BRISTOL MYERS SQUIBB -- TOBRAMYCIN SULFATE INJECTION 10MG/ML, 40 MG/ML -- -
===================== Product Identification =====================
Product ID:TOBRAMYCIN SULFATE INJECTION 10MG/ML, 40 MG/ML
MSDS Date:05/14/1992
FSC:NIIN:Submitter:F BT
Status Code:A
MSDS Number: CJKGF
=== Responsible Party ===
Company Name:BRISTOL MYERS SQUIBB
Box:191
City:NEW BRUNSWICK
State:NJ
ZIP:08903
Country:US
Info Phone Num:201-519-2885
Emergency Phone Num:908-519-2385
CAGE:IO660
=== Contractor Identification ===
Company Name:BRISTOL MYERS SQUIBB
Box:191
City:NEW BRUNSWICK
State:NJ
ZIP:08903
Country:US
Phone:201-519-2885
CAGE:IO660
============= Composition/Information on Ingredients =============
Ingred Name:TOBRAMYCIN SULFATE
CAS:49842-07-1
Minumum % Wt:1.
Maxumum % Wt:4.
Ingred Name:WATER
CAS:7732-18-5
RTECS #:ZC0110000
> Wt:1.
Ingred Name:PHENOL
< Wt:1.
Ingred Name:SODIUM METABISULFITE
CAS:7681-57-4
RTECS #:UX8225000
< Wt:1.
ACGIH TLV:5 MG/M3
Ingred Name:EDETATE DISODIUM
CAS:139-33-3
RTECS #:AH4375000
< Wt:1.
Ingred Name:SULFURIC ACID
CAS:7664-93-9
RTECS #:WS5600000
< Wt:1.
OSHA PEL:1 MG/M3
ACGIH TLV:1 MG/M3
ACGIH STEL:3 MG/M3
EPA Rpt Qty:1000 LBS
DOT Rpt Qty:1000 LBS
Ingred Name:SODIUM HYDROXIDE
CAS:1310-73-2
RTECS #:WB4900000
< Wt:1.
OSHA PEL:2 MG/M3
ACGIH STEL:C2 MG/M3
EPA Rpt Qty:1000 LBS
DOT Rpt Qty:1000 LBS
===================== Hazards Identification =====================
LD50 LC50 Mixture:ORAL LD50(MOUSE): >10,500 MG/KG
Routes of Entry: Inhalation:UNKNOWN Skin:YES Ingestion:YES
Health Hazards Acute and Chronic:TOBRAMYCIN SULFATE INJECTION CONTAINS
A POTENT AMINOGLYCOSIDE ANTIBIOTIC DRUG. IT IS INTENDED FOR
INTRAMUSCULAR/INTRAVENOUS INJECTION, UNDER THE CARE OF A PHYSICIAN.
ORALLY AMINOGLYCOSIDES ARE POORLY ABSORBED FROM THE GI TRACT.
ABSORPTION MAY OCCUR FROM LARGE DOSES TO WOUNDS/DENUDED SKIN/BURNS
MAY RESULT IN SYSTEMIC TOXICITY. ALLERGIC REACTION MAY OCCUR. EYES:
INFLAMMATION OF CONJUNCTIVA. MAY AFFE CT KIDNEYS, CAUSE
NEUROMUSCULAR DISORDERS. MAY AFFECT THE EARS (EIGHTH RANIAL NERVE)
& NERVOUS SYSTEM.
Effects of Overexposure:NAUSEA, VOMITING, DIARRHEA, ALTERED ABSORPTION
OF NUTRIENTS & ELECTROLYTE DISTURBANCES, RASH, URTICARIA,
STOMATITIS, PRURITUS, BURNING, FEVER, EOSINOPHILIA, HEARING LOSS,
NEUROMUSCULAR BLOCKADE, INFLA MMATION, REDNESS, ITCHING,
IRRITATION.
Medical Cond Aggravated by Exposure:IMPAIRED HEARING, KIDNEY DISORDERS,
NEUROMUSCULAR DISORDERS, ALLERGIES TO AMINOGLYCOSIDES.
