Rcra Waste Number U058
Material Safety Data Sheet
Cyclophosphamide monohydrate, 97%
ACC# 77640
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Section 1 - Chemical Product and Company Identification |
MSDS Name: Cyclophosphamide monohydrate, 97%
Catalog Numbers:
AC203960000, AC203960010, AC203960050
Synonyms:
N,N-Bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine
2-oxide monohydrate;
2-[Bis(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazophosphorine
2-oxide monohydrate; Cancer research tool.
Company Identification:
Acros Organics N.V.
One Reagent Lane
Fair Lawn, NJ 07410
For information in North America, call: 800-ACROS-01
For emergencies in the US, call CHEMTREC: 800-424-9300
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Section 2 - Composition, Information on Ingredients
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| CAS# |
Chemical Name |
Percent |
EINECS/ELINCS |
| 6055-19-2 |
Cyclophosphamide monohydrate |
97 | unlisted |
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Section 3 - Hazards Identification
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EMERGENCY OVERVIEW
Appearance: white to almost white solid.
Danger! Causes eye burns. May cause harm to the
unborn child. Harmful if swallowed. May be harmful if absorbed
through skin or if inhaled. May cause cancer in humans.
Target Organs: Eyes, bone marrow, reproductive
system, bladder.
Potential Health Effects
Eye:
Causes severe eye irritation and possible injury.
Skin:
May cause skin irritation. May be harmful if absorbed through the
skin.
Ingestion:
May cause irritation of the digestive tract. Poison by ingestion.
May cause nausea and vomiting.
Inhalation:
May cause respiratory tract irritation. May be harmful if inhaled.
May cause nausea and possible vomiting.
Chronic:
May cause cancer in humans. May cause reproductive and fetal
effects.
In case of a therapeutical use of the product, typical side effects
are: myelosuppression (suppression of bone marrow activity resulting
in reduction in the number of platelets, red cells, and white
cells), gastrointestinal complaints, cystitis (inflammation of the
urinary bladder), hair loss, disorders of spermatogenesis or
ovulation.
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Section 4 - First Aid Measures
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Eyes:
Immediately flush eyes with plenty of water for at least 15 minutes,
occasionally lifting the upper and lower eyelids. Get medical aid imme
diately.
Skin:
Get medical aid immediately. Immediately flush skin with plenty of
water for at least 15 minutes while removing contaminated clothing
and shoes.
Ingestion:
Get medical aid immediately. Wash mouth out with water.
Inhalation:
Get medical aid immediately. Remove from exposure and move to fresh
air immediately. If not breathing, give artificial respiration. If
breathing is difficult, give oxygen.
Notes to Physician:
Treat symptomatically and supportively.
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Section 5 - Fire Fighting Measures
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General Information:
As in any fire, wear a self-contained breathing apparatus in
pressure-demand, MSHA/NIOSH (approved or equivalent), and full
protective gear. Will burn if involved in a fire. This material in
sufficient quantity and reduced particle size is capable of creating
a dust explosion.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or chemical foam.
Flash Point: > 112 deg C (> 233.60 deg F)
Autoignition Temperature: Not available.
Explosion Limits, Lower:Not available.
Upper: Not available.
NFPA Rating:
(estimated) Health: 3; Flammability: 1; Instability: 1
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Section 6 - Accidental Release Measures
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General Information: Use proper personal protective equipment as indicated
in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal
container. Avoid generating dusty conditions. Provide ventilation.
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Section 7 - Handling and Storage
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Handling:
Wash thoroughly after handling. Remove contaminated clothing and
wash before reuse. Minimize dust generation and accumulation. Do not
get in eyes, on skin, or on clothing. Take precautionary measures
against static discharges. Do not breathe dust. Use only with
adequate ventilation.
Storage:
Store in a cool, dry place. Store in a tightly closed container.
Keep under an argon blanket.
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Section 8 - Exposure Controls, Personal Protection
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Engineering Controls:
Facilities storing or utilizing this material should be equipped
with an eyewash facility and a safety shower. Use adequate
ventilation to keep airborne concentrations low.
