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Prexan
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Prexan Brand names, Prexan Analogs

Prexan Brand Names Mixture

  • No information avaliable

Prexan Chemical_Formula

C4H6CaO4

Prexan RX_link

No information avaliable

Prexan fda sheet

Prexan FDA

Prexan msds (material safety sheet)

Prexan MSDS

Prexan Synthesis Reference

No information avaliable

Prexan Molecular Weight

158.17 g/mol

Prexan Melting Point

> 160 oC

Prexan H2O Solubility

No information avaliable

Prexan State

Solid

Prexan LogP

No information avaliable

Prexan Dosage Forms

Capsule; Drops; Liquid; Powder for solution; Solution; Tablet

Prexan Indication

Used to treat hyperphosphatemia (too much phosphate in the blood) in patients with kidney disease.

Prexan Pharmacology

Patients with advanced renal insufficiency (creatinine clearance less than 30 ml/min) exhibit phosphate retention and some degree of hyperphosphatemia. The retention of phosphate plays a pivotal role in causing secondary hyperparathyroidism associated with osteodystrophy, and soft-tissue calcification. The mechanism by which phosphate retention leads to hyperparathyroidism is not clearly delineated. Therapeutic efforts directed toward the control of hyperphosphatemia include reduction in the dietary intake of phosphate, inhibition of absorption of phosphate in the intestine with phosphate binders, and removal of phosphate from the body by more efficient methods of dialysis. The rate of removal of phosphate by dietary manipulation or by dialysis is insufficient. Dialysis patients absorb 40% to 80% of dietary phosphorus. Therefore, the fraction of dietary phosphate absorbed from the diet needs to be reduced by using phosphate binders in most renal failure patients on maintenance dialysis. Calcium acetate when taken with meals combines with dietary phosphate to form insoluble calcium phosphate which is excreted in the feces. Maintenance of serum phosphorus below 6.0 mg/dl is generally considered as a clinically acceptable outcome of treatment with phosphate binders. Calcium acetate is highly soluble at neutral pH, making the calcium readily available for binding to phosphate in the proximal small intestine.

Prexan Absorption

40% is absorbed in the fasting state and approximately 30% is absorbed in the nonfasting state following oral administration.

Prexan side effects and Toxicity

Oral, rat: LD50 = 4280 mg/kg. Symptoms of overdose include mild hypercalcemia (constipation; loss of appetite; nausea and vomiting), and severe hypercalcemia (confusion; full or partial loss of consciousness; incoherent speech).

Prexan Patient Information

No information avaliable

Prexan Organisms Affected

Humans and other mammals