======================= First Aid Measures =======================
First Aid:EYES: FLUSH W/LARGE AMOUNTS OF WATER FOR 15-20 MINS. SKIN:
WASH W/SOAP & WATER FOR 15-20 MINS. INHALATION: REMOVE TO FRESH
AIR; GIVE OXYGEN/CPR IF NECESSARY. OBTAIN MEDICAL ATTENTION IN ALL
CASES.
===================== Fire Fighting Measures =====================
Extinguishing Media:USE WATER
Fire Fighting Procedures:EVACUATE PERSONNEL TO SAFE AREA. USE A SELF
CONTAINED BREATHING APPARATUS & FULL PROTECTIVE CLOTHING. USE WATER
TO KEEP FIRE-EXPOSED COTNAINERS COOL. FIGHT FIRE FROM MAXIMUM
DISTANCE. DIVERT RUNOFF TO A SAFE AREA.
================== Accidental Release Measures ==================
Spill Release Procedures:WEARING SUITABLE PROTECTIVE CLOTHING, ABSORB
LIQUID ONTO ABSORBENT MATERIAL & PLACE INTO A CONTAINER FOR
DISPOSAL. THE AREA SHOULD BE VENTILATED & DECONTAMINATED AFTER
MATERIAL HAS BEEN PICKED UP.
====================== Handling and Storage ======================
Handling and Storage Precautions:STORE AT ROOM TEMPERATURE. PERSONNEL
WHO HANDLE THIS SOLUTION IN A MANUFACTURING FACILITY SHOULD WEAR
PROTECTIVE CLOTHING, IMPERMEABLE GLOVES, EYE PROTECTION & A GOWN.
PERSONNEL WHO HANDLE THIS SOLUTI ON IN A NON-MANUFACTURING
SETTING/CLINICAL FACILITY SHOULD WEAR IMPERMEABLE GLOVES & EYE
PROTECTION.
Other Precautions:PERSONS WHO ARE ALLERGIC TO TOBRAMYCIN SULFATE/OTHER
AMINOGLYCOSIDES SHOULD AVOID CONTACT W/THIS SUBSTANCE. THERAPEUTIC
AGENTS ARE INTENDED FOR USE UNDER DIRECTION OF A PHYSICIAN/UNDER
THE CONDITIONS OF USE DESCRIBED ON THE LABEL. PERSONNEL HANDLING
DRUG SUBSTANCES SHOULD AVOID CONTACT W/THESE SUBST ANCES.
============= Exposure Controls/Personal Protection =============
Respiratory Protection:REQUIRED
Ventilation:REQUIRED
Protective Gloves:IMPERMEABLE
Eye Protection:REQUIRED
Other Protective Equipment:GOWN, PROTECTIVE CLOTHING
Supplemental Safety and Health
================== Physical/Chemical Properties ==================
Boiling Pt:=100.C, 212.F
Melt/Freeze Pt:=0.C, 32.F
Vapor Pres:AS WATER
pH:5.7-5.8
Solubility in Water:MISCIBLE
Appearance and Odor:CLEAR, COLORLESS SOLUTION W/PHENOL ODOR
================= Stability and Reactivity Data =================
Stability Indicator/Materials to Avoid:YES
Hazardous Decomposition Products:BY THERMAL DECOMPOSITION/BURNING:
NOXIOUS PRODUCTS; CO, CO2, NITROGEN OXIDES, SULFUR OXIDES
==================== Disposal Considerations ====================
Waste Disposal Methods:DISPOSE OF IN ACCORDANCE W/LOCAL, STATE &
FEDERAL REGULATIONS.
======================= Other Information =======================
Disclaimer (provided with this information by the compiling agencies):
This information is formulated for use by elements of the Department
of Defense. The United States of America in no manner whatsoever,
expressly or implied, warrants this information to be accurate and
disclaims all liability for its use. Any person utilizing this
document should seek competent professional advice to verify and
assume responsibility for the suitability of this information to their
particular situation.