Sertaconazolum_[Latin]

Category

Sertaconazolum_[Latin]




Useful info

Sertaconazolum_[Latin] Brand names, Sertaconazolum_[Latin] Analogs

Sertaconazolum_[Latin] Brand Names Mixture

  • No information avaliable

    • Sertaconazolum_[Latin] Chemical_Formula

    C20H15Cl3N2OS

    Sertaconazolum_[Latin] RX_link

    http://www.rxlist.com/cgi/generic3/ertaczo.htm

    Sertaconazolum_[Latin] fda sheet

    Sertaconazolum_[Latin] FDA

    Sertaconazolum_[Latin] msds (material safety sheet)

    Sertaconazolum_[Latin] Synthesis Reference

    No information avaliable

    Sertaconazolum_[Latin] Molecular Weight

    437.77 g/mol

    Sertaconazolum_[Latin] Melting Point

    No information avaliable

    Sertaconazolum_[Latin] H2O Solubility

    Practically insoluble

    Sertaconazolum_[Latin] State

    Solid

    Sertaconazolum_[Latin] LogP

    5.952

    Sertaconazolum_[Latin] Dosage Forms

    Cream (2% contains 17.5 mg of sertaconazole)

    Sertaconazolum_[Latin] Indication

    For the topical treatment of interdigital tinea pedis in immunocompetent patients 12 years of age and older, caused by Trichophyton rubrum, Trichophyton mentagrophytes, and Epidermophyton floccosum.

    Sertaconazolum_[Latin] Pharmacology

    Sertaconazole is an imidazole/triazole type antifungal agent. Sertaconazole is a highly selective inhibitor of fungal cytochrome P-450 sterol C-14 α-demethylation via the inhibition of the enzyme cytochrome P450 14α-demethylase. This enzyme converts lanosterol to ergosterol, and is required in fungal cell wall synthesis. The subsequent loss of normal sterols correlates with the accumulation of 14 α-methyl sterols in fungi and may be partly responsible for the fungistatic activity of fluconazole. Mammalian cell demethylation is much less sensitive to fluconazole inhibition. Sertaconazole exhibits in vitro activity against Cryptococcus neoformans and Candida spp. Fungistatic activity has also been demonstrated in normal and immunocompromised animal models for systemic and intracranial fungal infections due to Cryptococcus neoformans and for systemic infections due to Candida albicans.

    Sertaconazolum_[Latin] Absorption

    No information avaliable

    Sertaconazolum_[Latin] Toxicity

    No information avaliable

    Sertaconazolum_[Latin] Patient Information

    The patient should be instructed to:
    1. Use Sertaconazole Cream, 2%, as directed by the physician. The hands should be washed after applying the medication to the affected area(s). Avoid contact with the eyes, nose, mouth and other mucous membranes. Sertaconazole Cream, 2%, is for external use only.
    2. Dry the affected area(s) thoroughly before application, if you wish to use Sertaconazole Cream, 2%, after bathing.
    3. Use the medication for the full treatment time recommended by the physician, even though symptoms may have improved. Notify the physician if there is no improvement after the end of the prescribed treatment period, or sooner, if the condition worsens.
    4. Inform the physician if the area of application shows signs of increased irritation, redness, itching, burning, blistering, swelling or oozing.
    5. Avoid the use of occlusive dressings unless otherwise directed by the physician.
    6. Do not use this medication for any disorder other than that for which it was prescribed.

    Sertaconazolum_[Latin] Organisms Affected

    Yeast and other fungi