FUJISAWA USA INC -- PROGRAF, FK506 -- 6505-00N064555
===================== Product Identification =====================
Product ID:PROGRAF, FK506
MSDS Date:01/01/1994
FSC:6505
NIIN:00N064555
MSDS Number: BZKJS
=== Responsible Party ===
Company Name:FUJISAWA USA INC
Address:3 PARKWAY NORTH
City:DEERFIELD
State:IL
ZIP:60015-2548
Country:US
Info Phone Num:708-317-8200
Emergency Phone Num:708-317-8202; 800-727-7003
Preparer's Name:CHRISTINA J BARRINGTON
CAGE:24832
=== Contractor Identification ===
Company Name:FUJISAWA USA INC (LYPHOMED INC)
Address:3 PARKWAY NORTH
City:DEERFIELD
State:IL
ZIP:60015-2548
Country:US
Phone:800-727-7003/708-317-8800
CAGE:24832
Company Name:FUJISAWA USA, INC.
Address:3 PARKWAY NORTH
Box:City:DEERFIELD
State:IL
ZIP:60015-2548
Country:US
Phone:708-317-0800 OR 800-888-7704
CAGE:0K706
============= Composition/Information on Ingredients =============
Ingred Name:ETHYL ALCOHOL; (DEHYDRATE ALCOHOL)
CAS:64-17-5
RTECS #:KQ6300000
OSHA PEL:1000 PPM
ACGIH TLV:1000 PPM; 9495
Ingred Name:15,19-EPOXY-3H-PYRIDO(2,1-C)(1,4)OXAAZACYCLOTRI
COSINE-1,7,20,21(4H,23H)-TETRONE,5,6,8,11,12,13,14,15,16,17,18,19(I
NG 3)
CAS:104987-11-3
RTECS #:KD4200000
OSHA PEL:N/K
ACGIH TLV:N/K
Ingred Name:ING 2:24,25,26,26A-HEXADECAHYDRO-5,19-DIHYROXY-3-
(2-(4-HYDROXY-3-METHOXYCYCLOHEXYL)-14,16-DIMETHOXY-4,10,12,18-(ING
4)
RTECS #:9999999ZZ
OSHA PEL:N/K
ACGIH TLV:N/K
Ingred Name:ING 3:TETRAMETHYL-8-(2-PROPENYL)-,(3S-(3R*(E(1S*,
3S*,4S*)),4S*,5R*,8S*,9E,12R*,14R*,15S*,16R*,18S*,19S*,(ING 5)
RTECS #:9999999ZZ
OSHA PEL:N/K
ACGIH TLV:N/K
Ingred Name:ING 4:26AR*))-; (MACROLIDE LACTONE).
RTECS #:9999999ZZ
OSHA PEL:N/K
ACGIH TLV:N/K
Ingred Name:WATER; (WATER FOR INJECTION)
CAS:7732-18-5
RTECS #:ZC0110000
OSHA PEL:N/K
ACGIH TLV:N/K
===================== Hazards Identification =====================
LD50 LC50 Mixture:NONE SPECIFIED BY MANUFACTURER.
Routes of Entry: Inhalation:YES Skin:YES Ingestion:YES
Reports of Carcinogenicity:NTP:NO IARC:NO OSHA:NO
Health Hazards Acute and Chronic:THIS PRODUCT IS INTENDED FOR
THERAPEUTIC USE ONLY WHEN PRESCRIBED BY A PHYSICIAN. POTENTIAL
ADVERSE REACTIONS FROM PRESCRIBED DOSES AND OVERDOSES ARE DESCRIBED
IN THE PACKAGE INSERT. OCCUPATIONAL EXPO SURE HAS NOT BEEN FULLY
INVESTIGATED. IMMEDIATE EFFECTS:EYE, SKIN & RESPIRATORY IRRITATION,
HEADACHE,(EFTS OF OVEREXP)
Explanation of Carcinogenicity:NOT RELEVANT.
Effects of Overexposure:HLTH HAZ:NAUSEA, AND VOMITING, HAVE BEEN
EXPERIENCED WITH PATIENT ADMINISTRATION.
Medical Cond Aggravated by Exposure:PRE-EXISTING SKIN AND RESPIRATORY
CONDITIONS.
