Tobramycin Base

BRISTOL MYERS SQUIBB -- TOBRAMYCIN SULFATE INJECTION 10MG/ML, 40 MG/ML -- -
=====================  Product Identification  =====================

Product ID:TOBRAMYCIN SULFATE INJECTION 10MG/ML, 40 MG/ML
MSDS Date:05/14/1992
FSC:NIIN:Submitter:F BT
Status Code:A
MSDS Number: CJKGF
=== Responsible Party ===
Company Name:BRISTOL MYERS SQUIBB
Box:191
City:NEW BRUNSWICK
State:NJ
ZIP:08903
Country:US
Info Phone Num:201-519-2885
Emergency Phone Num:908-519-2385
CAGE:IO660
=== Contractor Identification ===
Company Name:BRISTOL MYERS SQUIBB
Box:191
City:NEW BRUNSWICK
State:NJ
ZIP:08903
Country:US
Phone:201-519-2885
CAGE:IO660

=============  Composition/Information on Ingredients  =============

Ingred Name:TOBRAMYCIN SULFATE
CAS:49842-07-1
Minumum % Wt:1.
Maxumum % Wt:4.

Ingred Name:WATER
CAS:7732-18-5
RTECS #:ZC0110000
> Wt:1.

Ingred Name:PHENOL
< Wt:1.

Ingred Name:SODIUM METABISULFITE
CAS:7681-57-4
RTECS #:UX8225000
< Wt:1.
ACGIH TLV:5 MG/M3

Ingred Name:EDETATE DISODIUM
CAS:139-33-3
RTECS #:AH4375000
< Wt:1.

Ingred Name:SULFURIC ACID
CAS:7664-93-9
RTECS #:WS5600000
< Wt:1.
OSHA PEL:1 MG/M3
ACGIH TLV:1 MG/M3
ACGIH STEL:3 MG/M3
EPA Rpt Qty:1000 LBS
DOT Rpt Qty:1000 LBS

Ingred Name:SODIUM HYDROXIDE
CAS:1310-73-2
RTECS #:WB4900000
< Wt:1.
OSHA PEL:2 MG/M3
ACGIH STEL:C2 MG/M3
EPA Rpt Qty:1000 LBS
DOT Rpt Qty:1000 LBS

=====================  Hazards Identification  =====================

LD50 LC50 Mixture:ORAL LD50(MOUSE): >10,500 MG/KG
Routes of Entry: Inhalation:UNKNOWN  Skin:YES  Ingestion:YES
Health Hazards Acute and Chronic:TOBRAMYCIN SULFATE INJECTION CONTAINS
    A POTENT AMINOGLYCOSIDE ANTIBIOTIC DRUG. IT IS INTENDED FOR
    INTRAMUSCULAR/INTRAVENOUS INJECTION, UNDER THE CARE OF A PHYSICIAN.
    ORALLY AMINOGLYCOSIDES ARE POORLY  ABSORBED FROM THE GI TRACT.
    ABSORPTION MAY OCCUR FROM LARGE DOSES TO WOUNDS/DENUDED SKIN/BURNS
    MAY RESULT IN SYSTEMIC TOXICITY. ALLERGIC REACTION MAY OCCUR. EYES:
    INFLAMMATION OF CONJUNCTIVA. MAY AFFE CT KIDNEYS, CAUSE
    NEUROMUSCULAR DISORDERS. MAY AFFECT THE EARS (EIGHTH RANIAL NERVE)
    & NERVOUS SYSTEM.
Effects of Overexposure:NAUSEA, VOMITING, DIARRHEA, ALTERED ABSORPTION
    OF NUTRIENTS & ELECTROLYTE DISTURBANCES, RASH, URTICARIA,
    STOMATITIS, PRURITUS, BURNING, FEVER, EOSINOPHILIA, HEARING LOSS,
    NEUROMUSCULAR BLOCKADE, INFLA MMATION, REDNESS, ITCHING,
    IRRITATION.
Medical Cond Aggravated by Exposure:IMPAIRED HEARING, KIDNEY DISORDERS,
    NEUROMUSCULAR DISORDERS, ALLERGIES TO AMINOGLYCOSIDES.

