AHR_85
Category
AHR_85 Brand names, AHR_85 Analogs
AHR_85 Brand Names Mixture
No information avaliable
AHR_85 Chemical_Formula
C14H14N2O
AHR_85 RX_link
http://www.rxlist.com/cgi/generic3/metopirone.htm
AHR_85 fda sheet
AHR_85 msds (material safety sheet)
AHR_85 Synthesis Reference
No information avaliable
AHR_85 Molecular Weight
226.274 g/mol
AHR_85 Melting Point
50.5 oC
AHR_85 H2O Solubility
Sparingly soluble
AHR_85 State
Solid
AHR_85 LogP
2.303
AHR_85 Dosage Forms
Capsules for oral administration (250 mg)
AHR_85 Indication
Used as a diagnostic drug for testing hypothalamic-pituitary ACTH function.
AHR_85 Pharmacology
Metopirone is an inhibitor of endogenous adrenal corticosteroid synthesis.
AHR_85 Absorption
Absorbed rapidly and well when administered orally. Peak plasma concentrations are usually reached 1 hour after administration.
AHR_85 Toxicity
Oral LD50 in rats is 521 mg/kg. One case has been recorded in which a 6-year-old girl died after two doses of Metopirone, 2 g. Symptoms of overdose include cardiac arrhythmias, hypotension, dehydration, anxiety, confusion, weakness, impairment of consciousness, nausea, vomiting, epigastric pain, and diarrhea.
AHR_85 Patient Information
AHR_85 Organisms Affected
Humans and other mammals
