Procarbazina [Inn-Spanish]

HOFFMANN-LA ROCHE INC -- PROCARBAZINE HYDROCHLORIDE -- 6505-00-175-6061
=====================  Product Identification  =====================

Product ID:PROCARBAZINE HYDROCHLORIDE
MSDS Date:07/14/1989
FSC:6505
NIIN:00-175-6061
MSDS Number: BNBQR
=== Responsible Party ===
Company Name:HOFFMANN-LA ROCHE INC
Address:340 KINGSLAND ST
City:NUTLEY
State:NJ
ZIP:07110-1141
Country:US
Info Phone Num:201-235-3729 OR 201-235-2377
Emergency Phone Num:201-235-3729
CAGE:1V283
=== Contractor Identification ===
Company Name:HOFFMAN-LA ROCHE INC
Address:340 KINGSLAND ST
City:NUTLEY
State:NJ
ZIP:07110-1141
Country:US
Phone:201-235-2323
CAGE:04493
Company Name:HOFFMANN-LA ROCHE INC.
Address:200 ROCHE DRIVE
City:BELVIDERE
State:NJ
ZIP:07823-1112
Phone:(800) 526-0625
CAGE:1V283

=============  Composition/Information on Ingredients  =============

Ingred Name:P-TOLUAMIDE, N-ISOPROPYL-A-(2-METHYLHYDRAZINO)-,
    MONOHYDROCHLORIDE; (BENZAMIDE) (PROCARBAZINE HYDROCHLORIDE
    CHLORIDE)
CAS:366-70-1
RTECS #:XS4725000
Fraction by Wt: 100%

Ingred Name:SUPP DATA:WOMEN SHOULD EXERCISE CAUTION REGARDING POTNTL
    EXPOS. ALSO ADVISABLE FOR NURSING MOTHERS TO EXERCISE CAUTION.
RTECS #:9999999ZZ

Ingred Name:SPILL PROC:COVER & MOVE CNTNR TO SAFE HOLDING AREA.CLEAN
    SPILL AREA THORO. DECONTAM/DISPOSE OF ALL PROTECTIVE EQUIPMENT.
RTECS #:9999999ZZ

Ingred Name:WASTE DISP METH:REGULATORY AUTHOR BEFORE DETERMINING FINAL
    METHOD OF DISP. DISP OF I/A/W FED, STATE & LOCAL REGS .
RTECS #:9999999ZZ

Ingred Name:OTHER PREC:CLOSED CNTNRS UNDER NITROGEN/IN AMBER BOTTLES.
    AVOID ALL PERS CNTCT. DO NOT GET IN EYES, ON SKIN OR (ING 6)
RTECS #:9999999ZZ

Ingred Name:ING 5:CLTHG. DO NOT BREATHE DUST. AVOID CREATING DUST WHEN
    HNDLG. USE ONLY W/ADEQ VENT. KEEP CNTNR TIGHTLY CLOSED(ING 7)
RTECS #:9999999ZZ

Ingred Name:ING 6:WHEN NOT IN USE. WHEN HNDLG, WEAR PROPER RESP & OTHER
    PERS PROTECTIVE EQUIPMENT. FULL BODY SUIT RECOMMENDED.
RTECS #:9999999ZZ

Ingred Name:PROT GLOVES:NOT USE POLYVINYL CHLORIDE.INSPECT FREQUENTLY &
    DISCARD WHEN THEY SHOW CUTS, TEARS, PINHOLES/SIGNS OF WEAR).
RTECS #:9999999ZZ

Ingred Name:OTHER PROT EQUIP:FULLY FASTENED DISP LAB COAT/DISP
    JUMPSUIT. LAB WORK SURFS SHOULD BE COVERED W/STAINLESS STEEL,(ING
    10)
RTECS #:9999999ZZ

Ingred Name:ING 9:PLASTIC TRAYS, DRY ABSORB PLASTIC BACKED PAPER/OTHER
    IMPERVIOUS MATL. DECONTAM WORK SURFS & DISPOSE OF (ING 11)
RTECS #:9999999ZZ