=======================  First Aid Measures  =======================

First Aid:EYES: FLUSH W/LARGE AMOUNTS OF WATER FOR 15-20 MINS. SKIN:
    WASH W/SOAP & WATER FOR 15-20 MINS. INHALATION: REMOVE TO FRESH
    AIR; GIVE OXYGEN/CPR IF NECESSARY. OBTAIN MEDICAL ATTENTION IN ALL
    CASES.

=====================  Fire Fighting Measures  =====================

Extinguishing Media:USE WATER
Fire Fighting Procedures:EVACUATE PERSONNEL TO SAFE AREA. USE A SELF
    CONTAINED BREATHING APPARATUS & FULL PROTECTIVE CLOTHING. USE WATER
    TO KEEP FIRE-EXPOSED COTNAINERS COOL. FIGHT FIRE FROM MAXIMUM
    DISTANCE. DIVERT RUNOFF TO	A SAFE AREA.

==================  Accidental Release Measures  ==================

Spill Release Procedures:WEARING SUITABLE PROTECTIVE CLOTHING, ABSORB
    LIQUID ONTO ABSORBENT MATERIAL & PLACE INTO A CONTAINER FOR
    DISPOSAL. THE AREA SHOULD BE VENTILATED & DECONTAMINATED AFTER
    MATERIAL HAS BEEN PICKED UP.

======================	Handling and Storage  ======================

Handling and Storage Precautions:STORE AT ROOM TEMPERATURE. PERSONNEL
    WHO HANDLE THIS SOLUTION IN A MANUFACTURING FACILITY SHOULD WEAR
    PROTECTIVE CLOTHING, IMPERMEABLE GLOVES, EYE PROTECTION & A GOWN.
    PERSONNEL WHO HANDLE THIS SOLUTI ON IN A NON-MANUFACTURING
    SETTING/CLINICAL FACILITY SHOULD WEAR IMPERMEABLE GLOVES & EYE
    PROTECTION.
Other Precautions:PERSONS WHO ARE ALLERGIC TO TOBRAMYCIN SULFATE/OTHER
    AMINOGLYCOSIDES SHOULD AVOID CONTACT W/THIS SUBSTANCE. THERAPEUTIC
    AGENTS ARE INTENDED FOR USE UNDER DIRECTION OF A PHYSICIAN/UNDER
    THE CONDITIONS  OF USE DESCRIBED ON THE LABEL. PERSONNEL HANDLING
    DRUG SUBSTANCES SHOULD AVOID CONTACT W/THESE SUBST ANCES.

=============  Exposure Controls/Personal Protection  =============

Respiratory Protection:REQUIRED
Ventilation:REQUIRED
Protective Gloves:IMPERMEABLE
Eye Protection:REQUIRED
Other Protective Equipment:GOWN, PROTECTIVE CLOTHING
Supplemental Safety and Health

==================  Physical/Chemical Properties  ==================

Boiling Pt:=100.C, 212.F
Melt/Freeze Pt:=0.C, 32.F
Vapor Pres:AS WATER
pH:5.7-5.8
Solubility in Water:MISCIBLE
Appearance and Odor:CLEAR, COLORLESS SOLUTION W/PHENOL ODOR

=================  Stability and Reactivity Data  =================

Stability Indicator/Materials to Avoid:YES
Hazardous Decomposition Products:BY THERMAL DECOMPOSITION/BURNING:
    NOXIOUS PRODUCTS; CO, CO2, NITROGEN OXIDES, SULFUR OXIDES

====================  Disposal Considerations  ====================

Waste Disposal Methods:DISPOSE OF IN ACCORDANCE W/LOCAL, STATE &
    FEDERAL REGULATIONS.

=======================  Other Information  =======================

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