SMITHKLINE BECKMAN CORP -- KYTRIL INJECTION -- 6505-01-391-6108
===================== Product Identification =====================
Product ID:KYTRIL INJECTION
MSDS Date:01/25/1994
FSC:6505
NIIN:01-391-6108
MSDS Number: BXPFC
=== Responsible Party ===
Company Name:SMITHKLINE BECKMAN CORP
Address:709 SWEDELAND RD
Box:1539
City:KING OF PRUSSIA
State:PA
ZIP:19406-5000
Country:US
Info Phone Num:215-270-7807/215-270-6110
Emergency Phone Num:215-270-6110/215-270-7807
CAGE:0DU85
=== Contractor Identification ===
Company Name:SMITHKLINE BECKMAN CORP.
Address:1 FRANKLIN PLZ
Box:1539
City:PHILADELPHIA
State:PA
ZIP:19101
Country:US
Phone:215-751-4000
CAGE:0DU85
Company Name:SMITHKLINE BEECHAM PHARMACEUTICALS RESEARCH & DEVE
Address:709 SWEDELAND RD
Box:1539
City:KING OF PRUSSIA
State:PA
ZIP:19406
Country:US
Phone:215-270-6110
CAGE:0P1L6
============= Composition/Information on Ingredients =============
Ingred Name:GRANISETRON HYDROCHLORIDE *95-2*
CAS:107007-99-8
RTECS #:NK7882200
Fraction by Wt: 0.3%
Ingred Name:SODIUM CHLORIDE
CAS:7647-14-5
RTECS #:VZ4725000
Fraction by Wt: 0.9%
Ingred Name:WATER
CAS:7732-18-5
RTECS #:ZC0110000
Fraction by Wt: <98%
===================== Hazards Identification =====================
LD50 LC50 Mixture:ORAL LD50 (RAT): >2000 MG/KG
Routes of Entry: Inhalation:YES Skin:NO Ingestion:YES
Reports of Carcinogenicity:NTP:NO IARC:NO OSHA:NO
Health Hazards Acute and Chronic:EYES: IRRITATION FOLLOWING DIRECT
CONTACT W/THIS MATERIAL.
Explanation of Carcinogenicity:NONE
Effects of Overexposure:IRRITATION, REDNESS, SWELLING, BLURRED VISION,
PAIN, HEADACHE, DROWSINESS, LETHARGY, WEAKNESS, THIRST.
======================= First Aid Measures =======================
First Aid:SKIN/EYES: FLUSH IMMEDIATELY W/WATER FOR 15 MINS. INHALATION:
REMOVE TO FRESH AIR. GIVE CPR IF NEEDED. OBTAIN MEDICAL ATTENTION
IN ALL CASES. NOTE TO PHYSICIAN: THIS MATERIAL IS A
5-HYDROXYTRYPTAMINE- 3 ANTAGONIST W/NO SPECIFIC,
RECOMMENDEDANTIDOTES. MEDICAL TREATMENT SHOULD BE SYMPTOMATIC &
SUPPORTIVE.
===================== Fire Fighting Measures =====================
Flash Point:NON-FLAMMABLE
Fire Fighting Procedures:WEAR SCBA & FULL PROTECTIVE EQUIPMENT. SAFELY
MOVE CONTAINER FROM AREA. DIKE AREA IF POSSIBLE FOR LATER DISPOSAL.
Unusual Fire/Explosion Hazard:TOXIC/CORROSIVE GASES ARE EXPECTED IN
FIRES INVOLVING THIS MIXTURE.
================== Accidental Release Measures ==================
Spill Release Procedures:LARGE: WEAR PROTECTIVE CLOTHING/EQUIPMENT
CONSISTENT W/DEGREE OF HAZARD. SPREAD A SUITABLE INERT
ABSORBENT/THEN CAREFULLY SCOOP UP & PLACE IN A SUITABLE/PROPERLY
LABELED CONTAINER FOR RECOVERY/DISPOSA L. WATER MAY BE USED FOR
DECONTAMINATION/CLEANUP.
====================== Handling and Storage ======================
Handling and Storage Precautions:KEEP IN TIGHTLY SEALED CONTAINERS.
AVOID PROLONGED STORAGE AT ELEVATED TEMPS (> 68F), FREEZING
CONDITIONS.
Other Precautions:AVOID BREATHING MIST/VAPOR, EYE/SKIN CONTACT &
INGESTION.
============= Exposure Controls/Personal Protection =============
Respiratory Protection:NONE REQUIRED FOR NORMAL USE OF THIS MIXTURE.
Protective Gloves:RECOMMENDED
Eye Protection:RECOMMENDED
Other Protective Equipment:PROTECTIVE CLOTHING W/LONG SLEEVES, EYE WASH
STATION.
Work Hygienic Practices:REMOVE/LAUNDER CONTAMINATED CLOTHING BEFORE
REUSE. WASH THOROUGHLY AFTER HANDLING.
Supplemental Safety and Health
THIS COMPOUND ISN'T CONSIDERED TO BE READILY BIODEGRADABLE. SPILLS
CONT'D: WASH AREA W/COPIOUS AMOUNTS OF WATER.
================== Physical/Chemical Properties ==================
Boiling Pt:B.P. Text: 212F
Melt/Freeze Pt:M.P/F.P Text: 32F
Vapor Pres:NEGLIGIBLE
Vapor Density:NEGLIGIBLE
Solubility in Water:COMPLETE
Appearance and Odor:CLEAR/COLORLESS/STERILE/NONPYROGENIC/AQUEOUS
SOLUTION FOR INTRAVENOUS INJECTION
Percent Volatiles by Volume:>98
================= Stability and Reactivity Data =================
Stability Indicator/Materials to Avoid:YES
Stability Condition to Avoid:HEAT, FREEZING, DIRECT SUNLIGHT & OTHER
IGNITION SOURCES.
Hazardous Decomposition Products:IN FIRE: TOXIC/CORROSIVE GASES.
==================== Disposal Considerations ====================
Waste Disposal Methods:COLLECT FOR RECYCLING/RECOVERY IF POSSIBLE.
DISPOSE OF IAW/FEDERAL, STATE & LOCAL REGULATIONS.
Disclaimer (provided with this information by the compiling agencies):
This information is formulated for use by elements of the Department
of Defense. The United States of America in no manner whatsoever,
expressly or implied, warrants this information to be accurate and
disclaims all liability for its use. Any person utilizing this
document should seek competent professional advice to verify and
assume responsibility for the suitability of this information to their
particular situation.