Gadodiamide hydrate

STERLING WINTHROP INC. -- OMNISCAN -- -
=====================  Product Identification  =====================

Product ID:OMNISCAN
MSDS Date:10/01/1992
FSC:NIIN:Submitter:F BT
Status Code:A
MSDS Number: CLBPC
=== Responsible Party ===
Company Name:STERLING WINTHROP INC.
Address:90 PARK AVE
City:NEW YORK
State:NY
ZIP:10016
Country:US
Info Phone Num:212-907-2000
Emergency Phone Num:212-907-2000
CAGE:0X7D0
=== Contractor Identification ===
Company Name:STERLING WINTHROP INC.
Address:90 PARK AVE
Box:City:NEW YORK
State:NY
ZIP:10016
Country:US
Phone:212-907-2000
CAGE:0X7D0

=============  Composition/Information on Ingredients  =============

Ingred Name:GADODIAMIDE
CAS:122795-43-1
Fraction by Wt: 287% MG/ML

Ingred Name:CALDIAMIDE SODIUM
CAS:122760-91-2
Fraction by Wt: 12% MG/ML

Ingred Name:HYDROCHLORIC ACID
CAS:7647-01-0
RTECS #:MW4025000
Fraction by Wt: PH ADJUST
OSHA PEL:C7 MG/M3;C5 PPM
ACGIH STEL:C7.5 MG/M3;C5 PPM
EPA Rpt Qty:5000 LBS
DOT Rpt Qty:5000 LBS

Ingred Name:SODIUM HYDROXIDE
CAS:1310-73-2
RTECS #:WB4900000
Fraction by Wt: PH ADJUST
OSHA PEL:2 MG/M3
ACGIH STEL:C2 MG/M3
EPA Rpt Qty:1000 LBS
DOT Rpt Qty:1000 LBS

Ingred Name:WATER
CAS:7732-18-5
RTECS #:ZC0110000

=====================  Hazards Identification  =====================

LD50 LC50 Mixture:19.7 G/KG MOUSE
Health Hazards Acute and Chronic:LOW HEALTH HAZARD. LOW TOXIC HAZARD.
    LOW INGESTION HAZARD.
Effects of Overexposure:CHRONIC EXPOSURE INFORMATION BASED ON THE
    TOXICOLOGICAL PROPERTIES OF THE FORMULATION BY INTRAVENOUS
    INJECTION: MODERATE CHRONIC TOXICITY. MAY CAUSE KIDNEY DAMAGE.
    SUBACUTE GASTRITIS, TESTICULAR GIANT  CELL DEGENERATION & SEVERE
    DERMATITIS MAY RESULT FROM ZINC DEFICIENCY DUE TO CHELATION BY
    CALDIAMIDE SODIUM.

=======================  First Aid Measures  =======================

First Aid:INHALATION: REMOVE TO FRESH AIR.  EYES: FLUSH WITH WATER FOR
    AT LEAST 15 MINUTES.  SKIN: WASH AREA WITH SOAP AND WATER
    IMMEDIATELY.  INGESTION: IMMEDIATELY GIVE LARGE AMOUNTS OF WATER. 
    IN ALL CASES,  SEEK IMMEDIATE MEDICAL ATTENTION!  NOTE TO
    PHYSICIAN: GENERAL ADVERSE REACTIONS TO IMAGING AGENTS ARE MILD TO
    MODERATE IN NATURE.

=====================  Fire Fighting Measures  =====================

Unusual Fire/Explosion Hazard:THIS INFORMATION IS AQUEOUS BASED AND
    DOES NOT PRESENT ANY SIGNIFICANT FIRE AND EXPLOSION HAZARDS.

==================  Accidental Release Measures  ==================

Spill Release Procedures:WEAR PROTECTIVE EQUIPMENT TO AVOID INHALATION
    OR EYE/SKIN CONTACT.  STOP THE SOURCE OF RELEASE.  SMALL SPILLS MAY
    BE FLUSHED INTO SANITARY SEWER WITH COPIOUS AMOUNTS OF WATER. 
    LARGE SPILLS MUST BE CO NTAINED AS WASTE MATERIALS.

======================	Handling and Storage  ======================

Handling and Storage Precautions:AVOID BREATHING AEROSOL, AND AVOID
    CONTACT WITH EYES, SKIN, AND CLOTHING.  KEEP CONTAINER CLOSED AND
    PROTECT FROM CONTAMINATION.  STORE IN A COOL, DRY PLACE.  KEEP FROM
    FREEZING.  LABEL ALL CONTAINERS  WITH HAZARD INFORMATION WHENEVER
    THE SUBSTANCE IS TRANSFERRED FROM ORIGINAL CONTAINER.
Other Precautions:THIS FORMULATION IS AQUEOUS BASED & DOESN'T PRESENT
    ANY SIGNIFICANT FIRE & EXPLOSION OR REACTIVITY HAZARDS.

