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Napren Brand names, Napren Analogs

Napren Brand Names Mixture

  • No information avaliable

Napren Chemical_Formula


Napren RX_link

No information avaliable

Napren fda sheet

Napren FDA

Napren msds (material safety sheet)

Napren MSDS

Napren Synthesis Reference

No information avaliable

Napren Molecular Weight

158.17 g/mol

Napren Melting Point

> 160 oC

Napren H2O Solubility

No information avaliable

Napren State


Napren LogP

No information avaliable

Napren Dosage Forms

Capsule; Drops; Liquid; Powder for solution; Solution; Tablet

Napren Indication

Used to treat hyperphosphatemia (too much phosphate in the blood) in patients with kidney disease.

Napren Pharmacology

Patients with advanced renal insufficiency (creatinine clearance less than 30 ml/min) exhibit phosphate retention and some degree of hyperphosphatemia. The retention of phosphate plays a pivotal role in causing secondary hyperparathyroidism associated with osteodystrophy, and soft-tissue calcification. The mechanism by which phosphate retention leads to hyperparathyroidism is not clearly delineated. Therapeutic efforts directed toward the control of hyperphosphatemia include reduction in the dietary intake of phosphate, inhibition of absorption of phosphate in the intestine with phosphate binders, and removal of phosphate from the body by more efficient methods of dialysis. The rate of removal of phosphate by dietary manipulation or by dialysis is insufficient. Dialysis patients absorb 40% to 80% of dietary phosphorus. Therefore, the fraction of dietary phosphate absorbed from the diet needs to be reduced by using phosphate binders in most renal failure patients on maintenance dialysis. Calcium acetate when taken with meals combines with dietary phosphate to form insoluble calcium phosphate which is excreted in the feces. Maintenance of serum phosphorus below 6.0 mg/dl is generally considered as a clinically acceptable outcome of treatment with phosphate binders. Calcium acetate is highly soluble at neutral pH, making the calcium readily available for binding to phosphate in the proximal small intestine.

Napren Absorption

40% is absorbed in the fasting state and approximately 30% is absorbed in the nonfasting state following oral administration.

Napren side effects and Toxicity

Oral, rat: LD50 = 4280 mg/kg. Symptoms of overdose include mild hypercalcemia (constipation; loss of appetite; nausea and vomiting), and severe hypercalcemia (confusion; full or partial loss of consciousness; incoherent speech).

Napren Patient Information

No information avaliable

Napren Organisms Affected

Humans and other mammals