Mephenamic Acid

SIGMA CHEMICAL CO -- MEFENAMIC ACID, M4267 -- 6505-00N093128
=====================  Product Identification  =====================

Product ID:MEFENAMIC ACID, M4267
MSDS Date:01/01/1999
FSC:6505
NIIN:00N093128
Status Code:A
MSDS Number: CJXLC
=== Responsible Party ===
Company Name:SIGMA CHEMICAL CO
Box:14508
City:ST LOUIS
State:MO
ZIP:63178
Country:US
Info Phone Num:314-771-5765
Emergency Phone Num:314-771-5765
CAGE:21076
=== Contractor Identification ===
Company Name:SIGMA CHEMICAL COMPANY
Address:3050 SPRUCE ST
Box:14508
City:ST LOUIS
State:MO
ZIP:63178
Country:US
Phone:314-771-5765
CAGE:21076

=============  Composition/Information on Ingredients  =============

Ingred Name:ANTHRANILIC ACID, N-(2,3-XYLYL)-; (MEFENAMIC ACID).
    LD50:(ORAL,RAT) 740 MG/KG.
CAS:61-68-7
RTECS #:CB4550000
= Wt:100.

=====================  Hazards Identification  =====================

LD50 LC50 Mixture:SEE INGREDIENTS & TOXICOLOGICAL INFO.
Routes of Entry: Inhalation:YES  Skin:YES  Ingestion:YES
Reports of Carcinogenicity:NTP:NO    IARC:NO	OSHA:NO
Health Hazards Acute and Chronic:ACUTE: HARMFUL IF SWALLOWED, INHALED
    OR ABSORBED THROUGH SKIN. MAY CAUSE IRRITATION. MAY CAUSE NERVOUS
    SYSTEM DISTURBANCES. EXPOSURE CAN CAUSE: GASTROINTESTINAL
    DISTURBANCES; BLOOD EFFECTS. CHRONIC: P OSSIBLE TERATOGEN. MAY
    CAUSE REPRODUCTIVE DISORDERS. TARGET ORGAN(S): KIDNEYS. TARGET
    ORGAN DATA: PERIPHERAL NERVE AND SENSATION (FLACCID PARALYSIS
    WITHOUT ANESTHESIA). SENSE ORGANS AND SPECIAL SENSES  (MYDRIASIS).
    BEHAVIORAL (ALTERED SLEEP TIME; SOMNOLENCE; TOXIC PSYCHOSIS;
    CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD; ATAXIA; WITHDRAWAL).
    LUNGS, THORAX OR RESPIRATION (RESPIRATORY STIMULATION). GAST
    ROINTESTINAL (CHANGES (EFTS OF OVEREXP)
Effects of Overexposure:HLTH HAZ: IN STRUCTURE OR FUNCTION OF EXOCRINE
    PANCREAS; ULCERATION OR BLEEDING FROM LARGE INTESTINE;
    HYPERMOTILITY, DIARRHEA). LIVER (LIVER FUNCTION TESTS IMPAIRED).
    KIDNEY, URETER, BLADDER (CHANGES  IN TUBULES). BLOOD (OTHER
    HEMOLYSIS WITH OR WITHOUT ANEMIA). SKIN AND APPENDAGES (AFTER
    SYSTEMIC EXPOSURE: DERMATITIS, OTHER). MATERNAL EFFECTS (MENSTRUAL
    CYCLE CHANGES OR DISORDERS). SPECIFIC DEVELOP MENTAL ABNORMALITIES
    (CRANIOFACIAL; CARDIOVASCULAR SYSTEM). NUTRITIONAL AND GROSS
    METABOLIC (CHANGES IN: K; BODY TEMPERATURE INCREASE; OTHER
    CHANGES). TUMORIGENIC (ACTIVE AS ANTI-CANCER AGENT).

=======================  First Aid Measures  =======================

First Aid:INGESTION: WASH OUT MOUTH WITH WATER PROVIDED PERSON IS
    CONSCIOUS. CALL MD. SKIN: FLUSH WITH COPIOUS AMOUNTS OF WATER FOR
    AT LEAST 15 MINUTES. REMOVE CONTAMINATED CLOTHING AND SHOES. CALL
    MD. INHALATI ON: REMOVE TO FRESH AIR. IF BREATHING BECOMES
    DIFFICULT, CALL MD. EYES: FLUSH WITH COPIOUS AMOUNTS OF WATER FOR
    AT LEAST 15 MINUTES. ASSURE ADEQUATE FLUSHING BY SEPARATING THE
    EYELIDS WITH FINGERS. CA LL MD.

=====================  Fire Fighting Measures  =====================

Extinguishing Media:CARBON DIOXIDE, DRY CHEMICAL POWDER OR APPROPRIATE
    FOAM.
Fire Fighting Procedures:USE NIOSH APPROVED SCBA AND FULL PROTECTIVE
    EQUIPMENT .
Unusual Fire/Explosion Hazard:EMITS TOXIC FUMES UNDER FIRE CONDITIONS.

