Grisofulvin

MSDS Language: EN
Country:
                      **** MATERIAL SAFETY DATA SHEET ****

  (+)-Griseofulvin, 97%

        **** SECTION 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION ****

MSDS Name: (+)-Griseofulvin, 97%
Catalog Numbers:
     22745-0000, 22745-0050, 22745-0250, 22745-1000
Synonyms:
Company Identification (Europe):  Acros Organics BVBA
                                  Janssen Pharmaceuticalaan 3a
                                  2440 Geel, Belgium
Company Identification (USA):     Acros Organics
                                  One Reagent Lane
                                  Fairlawn, NJ  07410
For information in North America, call:   800-ACROS-01
For information in Europe, call:          0032(0) 14575211
For emergencies in the US, call CHEMTREC: 800-424-9300
For emergencies in Europe, call:     0032(0) 14575299

          **** SECTION 2 - COMPOSITION, INFORMATION ON INGREDIENTS ****

+----------------+--------------------------------------+----------+-----------+-----------+---------------+
|      CAS#      |              Chemical Name           |    %     |  EINECS#  |Haz Symbols| Risk Phrases  |
|----------------|--------------------------------------|----------|-----------|-----------|---------------+
|      126-07-8  |(+)-Griseofulvin                      |   97%    | 204-767-4 |||
+----------------+--------------------------------------+----------+-----------+-----------+---------------+
          Hazard Symbols: XN
          Risk Phrases: 33

                  **** SECTION 3 - HAZARDS IDENTIFICATION ****

                               EMERGENCY OVERVIEW
Danger of cumulative effects.Cancer suspect agent.

Potential Health Effects
     Eye:
          May cause eye irritation.
     Skin:
          May cause skin irritation. Harmful if absorbed through the skin.
     Ingestion:
          Harmful if swallowed. May cause irritation of the digestive tract.
     Inhalation:
          Harmful if inhaled. May cause respiratory tract irritation.
     Chronic:
          Not available.

                    **** SECTION 4 - FIRST AID MEASURES ****

     Eyes:
          Immediately flush eyes with plenty of water for at least 15 minutes,
          occasionally lifting the upper and lower eyelids.
     Skin:
          Flush skin with plenty of water for at least 15 minutes while
          removing contaminated clothing and shoes.
     Ingestion:
          Get medical aid. Wash mouth out with water.
     Inhalation:
          Remove from exposure and move to fresh air immediately.
     Notes to Physician:

                  **** SECTION 5 - FIRE FIGHTING MEASURES ****

     General Information:
          As in any fire, wear a self-contained breathing apparatus in
          pressure-demand, MSHA/NIOSH (approved or equivalent), and full
          protective gear.
     Extinguishing Media:
          In case of fire, use water, dry chemical, chemical foam, or
          alcohol-resistant foam.

                **** SECTION 6 - ACCIDENTAL RELEASE MEASURES ****

     General Information: Use proper personal protective equipment as indicated
                          in Section 8.
     Spills/Leaks:
          Sweep up, then place into a suitable container for disposal.

                   **** SECTION 7 - HANDLING and STORAGE ****

     Handling:
          Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin
          and eyes.
     Storage:
          Store in a cool, dry place. Store in a tightly closed container.
          Hormones and antibiotics room.

          **** SECTION 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION ****

     Engineering Controls:
          Use adequate ventilation to keep airborne concentrations low.
     Personal Protective Equipment

                 Eyes:
                       Wear chemical goggles.
                 Skin:
                       Wear appropriate protective gloves and clothing to
                       prevent skin exposure.
             Clothing:
                       Wear appropriate protective clothing to minimize
                       contact with skin.
          Respirators:
                       Wear a NIOSH/MSHA or European Standard EN 149
                       approved full-facepiece airline respirator in the
                       positive pressure mode with emergency escape
                       provisions.

             **** SECTION 9 - PHYSICAL AND CHEMICAL PROPERTIES ****

Physical State:             Powder
Color:                      white to yellow white
Odor:                       Not available.
pH:                         Not available.
Vapor Pressure:             Not available.
Viscosity:                  Not available.
Boiling Point:              Not available.
Freezing/Melting Point:     217.00 - 224.00 deg C
Autoignition Temperature:   Not available.
Flash Point:                Not available.
Explosion Limits, lower:    Not available.
Explosion Limits, upper:    Not available.
Decomposition Temperature:
Solubility in water:        Not available.
Specific Gravity/Density:
Molecular Formula:
Molecular Weight:           352.76

                 **** SECTION 10 - STABILITY AND REACTIVITY ****

     Chemical Stability:
          Stable under normal temperatures and pressures.
     Conditions to Avoid:
          Incompatible materials.
     Incompatibilities with Other Materials:
          Strong oxidizing agents.
     Hazardous Decomposition Products:
          Hydrogen chloride, carbon monoxide, irritating and toxic fumes and
          gases, carbon dioxide.
     Hazardous Polymerization: Has not been reported.

                **** SECTION 11 - TOXICOLOGICAL INFORMATION ****

     RTECS#:
          CAS# 126-07-8: WG9800000
     LD50/LC50:
          CAS# 126-07-8: Oral, mouse: LD50 = >50 gm/kg; Oral, rat: LD50 = >10
          gm/kg.
     Carcinogenicity:
       (+)-Griseofulvin -
          California: carcinogen; initial date 1/1/90
                OSHA: Possible Select carcinogen
                IARC: Group 2B carcinogen
          See actual entry in RTECS for complete information.

                  **** SECTION 12 - ECOLOGICAL INFORMATION ****



                 **** SECTION 13 - DISPOSAL CONSIDERATIONS ****

Dispose of in a manner consistent with federal, state, and local regulations.

                  **** SECTION 14 - TRANSPORT INFORMATION ****

     IATA
          No information available.
     IMO
          No information available.
     RID/ADR
          No information available.

                  **** SECTION 15 - REGULATORY INFORMATION ****

 European/International Regulations
     European Labeling in Accordance with EC Directives
          Hazard Symbols: XN
          Risk Phrases:
                       R 33  Danger of cumulative effects.
          Safety Phrases:
                       S 22  Do not breathe dust.
                       S 24/25  Avoid contact with skin and eyes.
   WGK (Water Danger/Protection)
          CAS# 126-07-8: 2
   United Kingdom Occupational Exposure Limits

   United Kingdom Maximum Exposure Limits

   Canada
          None of the chemicals in this product are listed on the DSL/NDSL list.
          CAS# 126-07-8 is not listed on Canada's Ingredient Disclosure List.
   Exposure Limits
 US FEDERAL
     TSCA
          CAS# 126-07-8 is not listed on the TSCA inventory.
          It is for research and development use only.

                  **** SECTION 16 - ADDITIONAL INFORMATION ****

     MSDS Creation Date:  7/16/1996  Revision #0 Date: Original.

     The information above is believed to be accurate and represents the best
     information currently available to us. However, we make no warranty of
     merchantability or any other warranty, express or implied, with respect to
     such information, and we assume no liability resulting from its use. Users
     should make their own investigations to determine the suitability of the
     information for their particular purposes. In no way shall the company be
     liable for any claims, losses, or damages of any third party or for lost
     profits or any special, indirect, incidental, consequential or exemplary
     damages, howsoever arising, even if the company has been advised of
     the possibility of such damages.
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