=============  Exposure Controls/Personal Protection  =============

Respiratory Protection:IF ENGINEERING CONTROLS DO NOT MAINTAIN AIRBORNE
    CONCENTRATIONS BELOW EXPOSURE CONCENTRATIONS, AN APPROVED
    RESPIRATOR SHOULD BE WORN.	MANAGERS ASSIGNING THE USE OF
    RESPIRATORS MUST ENSURE COMPLIANCE	WITH THE ELEMENTS OF
    RESPIRATORY PROTECTION REQUIREMENTS.
Ventilation:USE PROCESS ENCLOSURES, LOCAL EXHAUST VENTILATION, OR OTHER
    ENGINEERING CONTROLS TO CONTROL THE GENERATION OF AEROSOL BELOW
    EXPOSURE LIMITS.
Other Protective Equipment:EYE BATH, SAFETY SHOWER, AND WASHING
    FACILITIES SHOULD BE READILY AVAILABLE IN THE IMMEDIATE AREA.
Work Hygienic Practices:GOOD INDUSTRIAL PRACTICE SHOULD BE FOLLOWED,
    WHICH INCLUDES PREVENTING CONTACT.
Supplemental Safety and Health

==================  Physical/Chemical Properties  ==================

pH:5.5-7.0
Viscosity:@ 20 DEG C: 2.0
Appearance and Odor:CLEAR LIQUID

===================  Toxicological Information	===================

Toxicological Information:EXPECTED TO HAVE LOW TOXICITY. GENERAL
    ADVERSE REACTIONS IN HUMANS AND ANIMAL STUDIES WERE MILD TO
    MODERATE IN NATURE. THESE MAY INCLUDE NAUSEA, VOMITING,
    CARDIOVASCULAR EFFECTS, DIZZINESS, HEADACHE,  AND KIDNEY EFFECTS.
    ONLY KIDNEY EFFECTS ARE THOUGHT TO BE DUE TO THE DRUG ITSELF.
    HEADACHE, LIGHTHEADEDNESS, DIZZINESS, DROWSINESS, AND NAUSEA ARE
    LIKELY RELATED TO THE HYPERTONIC PROPERTIES OF THE FO RMULATION
    ADMINISTERED VIA THE INTRAVENOUS ROUTE.  THESE EFFECTS ARE NOT
    EXPECTED TO BE OBSERVED IN THE OCCUPATIONAL SETTING.

=====================  Ecological Information  =====================

Ecological:ECOLOGICAL PROPERTIES ARE BASED ON STUDIES WITH THE ACTIVE
    INGREDIENT, GADODIAMIDE.  MICROBIAL GROWTH INHIBITION:>1000 MG/L;
    AEROBIC BIODEGRADATION: 121 HRS; PHOTODEGRADATION: NOT EXPECTED TO
    PHOTODEG RADE; ACUTE AQUATIC TOXICITY:>1000 MG/L. WASTEWATER
    TREATMENT EFFECTS: NO NEGATIVE IMPACT PROJECTED ON WASTEWATER
    PRETREATMENT, BIOTREATMENT, OR ELEMENTARY NEUTRALIZATION FACILITIES
    DURING NORMAL OPER ATION.

====================  Disposal Considerations  ====================

Waste Disposal Methods:DISCHARGE, TREATMENT, OR DISPOSAL ARE SUBJECT TO
    FEDERAL, STATE, AND/OR LOCAL LAWS.	PACK WASTE PRODUCT INTO
    SUITABLE CONTAINER	WITH ABSORBENT MATERIAL.  COLLECT THE SUBSTANCE
    IN IMPERVIOUS WASTE CON TAINERS.  SEAL AND LABEL THE WASTE
    CONTAINER APPROPRIATELY FOR SAFE HANDLING AND DISPOSAL.  BURN IN 
    CHEMICAL INCINERATOR WITH CONTROL DEVICES.

===================  MSDS Transport Information  ===================

Transport Information:NOT RESTRICTED.

=======================  Other Information  =======================

 Disclaimer (provided with this information by the compiling agencies):
 This information is formulated for use by elements of the Department
 of Defense.  The United States of America in no manner whatsoever,
 expressly or implied, warrants this information to be accurate and
 disclaims all liability for its use.  Any person utilizing this
 document should seek competent professional advice to verify and
 assume responsibility for the suitability of this information to their
 particular situation.