Exposure Limits
| Chemical Name |
ACGIH |
NIOSH |
OSHA - Final PELs |
| Cyclophosphamide monohydrate
|
none listed
|
none listed
|
none listed
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| Cyclophosphamide (anhydrous form)
|
none listed
|
none listed
|
none listed
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OSHA Vacated PELs:
Cyclophosphamide monohydrate:
No OSHA Vacated PELs are listed for this chemical.
Cyclophosphamide (anhydrous form):
No OSHA Vacated PELs are listed for this chemical.
Personal Protective Equipment
Eyes:
Wear appropriate protective eyeglasses or chemical
safety goggles as described by OSHA's eye and face
protection regulations in 29 CFR 1910.133 or European
Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin
exposure.
Clothing:
Wear appropriate protective clothing to prevent skin
exposure.
Respirators:
Follow the OSHA respirator regulations found in 29
CFR 1910.134 or European Standard EN 149. Use a
NIOSH/MSHA or European Standard EN 149 approved
respirator if exposure limits are exceeded or if
irritation or other symptoms are experienced.
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Section 9 - Physical and Chemical Properties
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Physical State: Solid
Appearance: white to almost white
Odor: odorless
pH: 4 - 6 (2% aq soln)
Vapor Pressure: 0.000033 HPa @ 20 deg C
Vapor Density: Not available.
Evaporation Rate:Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point:49 - 53 deg C
Decomposition Temperature:90 deg C
Solubility: 40 g/l water
Specific Gravity/Density:Not available.
Molecular Formula:C7H15Cl2N2O2P.H2O
Molecular Weight:279.09
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Section 10 - Stability and Reactivity
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Chemical Stability:
Stable at room temperature in closed containers under normal storage
and handling conditions. Exothermic decomposition at 90�C (Method VDI
2263).
Conditions to Avoid:
Dust generation, excess heat.
Incompatibilities with Other Materials:
Strong oxidizing agents, acids, bases.
Hazardous Decomposition Products:
Hydrogen chloride, nitrogen oxides, phosphine, carbon monoxide,
oxides of phosphorus, carbon dioxide.
Hazardous Polymerization: Has not been reported.
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Section 11 - Toxicological Information
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RTECS#:
CAS# 6055-19-2:
RP6157750
CAS# 50-18-0:
RP5950000
LD50/LC50:
CAS# 6055-19-2:
Oral, mouse: LD50
= 350 mg/kg;
Oral, rat: LD50 = 94
mg/kg;
.
CAS# 50-18-0:
Oral, mouse:
LD50 = 137 mg/kg;
Oral, rat: LD50 =
100 mg/kg;
.
Primary irritative effect to the eyes: Corrosive, rabbit, OECD 405.
Carcinogenicity:
CAS# 6055-19-2:
- ACGIH:
Not listed.
- California:
carcinogen, initial date 2/27/87
- NTP:
Not listed.
- IARC:
Group 1 carcinogen
CAS# 50-18-0:
- ACGIH:
Not listed.
- California:
carcinogen, initial date 2/27/87
- NTP:
Known carcinogen
- IARC:
Group 1 carcinogen
Epidemiology:
No data available.
Teratogenicity:
No data available.
Reproductive Effects:
No data available.
Mutagenicity:
No data available.
Neurotoxicity:
No data available.
Other Studies:
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Section 12 - Ecological Information
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Ecotoxicity:
No data available.
No information available.
Environmental:
Degradation (28 days) <1%, not easily biodegradable, OECD 301 E.
Physical:
No information available.
Other:
No information available.
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Section 13 - Disposal Considerations
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Chemical waste generators must determine whether a discarded chemical is classified
as a hazardous waste.
US EPA guidelines for the classification determination are listed in 40 CFR Parts 261.3.
Additionally, waste generators must consult state and local hazardous waste regulations to
ensure complete and accurate classification.
RCRA P-Series: None listed.
RCRA U-Series:
CAS# 50-18-0: waste
number U058.
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Section 14 - Transport Information
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| |
US DOT |
Canada TDG |
| Shipping Name: |
DOT regulated - small quantity provisions apply (see 49CFR173.4) |
TOXIC SOLID, ORGANIC, N.O.S. |
| Hazard Class: |
|
6.1 |
| UN Number: |
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UN2811 |
| Packing Group: |
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III |
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Section 15 - Regulatory Information
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US FEDERAL
TSCA
CAS# 6055-19-2 is not listed on the TSCA inventory.
