicity
No information avaliable
Argatroban Patient Information
No information avaliable
Argatroban Organisms Affected
Humans and other mammals