======================= First Aid Measures =======================
First Aid:INHAL: MOVE PERSON TO FRESH AIR IMMED. GIVE ARTIFICIAL
RESPIRATION & CARDIOPULMONARY RESUSCITATION (CPR) IF REQUIRED. SEEK
MED ATTN. INGEST: FLUSH MOUTH OUT W/H*2O IMMED. SEEK MED ATTN.
SKIN: REMOVE C ONTAMINATED CLOTHING IMMED. FLUSH AREA WITH H*2O FOR
AT LEAST 15 MIN. SEEK MED ATTN. EYE: IMMED FLUSH WITH H*2O FOR AT
LEAST 15 MIN. SEEK MED ATTN. FOR ADVERSE DRUG REACTION INFO CALL
(708) 317-5937.
===================== Fire Fighting Measures =====================
Flash Point:>200F,>93C
Extinguishing Media:WATER SPRAY, DRY CHEMICAL, CARBON DIOXIDE OR FOAM
AS APPROPRIATE.
Fire Fighting Procedures:USE NIOSH/MSHA APPROVED SCBA & FULL PROTECTIVE
EQUIPMENT .
Unusual Fire/Explosion Hazard:WHEN HEATED TO DECOMPOSITION IT EMITS
TOXIC FUMES.
================== Accidental Release Measures ==================
Spill Release Procedures:CLEAN-UP: WEAR RECOMMENDED PERSONAL PROTECTIVE
EQUIPMENT. USE ABSORBENT TOWELS OR BOOMS TO CLEAN-UP SPILL. WIPE
SURFACES CLEAN AND WASH WITH SOAP AND WATER.
Neutralizing Agent:NONE SPECIFIED BY MANUFACTURER.
====================== Handling and Storage ======================
Handling and Storage Precautions:WHEN HANDLING PHARMACEUTICAL PRODUCTS,
AVOID ALL CONTACT AND INHALATION OF DUST, FUMES, MIST, AND/OR
VAPORS ASSOCIATED WITH THE PRODUCT.
Other Precautions:NONE SPECIFIED BY MANUFACTURER.
============= Exposure Controls/Personal Protection =============
Respiratory Protection:WITH SATISFACTORY VENTILATION, RESPIRATORY
PROTECTION NOT USUALLY REQUIRED. NIOSH/MSHA APPROVED RESPIRATOR
APPROPRIATE FOR EXPOSURE OF CONCERN .
Ventilation:GENERAL ROOM VENTILATION IS USUALLY SATISFACTORY, USE LOCAL
EXHAUST VENTILATION WHEN NECESSARY.
Protective Gloves:DISPOSABLE LATEX GLOVES.
Eye Protection:ANSI APPROVED CHEM WORKERS GOGGS .
Other Protective Equipment:ANSI APPRVD EMER EYE WASH & DELUGE SHOWER .
DISPOSABLE GARMENTS IF DIRECT SKIN CONTACT IS ANTICIPATED.
Work Hygienic Practices:NONE SPECIFIED BY MANUFACTURER.
Supplemental Safety and Health
NONE SPECIFIED BY MANUFACTURER.
================== Physical/Chemical Properties ==================
Melt/Freeze Pt:M.P/F.P Text:259F,126C
Solubility in Water:ORGANIC SOLVENT
Appearance and Odor:CLEAR, STERILE SOLUTION.
================= Stability and Reactivity Data =================
Stability Indicator/Materials to Avoid:YES
NONE SPECIFIED BY MANUFACTURER.
Stability Condition to Avoid:PROTECT FROM FREEZING.
Hazardous Decomposition Products:SMOKE, AND NO*X FUMES.
==================== Disposal Considerations ====================
Waste Disposal Methods:DISPOSE OF IN ACCORDANCE WITH FEDERAL, STATE AND
LOCAL REGULATIONS.
Disclaimer (provided with this information by the compiling agencies):
This information is formulated for use by elements of the Department
of Defense. The United States of America in no manner whatsoever,
expressly or implied, warrants this information to be accurate and
disclaims all liability for its use. Any person utilizing this
document should seek competent professional advice to verify and
assume responsibility for the suitability of this information to their
particular situation.