Safety (MSDS) data for methotrexate

Safety (MSDS) data for methotrexate

Hazard: harmful


    Synonyms: N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-l-glutamic acid, 4-amino-N10-methylpteroyl-l-glutamic acid, 4-amino-10-methylfolic acid, (+)-amethopterin, amethopterin, amethopterine, antifolan, emtexate, ledertrexate, metatrexan, methylaminopterin, mexate, rheumatrex, further trade names
    Molecular formula: C20H22N8O5
    CAS No: 59-05-2
    EINECS No: 200-413-8

Physical data

    Appearance: yellow powder
    Melting point: ca. 192 C
    Boiling point:
    Vapour density:
    Vapour pressure:
    Density (g cm-3):
    Flash point:
    Explosion limits:
    Autoignition temperature:
    Water solubility: insoluble


    Stable, but light sensitive and hygroscopic. Incompatible with strong acids, strong oxidizing agents. Store at -15C or below.


    Toxic if swallowed. May cause harm to the unborn child.

    Toxicity data
    (The meaning of any toxicological abbreviations which appear in this section is given here.)
    ORL-RAT LD50 135 mg kg-1
    SCU-RAT LD50 58 mg kg-1
    Intraspinal-WMN LDLO 36 mg kg-1/15d

    Risk phrases
    (The meaning of any risk phrases which appear in this section is given here.)
    R25 R36 R38 R61.

Transport information

    (The meaning of any UN hazard codes which appear in this section is given here.)
    UN No 1544. Hazard class 6.1. Packing group III.

Personal protection

    Safety glasses, good ventilation.

    Safety phrases
    (The meaning of any safety phrases which appear in this section is given here.)
    S26 S36 S37 S45 S53.

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This information was last updated on July 22, 2004. We have tried to make it as accurate and useful as possible, but can take no responsibility for its use, misuse, or accuracy. We have not verified this information, and cannot guarantee that it is up-to-date.