Mechlorethamine

MERCK,SHARP & DOHME -- MUSTARGEN -- 6505-01-146-2629
=====================  Product Identification  =====================

Product ID:MUSTARGEN
MSDS Date:07/10/1986
FSC:6505
NIIN:01-146-2629
MSDS Number: BGNWM
=== Responsible Party ===
Company Name:MERCK,SHARP & DOHME
Address:SUMNEYTOWN PIKE
City:WEST POINT
State:PA
ZIP:19486
Country:US
Info Phone Num:215-661-5000
Emergency Phone Num:215-661-7300
CAGE:NO055
=== Contractor Identification ===
Company Name:MERCK,SHARP & DOHME
Address:SUMNEYTOWN PIKE
Box:City:WEST POINT
State:PA
ZIP:19486
Country:US
Phone:215-661-5000
CAGE:NO055
Company Name:MERCK-SHARP AND DOHME DIV OF MERCK AND CO INC
Address:SUMNEYTOWN PIKE
Box:City:WEST POINT
State:PA
ZIP:19486
Country:US
Phone:215-540-8629
CAGE:06990

=============  Composition/Information on Ingredients  =============

Ingred Name:MECHLORETHAMINE HYDROCHLORIDE
CAS:55-86-7
RTECS #:IA2100000
Fraction by Wt: 9%
Other REC Limits:0-SEE SUPPLEMTL DATA
OSHA PEL:SEE MFR REC LIMIT
ACGIH TLV:SEE MFR REC LIMIT

Ingred Name:SODIUM CHLORIDE
CAS:7647-14-5
RTECS #:VZ4725000
Fraction by Wt: 91%
OSHA PEL:N/D
ACGIH TLV:N/D

=====================  Hazards Identification  =====================

Routes of Entry: Inhalation:YES  Skin:YES  Ingestion:YES
Reports of Carcinogenicity:NTP:UNKNOWN	  IARC:YES
Health Hazards Acute and Chronic:CYTOTOXIC TO PROLIFERATING CELLS;CAN
    CAUSE MUTATIONS IN VARIETY OF GENOTOXICITY TESTS;IS EMBYROTOXIC &
    TERATOGENIC IN RATS.
Effects of Overexposure:EYE-CORROSIVE. SKIN-CORROSIVE &
    POWERFULVESICANT. INHAL-IRRIT TO MUCOUS MEMBRANES OF RESPIRATORY
    TRACT. INGEST-EFFECT ON HUMANS NOT KNOWN;PROBABLE IRRIT TO UPPER
    G.I. TRACT.

=======================  First Aid Measures  =======================

First Aid:EYE-FLUSH WELL W/WATER;GET IMMED MED ATTN. SKIN-WASH W/SOAP &
    WATER 5 MIN,FOLLOWED BY 2% SODIUM THIOSULFATE. DO NOT USE ORGANIC
    SOLVENTS. INHAL-GET TO FRESH AIR;MAINTAIN AIRWAY;GET MED ATTN IF
    REQD. I NGEST-DO NOT INDUCE VOMITING. MAY DILUTEW/WATER;GET MED
    ATTN.

=====================  Fire Fighting Measures  =====================

Flash Point:NONE
Extinguishing Media:WATER SPRAY OR ALL PURPOSE DRY CHEMICAL
Fire Fighting Procedures:USE SELF-CONTND BREATHING APPARATUS & FULL
    PROTECTIVE CLOTH IF VIALS INVOLVED IN FIRE & CONTENTS
    RELEASED/BURNING
Unusual Fire/Explosion Hazard:DANGEROUS WHEN HEATED TO DECOMP;EMITS
    HIGHLY TOXIC FUMES CONTAINING CHLORIDES & NO*2.

==================  Accidental Release Measures  ==================

Spill Release Procedures:AVOID CREATING AIRBORNE DUST. WEAR
    GLOVES,GOGGLES,AIRLINE MASK,LONG SLEEVED WORK UNIFORM & SHOE
    PROTECTORS.
Neutralizing Agent:MIX OF 5% SODIUM THIOSULFATE & 5% SODIUM
    BICARBONATE.

======================	Handling and Storage  ======================

Handling and Storage Precautions:STORE IN COOL DRY PLACE.
    DRY,CRYSTALLINE MATL STABLE AT TEMPS UP TO 40C. KEEP CONTNRS CLOSED
    & WELL SEALED.
Other Precautions:PREFERABLE TO HANDLE MATL IN DISSOLVED STATE.
    EMPHASIZE CONTROL BY CONTAINMENT.

=============  Exposure Controls/Personal Protection  =============

Respiratory Protection:AIRLINE RESPIRATOR OR SELF-CONTAINED BREATHING
    APPARATUS IF EXPOSED TO AIRBORNE DUST.
Ventilation:AS REQD TO REMOVE AIRBORNE DUST. ALSO RECOMMEND HEPA
    FILTER. VENT NOT REQD IF MATL CONTAINED IN VIAL.
Protective Gloves:RUBBER OR IMPERVIOUS MATL.
Eye Protection:CHEM GOGGLES.
Other Protective Equipment:LONG-SLEEVED WORK UNIFORM,PREFERABLY MADE OF
    DISPOSABLE MATL.
Supplemental Safety and Health
MFR RECOMMENDATION OF ZERO EXPOSURE IS AN INTERNALLY DERIVED EXPOSURE
    CONTROL BASED ON THE CARCINOGENIC POTENTIAL OF THE COMPOUND.

==================  Physical/Chemical Properties  ==================

HCC:T3
Melt/Freeze Pt:M.P/F.P Text:109-111C
Solubility in Water:APPRECIABLE
Appearance and Odor:WHITE CRYSTALLINE HYGROSCOPIC POWDER

=================  Stability and Reactivity Data  =================

Stability Indicator/Materials to Avoid:NO
NEUTRAL OR ALKALINE AQUEOUS SOLUTION.
Stability Condition to Avoid:MATL IS HYGROSCOPIC-PROTECT FM CONTACT
    W/MOISTURE.
Hazardous Decomposition Products:NONE

====================  Disposal Considerations  ====================

Waste Disposal Methods:IAW LOCAL,STATE & FED REGS. INCINERATION IS
    PREFERRED METHOD. SMALL AMTS & EQUIP CAN BE CLEANED BY SOAKING WITH
    AQUEOUS SOLN CONTAINING EQUAL VOLS OF 5% SODIUM THIOSULFATE & 5%
    SODIUM BICARBONATE FOR  45 MIN.

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