==================  Accidental Release Measures  ==================

Spill Release Procedures:WEAR NIOSH APPROVED RESPIRATOR, CHEMICAL
    SAFETY GOGGLES, RUBBER BOOTS AND HEAVY RUBBER GLOVES. SWEEP UP,
    PLACE IN A BAG AND HOLD FOR WASTE DISPOSAL. AVOID RAISING DUST.
    VENTILATE AREA AND WASH SPILL S ITE AFTER MATERIAL PICKUP IS
    COMPLETE.

======================	Handling and Storage  ======================

Handling and Storage Precautions:HARMFUL. HARMFUL BY INHALATION, IN
    CONTACT WITH SKIN AND IF SWALLOWED. DO NOT BREATHE DUST.
Other Precautions:POSSIBLE RISK OF IRREVERSIBLE EFFECTS. POSSIBLE
    TERATOGEN. REPRODUCTIVE HAZARD. NEUROLOGICAL HAZARD.

=============  Exposure Controls/Personal Protection  =============

Respiratory Protection:WEAR APPROPRIATE NIOSH APPROVED RESPIRATOR.
Ventilation:MECHANICAL EXHAUST REQUIRED.
Protective Gloves:CHEMICAL-RESISTANT GLOVES.
Eye Protection:ANSI APPROVED CHEMICAL WORKERS GOGGLES .
Other Protective Equipment:ANSI APPROVED EMERGENCY EYE WASH AND DELUGE
    SHOWER . WEAR SUITABLE OTHER PROTECTIVE CLOTHING.
Supplemental Safety and Health
MFR'S INFORMATION ON INGREDIENTS: MF: C15H15NO2. EC NO: 200-513-1. --
    PHYSICAL AND CHEMICAL PROPERTIES: SOLUBILITY: IN AMMONIUM -
    SOLUBLE.

==================  Physical/Chemical Properties  ==================

Solubility in Water:SUPP DATA
Appearance and Odor:SOLID.

=================  Stability and Reactivity Data  =================

Stability Indicator/Materials to Avoid:YES
Hazardous Decomposition Products:TOXIC FUMES OF: CARBON MONOXIDE,
    CARBON DIOXIDE, NITROGEN OXIDES.
Conditions to Avoid Polymerization:WILL NOT OCCUR.

===================  Toxicological Information	===================

Toxicological Information:TOXICITY DATA: LDLO:(ORAL,WMN) 280 MG/KG/2W-I
    - DRSAEA 6,230,1991. LD50:(ORAL,RAT) 740 MG/KG - TOIZAG 28,99,1981.
    LD50:(IPR,RAT) 327 MG/KG - TXAPA9 18,185,1971. LD50:(IVN,RAT) 112
    MG/KG; LD50:(IVN,CAT ) 100 MG/KG - CMROCX 4,17,1976.
    LD50:(ORAL,MUS) 525 MG/KG. - JNPHAG 2,259,1971. LD50:(IPR,MUS) 120
    MG/KG - ARZNAD 19,36,1969. LD50:(IVN,MUS) 96 MG/KG - YKKZAJ
    89,1392,1969. LD50:(IMS,MUS) 400 MG/KG -  PCJOAU 17,353,1983. ONLY
    SELECTED REGISTRY OF TOXIC EFFECTS OF CHEMICAL SUBSTANCES (RTECS)
    DATA IS PRESENTED HERE. SEE ACTUAL ENTRY IN RTECS FOR COMPLETE
    INFORMATION.

=====================  Ecological Information  =====================

Ecological:DATA NOT YET AVAILABLE.

====================  Disposal Considerations  ====================

Waste Disposal Methods:DISSOLVE OR MIX THE MATERIAL WITH A COMBUSTIBLE
    SOLVENT AND BURN IN A CHEMICAL INCINERATOR EQUIPPED WITH AN
    AFTERBURNER AND SCRUBBER. OBSERVE ALL FEDERAL, STATE AND LOCAL
    ENVIRONMENTAL REGULATIONS.

===================  MSDS Transport Information  ===================

Transport Information:CONTACT SIGMA CHEMICAL COMPANY FOR TRANSPORTATION
    INFORMATION.

=====================  Regulatory Information  =====================

Federal Regulatory Information:EUROPEAN INFORMATION: HARMFUL; R
    20/21/22 - HARMFUL BY INHALATION, IN CONTACT WITH SKIN AND IF
    SWALLOWED. R 40 - POSSIBLE RISK OF IRREVERSIBLE EFFECTS. S 22 - DO
    NOT BREATHE DUST. S 36 - WEAR SUITABLE  PROTECTIVE CLOTHING.

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