Methimazole
Material Safety Data Sheet
2-Mercapto-1-methylimidazole, 98%
ACC# 30122
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Section 1 - Chemical Product and Company Identification |
MSDS Name: 2-Mercapto-1-methylimidazole, 98%
Catalog Numbers:
AC125500250, AC125501000
Synonyms:
Methimazole; 1-Methylimidazole-2-thiol; Mercazolyl; Thiamazole;
1-Methyl-2-mercaptoimidazole.
Company Identification:
Acros Organics N.V.
One Reagent Lane
Fair Lawn, NJ 07410
For information in North America, call: 800-ACROS-01
For emergencies in the US, call CHEMTREC: 800-424-9300
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Section 2 - Composition, Information on Ingredients
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| CAS# |
Chemical Name |
Percent |
EINECS/ELINCS |
| 60-56-0 |
2-Mercapto-1-methylimidazole |
98 | 200-482-4 |
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Section 3 - Hazards Identification
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EMERGENCY OVERVIEW
Appearance: white to light cream crystalline powder.
Caution! Stench. May cause allergic skin reaction.
This substance has caused adverse reproductive and fetal effects in
humans. May cause eye, skin, and respiratory tract irritation. May be
harmful if swallowed. Light sensitive. This product contains
2-Mercapto-1-methylimidazole, a chemical known to the state of
California to cause developmental effects.
Target Organs: Blood, thyroid.
Potential Health Effects
Eye:
May cause eye irritation.
Skin:
May cause skin irritation. May cause an allergic reaction in certain
individuals.
Rashes may follow high doses of methimazole.
Ingestion:
In high doses may cause gastric irritation, nausea, vomiting, fever,
skin rashes, and blood abnormalities including anemia. May be harmful
if swallowed.
May cause pain and stiffness in joints, paresthesias, headache, and
loss or depigmentation of hair.
Inhalation:
Causes irritation of the mucous membrane and upper respiratory
tract.
May cause sore throat, headache, and other effects similar to those
of ingestion.
Chronic:
Chronic exposure may cause reproductive disorders and teratogenic
effects. Laboratory experiments have resulted in mutagenic effects.
Chronic exposure can affect thyroid function. Chronic exposure may
cause blood effects.
Chronic exposure may cause blood effects, like agranulocytosis, a
symptom complex characterized by marked decrease in number of
granulocytes and by lesions of throat and other mucous membranes of
GI tract and of the skin.
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Section 4 - First Aid Measures
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Eyes:
Immediately flush eyes with plenty of water for at least 15 minutes,
occasionally lifting the upper and lower eyelids. Get medical aid imme
diately.
Skin:
Get medical aid immediately. Flush skin with plenty of water for at
least 15 minutes while removing contaminated clothing and shoes.
Wash clothing before reuse.
Ingestion:
Never give anything by mouth to an unconscious person. Get medical
aid immediately. Do NOT induce vomiting. If conscious and alert,
rinse mouth and drink 2-4 cupfuls of milk or water.
Inhalation:
Remove from exposure and move to fresh air immediately. If not
breathing, give artificial respiration. If breathing is difficult,
give oxygen. Get medical aid.
Notes to Physician:
Treat symptomatically and supportively.
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Section 5 - Fire Fighting Measures
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General Information:
As in any fire, wear a self-contained breathing apparatus in
pressure-demand, MSHA/NIOSH (approved or equivalent), and full
protective gear. During a fire, irritating and highly toxic gases
may be generated by thermal decomposition or combustion.
Extinguishing Media:
In case of fire, use water, dry chemical, chemical foam, or
alcohol-resistant foam.
Flash Point: > 100 deg C (> 212.00 deg F)
Autoignition Temperature: Not applicable.
Explosion Limits, Lower:Not available.
Upper: Not available.
NFPA Rating:
(estimated) Health: 1; Flammability: 1; Instability: 0
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Section 6 - Accidental Release Measures
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General Information: Use proper personal protective equipment as indicated
in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal
container. Wash area with soap and water. Clean up spills
immediately, observing precautions in the Protective Equipment
section. Avoid generating dusty conditions. Provide ventilation.
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Section 7 - Handling and Storage
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Handling:
Wash thoroughly after handling. Remove contaminated clothing and
wash before reuse. Use with adequate ventilation. Do not get in eyes,
on skin, or on clothing. Keep container tightly closed. Do not ingest
or inhale.
Storage:
Keep container closed when not in use. Store in a cool, dry,
well-ventilated area away from incompatible substances. Hormones and
antibiotics room. Store protected from light.
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Section 8 - Exposure Controls, Personal Protection
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Engineering Controls:
Facilities storing or utilizing this material should be equipped
with an eyewash facility and a safety shower. Use adequate
ventilation to keep airborne concentrations low.
Exposure Limits
| Chemical Name |
ACGIH |
NIOSH |
OSHA - Final PELs |
| 2-Mercapto-1-methylimidazole
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none listed
|
none listed
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none listed
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OSHA Vacated PELs:
2-Mercapto-1-methylimidazole:
No OSHA Vacated PELs are listed for this chemical.
Personal Protective Equipment
Eyes:
Wear appropriate protective eyeglasses or chemical
safety goggles as described by OSHA's eye and face
protection regulations in 29 CFR 1910.133 or European
Standard EN166.
