Prostaglandin I2

DU PONT E I DE NEMOURS AND CO INC -- BREVIBLOC -- 6505-01-304-4971
=====================  Product Identification  =====================

Product ID:BREVIBLOC
MSDS Date:01/07/1987
FSC:6505
NIIN:01-304-4971
MSDS Number: BRFWG
=== Responsible Party ===
Company Name:DU PONT E I DE NEMOURS AND CO INC
Address:1007 MARKET STREET
City:WILMINGTON
State:DE
ZIP:19898
Country:US
Info Phone Num:302-992-4132
Emergency Phone Num:800-441-7515(TRANS)800-441-3637MED
CAGE:0BA38
=== Contractor Identification ===
Company Name:DU PONT E I DE NEMOURS AND CO INC CHEM
Address:DELLE DONNE CORPORATE CTR
City:WILMINGTON
State:DE
ZIP:19880-0800
Country:US
Phone:800-441-7515
CAGE:0BA38
Company Name:DU PONT MERCK PHARMACEUTICAL CO, THE
Address:BARLEY MILL PLAZA
Box:80026
City:WILMINGTON
State:DE
ZIP:19880-0026
Country:US
Phone:800-441-9861
CAGE:04490

=============  Composition/Information on Ingredients  =============

Ingred Name:ESMOLOL HYDROCHLORIDE
CAS:81161-17-3
RTECS #:DA8346000
Fraction by Wt: 1%
Other REC Limits:NONE SPECIFIED

Ingred Name:INERT INGREDIENTS
Fraction by Wt: 99%
Other REC Limits:NONE RECOMMENDED

=====================  Hazards Identification  =====================

LD50 LC50 Mixture:LD50 (ORAL RAT) IS  71 MG/KG
Routes of Entry: Inhalation:YES  Skin:YES  Ingestion:YES
Reports of Carcinogenicity:NTP:NO    IARC:NO	OSHA:NO
Health Hazards Acute and Chronic:BREVIBLOC INJECTION IS FORMULATED FOR
    HUMAN THEREPUTIC USE AND CONTAINS 1% ESMOLOL HYDROCHLORIDE BY
    VOLUME. NORMAL HANDLING OF THIS PRODUCT IS NOT CONSID4ERED
    HAZARDOUS. THE FOLLOWING INFORMATION IS P ROVIDED FOR THOSE
    CIRCUMSTANCES WHERE HANDLING OF THIS PRODUCTRESULTS IN SIGNIFICANT
    POTENTIAL FOR EXPOSURE.
Explanation of Carcinogenicity:THE PRODUCT CONTAINS NO INGREDIENT AT
    0.1% OR GREATER THAT IS LISTED BY IARC, NTP OR OSHA AS A
    CARCINOGEN.
Effects of Overexposure:EXPOSURE MAY CAUSE ITCHING AND BURNING OF THE
    EYES. NO INFORMATION AVAILABLE CONCERNING EXPOSURE VIA SKIN CONTACT
    OR INHALATION. PATIENTS IN CLINICAL TRIALS HAVE EXPERIENCEC
    HYPOTENSION. ABOUT 12% HAV E HAD DIAPHORESIS AND DIZZINESS..
Medical Cond Aggravated by Exposure:NOT GIVEN.

=======================  First Aid Measures  =======================

First Aid:EYE:FLUSH W/WATER 15 MIN, HOLD LIDS OPEN. SKIN:REMOVE
    CONTAMINATED CLOTHING AND LAUNDER BEFORE REUSE. WASH WITH SOAP &
    WATER. INHALED:REMOVE TO FRESH AIR. RESTORE/AID BREATHING AS
    NEEDED. INGESTED:IMM EDIATELY GIVE 2 LARGE GLASSES OF MILK ORWATER
    AND INDUCE VOMITING. (NOTHING BY MOUTH IF UNCONSCIOUS.)  GET
    IMMEDIATE MEDICAL CARE. IF ANY IRRITATION PERSISTS OR IS SEVERE,
    SEE A DOCTOR.

