PharmacyCodes



Colestipolum [INN-Latin] en es it fr

Colestipolum [INN-Latin] Brand names, Colestipolum [INN-Latin] Analogs

Colestipolum [INN-Latin] Brand Names Mixture

  • No information avaliable

Colestipolum [INN-Latin] Chemical_Formula

C25H48N6O8

Colestipolum [INN-Latin] RX_link

No information avaliable

Colestipolum [INN-Latin] fda sheet

Colestipolum [INN-Latin] msds (material safety sheet)

Colestipolum_[INN-Latin] MSDS

Colestipolum [INN-Latin] Synthesis Reference

No information avaliable

Colestipolum [INN-Latin] Molecular Weight

560.684 g/mol

Colestipolum [INN-Latin] Melting Point

138-140oC

Colestipolum [INN-Latin] H2O Solubility

1.2 mg/mL (at 20°C, 1.2%)

Colestipolum [INN-Latin] State

Solid

Colestipolum [INN-Latin] LogP

-0.478

Colestipolum [INN-Latin] Dosage Forms

Powder (vials of 500 mg or 2 g sterile powder for preparing injections or for oral use)

Colestipolum [INN-Latin] Indication

Used to treat acute iron or aluminum toxicity (an excess of aluminum in the body) in certain patients. Also used in certain patients with anemia who must receive many blood transfusions.

Colestipolum [INN-Latin] Pharmacology

Deferoxamine, otherwise known as desferrioxamine or desferal, is a chelating agent used to remove excess iron or aluminum from the body. It acts by binding free iron or aluminum in the bloodstream and enhancing its elimination in the urine. By removing excess iron or aluminum, the agent reduces the damage done to various organs and tissues, such as the liver.

Colestipolum [INN-Latin] Absorption

Deferoxamine is rapidly absorbed after intramuscular or subcutaneous administration, but only poorly absorbed from the gastrointestinal tract in the presence of intact mucosa.

Colestipolum [INN-Latin] side effects and Toxicity

Intravenous LD50 in mouse, rat, and rabbit is 340 mg/kg, 520 mg/kg, and 600 mg/kg, respectively. Subcutaneous LD50 in mouse and rat is 1600 mg/kg and >1000 mg/kg, respectively. Oral LD50 in mouse and rat is >3000 mg/kg and >1000 mg/kg, respectively. Nephrotoxicity, ototoxicity and retinal toxicity have been reported following long-term administration for chronic iron overload.

Colestipolum [INN-Latin] Patient Information

Colestipolum [INN-Latin] Organisms Affected

Humans and other mammals