Amipramidin
Brand names,
Amipramidin
Analogs
Amipramidin
Brand Names Mixture
- Blu Kote Dr Naylors (Acriflavine + Gentian Violet + Glycerine + Isopropyl Alcohol + Sodium Propionate + Urea)
- Blue Lotion (Gentian Violet + Methylene Blue + Tannic Acid)
- Co-Op Pinkeye Spray (Gentian Violet + Neomycin (Neomycin Sulfate))
- Cristisol (Acriflavine + Gentian Violet + Isopropyl Alcohol)
- Pink Eye Guard (Allantoin + Boric Acid + Gentian Violet)
- Pink Eye Spray (Furfural + Gentian Violet + Isopropyl Alcohol + Methylene Blue + Phenylmercuric Nitrate (Basic) + Tetrahydrofurfuryl Alcohol + Urea)
- Pinkeye Spray (Gentian Violet + Neomycin (Neomycin Sulfate))
- Triple Dye (Brilliant Green + Gentian Violet + Proflavine Hemisulfate)
- Wound & Pinkeye Spray (Gentian Violet + Neomycin (Neomycin Sulfate))
- Wound Kote Gentian Violet Spray Wound Dre (Acriflavine + Furfural + Methyl Violet + Sodium Propionate + Urea)
Amipramidin
Chemical_Formula
C6H8ClN7O
Amipramidin
RX_link
http://www.rxlist.com/cgi/generic2/amilor.htm
Amipramidin
fda sheet
Amipramidin
msds (material safety sheet)
Amipramidin
Synthesis Reference
Cragoe, Belg, pat. 639,386 (1964 to Merck & Co.), C.A. 62, 14698f (1965)
Amipramidin
Molecular Weight
229.627 g/mol
Amipramidin
Melting Point
240 oC
Amipramidin
H2O Solubility
Slightly soluble
Amipramidin
State
Solid
Amipramidin
LogP
-1.245
Amipramidin
Dosage Forms
Tablets (oral, 5mg)
Amipramidin
Indication
For use as adjunctive treatment with thiazide diuretics or other kaliuretic-diuretic agents in congestive heart failure or hypertension.
Amipramidin
Pharmacology
Amiloride, an antikaliuretic-diuretic agent, is a pyrazine-carbonyl-guanidine that is unrelated chemically to other known antikaliuretic or diuretic agents. It is an antihypertensive, potassium-sparing diuretic that was first approved for use in 1967 and helps to treat hypertension and congestive heart failure. The drug is often used in conjunction with thiazide or loop diuretics. Due to its potassium-sparing capacities, hyperkalemia (high blood potassium levels) are occasionally observed in patients taking amiloride. The risk is high in concurrent use of ACE inhibitors or spironolactone. Patients are also advised not to use potassium-containing salt replacements.
Amipramidin
Absorption
Readily absorbed following oral administration.
Amipramidin
side effects and Toxicity
No data are available in regard to overdosage in humans. The oral LD50 of amiloride hydrochloride (calculated as the base) is 56 mg/kg in mice and 36 to 85 mg/kg in rats, depending on the strain. The most likely signs and symptoms to be expected with overdosage are dehydration and electrolyte imbalance.
Amipramidin
Patient Information
No information avaliable
Amipramidin
Organisms Affected
Humans and other mammals