Safety (MSDS) data for cisplatin

Safety (MSDS) data for cisplatin

Hazard: Toxic


    Synonyms: cis-dichlorodiammineplatinum (II), cis-diaminedichloroplatinum (II), cis-diamminedichloroplatinum (II), CPDD, CDDP, CACP, CPDC, DDP, DDPt, cis-ddp, neoplatin, platinol, dCDP, cis-platinous diamine dichloride, (SP-4-2)-diaminedichloroplatinum, cis-platinum(II) diamine dichloride, cisplatyl, platiblastin, PT01, Peyrone's chloride, NSC-119875, cispt(II)
    Use: anti-tumor agent, antineoplastic
    Molecular formula: Pt(NH3)2Cl2
    CAS No: 15663-27-1
    EINECS No:

Physical data

    Appearance: yellow crystalline solid
    Melting point: ca. 270 (decomposes)
    Boiling point:
    Vapour density:
    Vapour pressure:
    Density (g cm-3):
    Flash point:
    Explosion limits:
    Autoignition temperature:
    Water solubility: negligible


    Stable. Incompatible with oxidizing agents, aluminium, antioxidants.


    Very toxic if inhaled, swallowed, or absorbed through the skin. Many platinum compounds are sensitizers, so even low exposure may be harmful if taking place repeatedly or over an extended period. Experimental carcinogen, teratogen. IARC probable human carcinogen. May cause reproductive damage. Human mutagenic data. May cause severe allergic reaction, which may get worse with continuing exposure.

    Toxicity data
    (The meaning of any toxicological abbreviations which appear in this section is given here.)
    IVN-HMN TDLO 72 mg kg-1/25d/i
    ORL-RAT LD50 25 mg kg-1
    IPR-RAT LD50 7 mg kg-1
    SCU-RAT LD50 8 mg kg-1
    IVN-DOG LD50 2.5 mg kg-1
    IVN-MUS LD50 11 mg kg-1

    Risk phrases
    (The meaning of any risk phrases which appear in this section is given here.)
    R23 R24 R25 R36 R37 R38 R45 R46 R60.

Transport information

    (The meaning of any UN hazard codes which appear in this section is given here.)
    Non-hazardous for air, sea and road freight.

Personal protection

    Safety glasses, gloves, good ventilation. Treat as a possible carcinogen.

    Safety phrases
    (The meaning of any safety phrases which appear in this section is given here.)
    S20 S22 S23 S24 S26 S27 S28 S36 S37 S45 S53.

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This information was last updated on September 5, 2003. We have tried to make it as accurate and useful as possible, but can take no responsibility for its use, misuse, or accuracy. We have not verified this information, and cannot guarantee that it is up-to-date.