Ingred Name:ING 10:PROTECTIVE CLOTHING OR SURFACE COVERING PROPERLY.
    EMERGENCY EYEWASH, DELUGE SHOWER .
RTECS #:9999999ZZ

Ingred Name:PH: 3-4 (5% IN H*2O)
RTECS #:9999999ZZ

=====================  Hazards Identification  =====================

LD50 LC50 Mixture:LD50:(ORAL,RAT)785 MG/KG.
Routes of Entry: Inhalation:YES  Skin:NO  Ingestion:YES
Reports of Carcinogenicity:NTP:YES    IARC:YES	  OSHA:NO
Health Hazards Acute and Chronic:ACUTE/CHRONIC:BASED ON SYMPS ASSOC
    W/THERAPEUTIC USE OF MATL, MOST COMMON EFTS ARE:BLOOD CHANGES,
    I.E.,DECREASE IN NUMBER OF WHITE CELLS & PLATELETS; GI EFTS,
    E.G.,NAUSEA & VOMIT. OTHER REPORTED EFTS  INCLUDE:CENTRAL &
    PERIPHERAL NERVOUS SYS EFTS, E.G.,NUMBNESS & TINGLING SENSATIONS,
    DIZZ; PSYCHO-MOTOR (EFTS OF OVEREXP)
Explanation of Carcinogenicity:PROCARBAZINE HYDROCHLORIDE: GROUP 2
    (NTP), GROUP 2A (IARC).
Effects of Overexposure:HLTH HAZ:EFTS, E.G.,WEAKNESS & FATIGUE, DROWS,
    HDCH; SKIN RXN, E.G.,DERM & ITCHING; MUSC EFTS, E.G.,JOINT PAIN;
    RESP EFTS, E.G.,FLUID BUILD-UP IN PERITONEAL & PLEURAL CAVITY,
    EDEMA, DFCLTY IN BRTHG, C OUGH; TEMP ABNORM, E.G.,CHILLS, FEVER;
    BLEEDING TENDENCY, E.G.,INTRADERMAL HEMMORHAGE, NOSEBLEEDS. MAY
    CAUSE (SUPP DATA)
Medical Cond Aggravated by Exposure:PROCARBAZINE HYDROCHLORIDE ALLERGY
    HISTORY, IMPAIRED LIVER/KIDNEY FUNCTION; BLOOD DISTURB; BASED ON
    THERAPEUTIC USE OF MATL, ADVERSE RXN MAY OCCUR W/ALCOHOLIC
    BEVERAGES, E.G.,INTENSE WARMTH(SUPP DATA)

=======================  First Aid Measures  =======================

First Aid:EYE:FLUSH W/PLENTY OF WATER. IF IRRIT, CALL MD. SKIN:FLUSH
    W/PLENTY OF WATER & WASH CNTCT AREA W/SOAP & WATER. IF IRRIT, CALL
    MD. REMOVE CONTAMD CLTHG & SHOES & WASH BEFORE REUSE. INHAL:REMOVE
    TO FRES H AIR. IF DISCOMFORT OCCURS/PERSISTS, CALL MD. INGEST:CALL
    MD IMMEDIATELY .

=====================  Fire Fighting Measures  =====================

Extinguishing Media:AS APPROPRIATE FOR FIRE IN SURROUNDING MATERIALS.
Fire Fighting Procedures:WEAR NIOSH/MSHA APPROVED SCBA AND FULL
    PROTECTIVE EQUIPMENT . USE WATER TO KEEP FIRE-EXPOSED CONTAINERS
    COOL.
Unusual Fire/Explosion Hazard:UNKNOWN.

