Acitretin
Acitretin Brand names, Acitretin Analogs
Acitretin Brand Names Mixture
- No information avaliable
Acitretin Chemical_Formula
C21H26O3
Acitretin RX_link
http://www.rxlist.com/cgi/generic3/acitretin.htm
Acitretin fda sheet
Acitretin msds (material safety sheet)
Acitretin Synthesis Reference
No information avaliable
Acitretin Molecular Weight
326.429 g/mol
Acitretin Melting Point
228-230 oC
Acitretin H2O Solubility
0.0729 mg/L
Acitretin State
Solid
Acitretin LogP
4.84
Acitretin Dosage Forms
10 mg and 25 mg gelatin capsules for oral administration
Acitretin Indication
For the treatment of severe psoriasis in adults.
Acitretin Pharmacology
Acitretin is a retinoid. Retinoids have a structure similar to vitamin A and are involved in the normal growth of skin cells. Acitretin works by inhibiting the excessive cell growth and keratinisation (process by which skin cells become thickened due to the deposition of a protein within them) seen in psoriasis. It therefore reduces the thickening of the skin, plaque formation and scaling.
Acitretin Absorption
Oral absorption of acitretin is optimal when given with food, and is linear and proportional with increasing doses from 25 to 100 mg. Approximately 72% (range 47% to 109%) of the administered dose was absorbed after a single 50 mg dose of acitretin was given to 12 healthy subjects.
Acitretin side effects and Toxicity
Oral, rat: LD50 = >4000 mg/kg. Symptoms of overdose include headache and vertigo.
Acitretin Patient Information
Acitretin Organisms Affected
Humans and other mammals
