WYETH-AYERST LABORATORIES -- 04536 LEUCOVORIN CALCIUM TABLETS 5 MG -- 6505-01-230-3140
===================== Product Identification =====================
Product ID:04536 LEUCOVORIN CALCIUM TABLETS 5 MG
MSDS Date:05/01/1991
FSC:6505
NIIN:01-230-3140
MSDS Number: BWXVM
=== Responsible Party ===
Company Name:WYETH-AYERST LABORATORIES
Box:8299
City:PHILADELPHIA
State:PA
ZIP:19101-5000
Country:US
Info Phone Num:610-902-5171
Emergency Phone Num:610-902-5171
CAGE:0HMG4
=== Contractor Identification ===
Company Name:WYETH-AYERST LABORATORIES
Box:City:PHILADELPHIA
State:PA
ZIP:19101-5000
Country:US
Phone:610-902-5171
CAGE:0HMG4
============= Composition/Information on Ingredients =============
Ingred Name:LEUCOVORIN CALCIUM *95-1*
CAS:1492-18-8
RTECS #:MA0600500
Fraction by Wt: 2-7%
===================== Hazards Identification =====================
LD50 LC50 Mixture:ORAL LD50 (RAT): >8000 MG/KG (SEE SUPP)
Routes of Entry: Inhalation:YES Skin:NO Ingestion:NO
Reports of Carcinogenicity:NTP:NO IARC:NO OSHA:NO
Health Hazards Acute and Chronic:CALCIUM LEUCOVORIN-LOW ORDER OF
TOXICITY. ALLERGIC REACTIONS HAVE BEEN REPORTED FOLLOWING
ORAL/INTRAVENOUS ADMINISTRATION.
Explanation of Carcinogenicity:NONE
Effects of Overexposure:CALCIUM LEUCOVORIN-LOW ORDER OF TOXICITY.
ALLERGIC REACTIONS HAVE BEEN REPORTED FOLLOWING ORAL/INTRAVENOUS
ADMINISTRATION.
======================= First Aid Measures =======================
First Aid:EYES: IMMEDIATELY FLUSH W/PLENTY OF COOL, LOW-PRESSURE WATER
FOR 20 MINS. SKIN: PROMPTLY WASH W/SOAP & COOL RUNNING WATER.
INHALATION: REMOVE TO FRESH AIR. GIVE CPR/OXYGEN IF NEEDED.
INGESTION: DON'T INDUCE VOMITING EXCEPT AS DIRECTED BY MEDICAL
PERSONNEL. DON'T INDUCE VOMITING/GIVE ANYTHING BY MOUTH IF
UNCONSCIOUS. OBTAIN MEDICAL ATTENTION IN ALL CASES.
================== Accidental Release Measures ==================
Spill Release Procedures:WEAR DISPOSABLE COVERALLS, RUBBER GLOVES & A
DISPOSABLE DUST MASK/APPROVED AIR-PURIFYING RESPIRATOR
W/HIGH-EFFICIENCY CARTRIDGES. CONTAIN & COLLECT.
====================== Handling and Storage ======================
Handling and Storage Precautions:KEEP CONTAINER CLOSED WHEN NOT IN USE.
MINIMIZE EXCESS HANDLING.
============= Exposure Controls/Personal Protection =============
Respiratory Protection:WEAR AN APPROVED AIR-PURIFYING RESPIRATOR
W/HIGH-EFFICIENCY CARTRIDGES ADEQUATE TO CONTROL EXPOSURE IF PEL IS
EXCEEDED.
Ventilation:CLOSED-SYSTEM HANDLING, LABORATORY BENCH HOOD/LOCAL EXHAUST
TO CONTROL DUST/MIST.
Protective Gloves:RUBBER
Eye Protection:RECOMMENDED
Work Hygienic Practices:WASH HANDS & FACE AFTER HANDLING.
REMOVE/LAUNDER CONTAMINATED CLOTHING BEFORE REUSE.
Supplemental Safety and Health
ORAL LD50 INFORMATION IS FOR CALCIUM LEUCOVORIN.
================== Physical/Chemical Properties ==================
Decomp Temp:Decomp Text:473F
Solubility in Water:COMPLETE
Appearance and Odor:YELLOWISH-WHITE TABLETS; ROUND, SQUARE/OVAL.
================= Stability and Reactivity Data =================
Stability Indicator/Materials to Avoid:YES
Hazardous Decomposition Products:CO/CO2/NITROGEN OXIDES/IRRITATING
ALDEHYDES/KETONES/ORGANIC ACIDS/HYDROGEN CYANIDE.
==================== Disposal Considerations ====================
Waste Disposal Methods:DISPOSE OF IAW/FEDERAL, STATE & LOCAL
REGULATIONS. INCINERATION IS RECOMMENDED.
Disclaimer (provided with this information by the compiling agencies):
This information is formulated for use by elements of the Department
of Defense. The United States of America in no manner whatsoever,
expressly or implied, warrants this information to be accurate and
disclaims all liability for its use. Any person utilizing this
document should seek competent professional advice to verify and
assume responsibility for the suitability of this information to their
particular situation.