==================  Accidental Release Measures  ==================

Spill Release Procedures:EVACUATE AREA & DO NOT RETURN UNLESS PROT BY
    NIOSH/MSHA APPRVD SCBA & PERS PROT CLTHG. SHUT OFF SOURCE OF
    LEAK/SPILL IF SAFE TO DO SO. AVOID SKIN CNTCT/BRTHG DUSTS.
    SCOOP/SHOVEL SPILLED MATL INTO SUIT ABLE LABELED OPEN-HEAD DRUM.
    SECURE DRUM (ING 3)
Neutralizing Agent:NONE SPECIFIED BY MANUFACTURER.

======================	Handling and Storage  ======================

Handling and Storage Precautions:UNDERGOES OXIDATION BY ATMOSPHERIC O*2
    IN PRESENCE OF MOISTURE/IN AQ SOLN (AUTOXIDATION MAY BE CATALYZED
    BY METAL IONS, E.G.,MANGANESE & COPPER).
Other Precautions:DEGRADES RAPIDLY IN ALCOHOLIC MEDIA. BEST STABILITY
    IS IN AQUEOUS ACID. VERY SENSITIVE TO ULTRAVIOLET LIGHT. AVOID
    CNTCT W/AIR & LIGHT. ALL OPERATIONS MUST BE CARRIED OUT UNDER
    NITROGEN. STORE AT ROOM  TEMP IN DRY PLACE IN TIGHTLY (ING 5)

=============  Exposure Controls/Personal Protection  =============

Respiratory Protection:USE NIOSH/MSHA APPROVED SUPPLIED-AIR
    POSITIVE-PRESSURE FULL FACEPIECE RESPIRATOR OR SUPPLIED-AIR HOOD.
Ventilation:LOCAL EXHAUST:SPECIFIC VENTILATION REQUIRED.
    MECHANICAL:REQUIRED. OTHER:LABORATORY-TYPE HOOD.
Protective Gloves:DISPOSABLE SURGICAL LATEX (DO (ING 8)
Eye Protection:CHEM WORK GOG & FULL LENGTH FSHLD.
Other Protective Equipment:PROD OPS:WEAR FULL BODY SUIT INCLDG HEAD &
    FOOT COVERING W/SLEEVES TUCKED UNDER GLOVES & TAPED. FOR LAB
    OPS:WEAR (ING 9)
Work Hygienic Practices:DECONTAM WORK SURFS & DISPOSE OF PROT
    CLTHG/SURF COVERING PROPERLY. WASH THOROUGHLY OR SHOWER AFTER
    HANDLING.
Supplemental Safety and Health
SOL IN H*2O:(200 MG/ML) BUT DECOMPOSES. EFTS OF OVEREXP:CANCER &
    TERATOGENIC EFTS. MAY AFFECT MALE FERTILITY. MED CDNTNS: &
    REDDENING OF FACE, AS WELL AS W/CERTAIN FOODS & CERTAIN OTHER
    DRUGS. NOTE:SI NCE MATL MAY AFFECT MALE REPRO CAPABILITY &
    DEVELOPING FETUS, MALES/FEMALES PLANNING TO HAVE A CHILD & PREGNANT
    (ING 2)

==================  Physical/Chemical Properties  ==================

Melt/Freeze Pt:M.P/F.P Text:433F,223C
pH:ING 12
Solubility in Water:VERY SOL (SUPP DATA)
Appearance and Odor:WHITE TO PALE YELLOW CRYSTALLINE POWDER; SLIGHT,
    CHARACTERISTIC ODOR.

=================  Stability and Reactivity Data  =================

Stability Indicator/Materials to Avoid:YES
Hazardous Decomposition Products:TOXIC FUMES OF OXIDES OF NITROGEN AND
    HYDROGEN CHLORIDE.

====================  Disposal Considerations  ====================

Waste Disposal Methods:DISPOSE OF AS HAZ WASTE. TRANSPORT TO FED &
    STATE APPRVD FACILITY FOR TREATMENT, STOR/DISP OF HAZ WASTES. BURN
    IN CHEM INCIN EQUIPPED W/AFTERBURNER & SCRUBBER. HAZ WASTE MANIFEST
    MUST BE USED. STATE H AZ WASTE REGS MAY VARY; CHECK W/LOCAL (ING 4)

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