=====================  Fire Fighting Measures  =====================

Flash Point Method:CC
Flash Point:89.6F,32.0C
Autoignition Temp:Autoignition Temp Text:743F
Extinguishing Media:CARBON DIOXIDE, FOAM, OR DRY CHEMICAL.
Fire Fighting Procedures:EVACUATE PERSONNEL TO A SAFE AREA. KEEP
    PERSONNEL REMOVED AND UPWIND OF FIRE. WEAR SELF-CONTAINED BREATHING
    APPAAAARATUS. WEAR FULL PROTECTIVE EQUIPMENT.
Unusual Fire/Explosion Hazard:NO INFORMATION GIVEN ON MSDS BY MFR.

==================  Accidental Release Measures  ==================

Spill Release Procedures:REVIEW "FIRE & EXPLOSION HAZARDS" AND "SAFETY
    PRECAUTIONS" BEFORE PROCEDING WITH CLEAN UP. USE APPROPRIATE
    PERSONAL PROTECTIVE EQUIPMENT DURING CLEAN UP. NO SPECIAL PROCEDURE
    REQUIRED FOR SMALL CLEAN- UP.
Neutralizing Agent:NO INFORMATION GIVEN ON MSDS BY MFR.

======================	Handling and Storage  ======================

Handling and Storage Precautions:STORE AT ROOM TEMPERATURE(59-86F).
    FREEZING DOES NOT ADVERSELY AFFECT THE PRODUCT BBUT EXPOSURE TO
    ELEVATED TEMPERATURES SHOULD BE AVOIDED.
Other Precautions:KEEP	CONTAINER IN A DARK PLACE. KEEP CONTAINER
    TIGHTLY CLOSED. CLOSE CONTAAINER AFTER EACH USE. DO NOT CONSUME
    FOOD, DRINK, OR TOBACCO IN AREAS WHERE THEY MAY BE CONTAMINATED
    WITH THIS MATERIAL.

=============  Exposure Controls/Personal Protection  =============

Respiratory Protection:THIS MATERIAL HAS NO ESTABLISHED EXPOSURE
    LIMITS. USE A NIOSH/MSHA APPROVED AIR PURIFYING RESPIRATOR OR AIR
    SUPPLIED RESPIRATOR WHEN A RESPIRATOR IS JUDGED TO BE APPROPRIATE
    TO PREVENT INHALATION OF V APOR OR MIST.
Ventilation:NO INFORMATION GIVEN ON MSDS BY MFR.  HMIS: SUPPLU
    SUFFICIENT VENTILATION TO PRECLUDE THE USE OF RESPIRATORS.
Protective Gloves:NEOPRENE OR TYVEK
Eye Protection:SAFETY GLASSES & FULL FACE PROTECTION
Other Protective Equipment:WEAR IMPERVIOUS COLOTHING MADE OF NEOPRENE 
    OR TYVEK, SUCH AS APRON, BOOTS, JUMP SUIT AS APPROPRIATE.
Work Hygienic Practices:MFR: ?	HMIS:USE GOOD CHEMICAL HYGIENE
    PRACTICE. AVOID UNNECESSARY CONTACT. WASH THOROUGHLY BEFORE EATING
    OR DRINKING.
Supplemental Safety and Health
KEY2:KT

==================  Physical/Chemical Properties  ==================

HCC:F3
NRC/State Lic Num:NONE
Spec Gravity:1.026
pH:3.5-6
Appearance and Odor:CLEAR, COLORLESS TO SLIGHTLY YELLOW SOLUTION WITH A
    DISTINCTIVE ALCOHOL ODOR

=================  Stability and Reactivity Data  =================

Stability Indicator/Materials to Avoid:YES
NONE REASONABLY FORSEEABLE.
Stability Condition to Avoid:STABLE AT NORMAL TEMPERATURE AND STORAGE
    CONDITIONSEGRADATION MAY RESULT.
Hazardous Decomposition Products:DECOMPOSES WITH HEAT
Conditions to Avoid Polymerization:WILL NOT OCCUR

====================  Disposal Considerations  ====================

Waste Disposal Methods:TREATMENT, STORAGE, TRANSPORTATION AND DISPOSAL
    MUST BW I/A/W FEDERAL, STATE/PROVINCIAL & LOCAL REGULATIONS.

 Disclaimer (provided with this information by the compiling agencies):
 This information is formulated for use by elements of the Department
 of Defense.  The United States of America in no manner whatsoever,
 expressly or implied, warrants this information to be accurate and
 disclaims all liability for its use.  Any person utilizing this
 document should seek competent professional advice to verify and
 assume responsibility for the suitability of this information to their
 particular situation.