It is for research and development use only.
CAS# 50-18-0 is not listed on the TSCA inventory.
It is for research and development use only.
Health & Safety Reporting List
None of the chemicals are on the Health & Safety Reporting List.
Chemical Test Rules
None of the chemicals in this product are under a Chemical Test Rule.
Section 12b
None of the chemicals are listed under TSCA Section 12b.
TSCA Significant New Use Rule
None of the chemicals in this material have a SNUR under TSCA.
CERCLA Hazardous Substances and corresponding RQs
CAS# 50-18-0: 10 lb final RQ; 4.54 kg final RQ
SARA Section 302 Extremely Hazardous Substances
None of the chemicals in this product have a TPQ.
SARA Codes
CAS # 6055-19-2: immediate, delayed.
Section 313
No chemicals are reportable under Section 313.
Clean Air Act:
This material does not contain any hazardous air pollutants.
This material does not contain any Class 1 Ozone depletors.
This material does not contain any Class 2 Ozone depletors.
Clean Water Act:
None of the chemicals in this product
are listed as Hazardous Substances under the CWA.
None of the chemicals in this
product are listed as Priority Pollutants under the CWA.
None of the chemicals in this
product are listed as Toxic Pollutants under the CWA.
OSHA:
None of the chemicals in this product
are considered highly hazardous by OSHA.
STATE
CAS# 6055-19-2 can be found on the
following state right to know lists: California.
CAS# 50-18-0 can be found on the
following state right to know lists: California, New Jersey,
Pennsylvania, Minnesota, Massachusetts.
California Prop 65
The following statement(s) is(are) made in order to comply with
the California Safe Drinking Water Act:
WARNING: This product contains Cyclophosphamide monohydrate, a
chemical known to the state of California to cause cancer.
WARNING: This product contains Cyclophosphamide monohydrate, a
chemical known to the state of California to cause male reproductive
toxicity.
WARNING: This product contains Cyclophosphamide (anhydrous fo, a
chemical known to the state of California to cause cancer.
WARNING: This product contains Cyclophosphamide (anhydrous fo, a
chemical known to the state of California to cause male reproductive
toxicity.
California No Significant Risk Level:
CAS# 6055-19-2: 1 �g/day NSRL
CAS# 50-18-0: 1 �g/day NSRL
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols:
T
Risk Phrases:
R 25 Toxic if swallowed.
R 41 Risk of serious damage to eyes.
R 45 May cause cancer.
R 46 May cause heritable genetic damage.
R 48/23/24/25 Toxic : danger of serious damage to health by
prolonged exposure through inhalation, contact with skin and if
swallowed.
R 61 May cause harm to the unborn child.
Safety Phrases:
S 15 Keep away from heat.
S 26 In case of contact with eyes, rinse immediately with plenty of
water and seek medical advice.
S 45 In case of accident or if you feel unwell, seek medical advice
immediately (show the label where possible).
S 53 Avoid exposure - obtain special instructions before use.
WGK (Water Danger/Protection)
CAS# 6055-19-2: 3
CAS# 50-18-0: No information available.
Canada - DSL/NDSL
CAS# 50-18-0 is listed on Canada's DSL List.
Canada - WHMIS
This product has a WHMIS classification of D2A, D1B.
This product has been classified in accordance with the hazard
criteria of the Controlled Products Regulations and the MSDS
contains all of the information required by those regulations.
Canadian Ingredient Disclosure List
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Section 16 - Additional Information
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MSDS Creation Date: 1/18/2000
Revision #4 Date: 10/03/2005
The information above is believed to be accurate and represents the best
information currently available to us. However, we make no warranty of
merchantability or any other warranty, express or implied, with respect to
such information, and we assume no liability resulting from its use. Users
should make their own investigations to determine the suitability of the
information for their particular purposes. In no event shall Fisher be liable
for any claims, losses, or damages of any third party or for lost profits
or any special, indirect, incidental, consequential or exemplary
damages, howsoever arising, even if Fisher has been advised of
the possibility of such damages.