Skin:
Wear appropriate gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to minimize
contact with skin.
Respirators:
A respiratory protection program that meets OSHA's 29
CFR 1910.134 and ANSI Z88.2 requirements or European
Standard EN 149 must be followed whenever workplace
conditions warrant respirator use.
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Section 9 - Physical and Chemical Properties
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Physical State: Crystalline powder
Appearance: white to light cream
Odor: stench
pH: ~neutral (in sol)
Vapor Pressure: Not available.
Vapor Density: Not available.
Evaporation Rate:Not available.
Viscosity: Not available.
Boiling Point: 280 deg C @ 760 mm Hg
Freezing/Melting Point:143-146 deg C
Decomposition Temperature:280 deg C
Solubility: soluble
Specific Gravity/Density:Not available.
Molecular Formula:C4H6N2S
Molecular Weight:114.16
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Section 10 - Stability and Reactivity
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Chemical Stability:
Stable under normal temperatures and pressures. Light sensitive.
Conditions to Avoid:
Light, dust generation.
Incompatibilities with Other Materials:
Strong oxidizing agents.
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, oxides of sulfur, carbon dioxide.
Hazardous Polymerization: Has not been reported.
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Section 11 - Toxicological Information
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RTECS#:
CAS# 60-56-0:
NI8615000
LD50/LC50:
CAS# 60-56-0:
Oral, mouse: LD50 =
860 mg/kg;
Oral, rat: LD50 = 2250
mg/kg;
.
Carcinogenicity:
CAS# 60-56-0:
Not listed by ACGIH, IARC, NTP, or CA Prop 65.
Epidemiology:
No data available.
Teratogenicity:
Methimazole is an antithyroid medication that is given
orally or rectally to treat hyperthyroidism. Methimazole
crosses the placenta & can produce hypothyroidism & goiter
in the offspring of treated animals & humans.
Reproductive Effects:
Adverse reproductive effects have occurred in experimental
animals.
Mutagenicity:
See actual entry in RTECS for complete information.
Neurotoxicity:
No information found
Other Studies:
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Section 12 - Ecological Information
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No information available.
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Section 13 - Disposal Considerations
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Chemical waste generators must determine whether a discarded chemical is classified
as a hazardous waste.
US EPA guidelines for the classification determination are listed in 40 CFR Parts 261.3.
Additionally, waste generators must consult state and local hazardous waste regulations to
ensure complete and accurate classification.
RCRA P-Series: None listed.
RCRA U-Series: None listed.
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Section 14 - Transport Information
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US DOT |
Canada TDG |
| Shipping Name: |
Not regulated as a hazardous material |
No information available. |
| Hazard Class: |
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| UN Number: |
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| Packing Group: |
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Section 15 - Regulatory Information
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US FEDERAL
TSCA
CAS# 60-56-0 is listed on the TSCA inventory.
Health & Safety Reporting List
None of the chemicals are on the Health & Safety Reporting List.
Chemical Test Rules
None of the chemicals in this product are under a Chemical Test Rule.
Section 12b
None of the chemicals are listed under TSCA Section 12b.
TSCA Significant New Use Rule
None of the chemicals in this material have a SNUR under TSCA.
CERCLA Hazardous Substances and corresponding RQs
None of the chemicals in this material have an RQ.
SARA Section 302 Extremely Hazardous Substances
None of the chemicals in this product have a TPQ.
SARA Codes
CAS # 60-56-0: delayed.
Section 313
No chemicals are reportable under Section 313.
Clean Air Act:
This material does not contain any hazardous air pollutants.
This material does not contain any Class 1 Ozone depletors.
This material does not contain any Class 2 Ozone depletors.
Clean Water Act:
None of the chemicals in this product
are listed as Hazardous Substances under the CWA.
None of the chemicals in this
product are listed as Priority Pollutants under the CWA.
None of the chemicals in this
product are listed as Toxic Pollutants under the CWA.
OSHA:
None of the chemicals in this product
are considered highly hazardous by OSHA.
STATE
CAS# 60-56-0 can be found on the
following state right to know lists: New Jersey.
California Prop 65
WARNING: This product contains 2-Mercapto-1-methylimidazole, a
chemical known to the state of California to cause developmental
reproductive toxicity.
California No Significant Risk Level:
None of the chemicals in this product are listed.
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols:
XN
Risk Phrases:
R 22 Harmful if swallowed.
Safety Phrases:
WGK (Water Danger/Protection)
CAS# 60-56-0: No information available.
Canada - DSL/NDSL
CAS# 60-56-0 is listed on Canada's DSL List.
Canada - WHMIS
not available.
This product has been classified in accordance with the hazard
criteria of the Controlled Products Regulations and the MSDS
contains all of the information required by those regulations.
Canadian Ingredient Disclosure List
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Section 16 - Additional Information
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MSDS Creation Date: 7/01/1999
Revision #5 Date: 10/03/2005
The information above is believed to be accurate and represents the best
information currently available to us. However, we make no warranty of
merchantability or any other warranty, express or implied, with respect to
such information, and we assume no liability resulting from its use. Users
should make their own investigations to determine the suitability of the
information for their particular purposes. In no event shall Fisher be liable
for any claims, losses, or damages of any third party or for lost profits
or any special, indirect, incidental, consequential or exemplary
damages, howsoever arising, even if Fisher has been advised of
the possibility of such damages.