Synonyms: cis-dichlorodiammineplatinum (II), cis-diaminedichloroplatinum (II), cis-diamminedichloroplatinum (II), CPDD, CDDP, CACP, CPDC, DDP, DDPt, cis-ddp, neoplatin, platinol, dCDP, cis-platinous diamine dichloride, (SP-4-2)-diaminedichloroplatinum, cis-platinum(II) diamine dichloride, cisplatyl, platiblastin, PT01, Peyrone's chloride, NSC-119875, cispt(II)
Use: anti-tumor agent, antineoplastic
Molecular formula: Pt(NH₃)₂Cl₂
CAS No: 15663-27-1
EINECS No:

Physical data

Appearance: yellow crystalline solid
Melting point: ca. 270 (decomposes)
Boiling point:
Vapour density:
Vapour pressure:
Density (g cm^-3):
Flash point:
Explosion limits:
Autoignition temperature:
Water solubility: negligible

Stability

Stable. Incompatible with oxidizing agents, aluminium, antioxidants.

Toxicology

Very toxic if inhaled, swallowed, or absorbed through the skin. Many platinum compounds are sensitizers, so even low exposure may be harmful if taking place repeatedly or over an extended period. Experimental carcinogen, teratogen. IARC probable human carcinogen. May cause reproductive damage. Human mutagenic data. May cause severe allergic reaction, which may get worse with continuing exposure.

Toxicity data
(The meaning of any toxicological abbreviations which appear in this section is given here.)
IVN-HMN TDLO 72 mg kg^-1/25d/i
ORL-RAT LD50 25 mg kg^-1
IPR-RAT LD50 7 mg kg^-1
SCU-RAT LD50 8 mg kg^-1
IVN-DOG LD50 2.5 mg kg^-1
IVN-MUS LD50 11 mg kg^-1

Risk phrases
(The meaning of any risk phrases which appear in this section is given here.)
R23 R24 R25 R36 R37 R38 R45 R46 R60.

Transport information

(The meaning of any UN hazard codes which appear in this section is given here.)
Non-hazardous for air, sea and road freight.

Personal protection

Safety glasses, gloves, good ventilation. Treat as a possible carcinogen.

Safety phrases
(The meaning of any safety phrases which appear in this section is given here.)
S20 S22 S23 S24 S26 S27 S28 S36 S37 S45 S53.

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This information was last updated on September 5, 2003. We have tried to make it as accurate and useful as possible, but can take no responsibility for its use, misuse, or accuracy. We have not verified this information, and cannot guarantee that it is up-to-date.