ROCHE DERMATOLOGICS DIV OF HOFFMANN-LA ROCHE INC -- FLUMAZENIL -- 6850-00F049005
===================== Product Identification =====================
Product ID:FLUMAZENIL
MSDS Date:06/01/1994
FSC:6850
NIIN:00F049005
MSDS Number: BZVFT
=== Responsible Party ===
Company Name:ROCHE DERMATOLOGICS DIV OF HOFFMANN-LA ROCHE INC
Address:340 KINGSLAND STREET
City:NUTLEY
State:NJ
ZIP:07110-1199
Country:US
Info Phone Num:800-526-6367
Emergency Phone Num:201-235-6660
Preparer's Name:HESHAM M SOLIMAN
CAGE:GO581
=== Contractor Identification ===
Company Name:ROCHE DERMATOLOGICS DIV OF HOFFMANN-LA ROCHE INC
Address:340 KINGSLAND STREET
City:NUTLEY
State:NJ
ZIP:07110-1199
Country:US
Phone:800-526-6367
CAGE:GO581
============= Composition/Information on Ingredients =============
Ingred Name:FLUMAZENIL *96-2*
CAS:78755-81-4
RTECS #:NI2922170
Fraction by Wt: >98%
===================== Hazards Identification =====================
LD50 LC50 Mixture:ORAL LD50(RAT): 4200 MG/KG
Routes of Entry: Inhalation:YES Skin:NO Ingestion:YES
Reports of Carcinogenicity:NTP:NO IARC:NO OSHA:NO
Health Hazards Acute and Chronic:MAY CAUSE CENTRAL NERVOUS SYSTEM &
CARDIOVASCULAR EFFECTS. MATERIAL MAY AFFECT THE DEVELOPING FETUS,
FEMALES PLANNING TO HAVE CHILDREN & PREGNANT WOMEN, NURSING MOTHERS
SHOULD USE CAUTION REGARDING EX POSURE.
Explanation of Carcinogenicity:NONE
Effects of Overexposure:MATERIAL MAY AFFECT THE DEVELOPING FETUS,
FEMALES PLANNING TO HAVE CHILDREN, PREGNANT WOMEN & NURSING MOTHERS
SHOULD USE CAUTION REGARDING EXPOSURE.
======================= First Aid Measures =======================
First Aid:INHALATION: REMOVE TO FRESH AIR. GIVE CPR/OXYGEN IF NEEDED.
SKIN: WASH W/SOAP & PLENTY OF WATER. EYES: FLUSH W/PLENTY OF WATER.
INGESTION: DON'T INDUCE VOMITING, UNLESS DIRECTED BY MEDICAL
PERSONNEL. NEVER GIVE ANYTHING BY MOUTH TO AN UNCONSCIOUS PERSON.
OBTAIN MEDICAL ATTENTION IN ALL CASES.
===================== Fire Fighting Measures =====================
Extinguishing Media:WATER, CO2, DRY CHEMICAL, FOAM.
Fire Fighting Procedures:WEAR NIOSH/MSHA APPROVED POSITIVE PRESSURE,
SCBA & FULL PROTECTIVE TURN OUT GEAR. USE WATER TO COOL CONTAINERS.
Unusual Fire/Explosion Hazard:SEVERE DUST EXPLOSION HAZARD. TOXIC &
CORROSIVE EMISSIONS MAY BE GIVEN OFF IN A FIRE.
================== Accidental Release Measures ==================
Spill Release Procedures:SHUT OFF IGNITION SOURCES SAFELY. SCOOP/SHOVEL
MATERIAL INTO A SUITABLE LABELED OPEN HEAD DRUM. SECURE THE DRUM
COVER & MOVE THE CONTAINER TO A SAFE HOLDING AREA. MOP/FLUSH THE
AREA.
====================== Handling and Storage ======================
Handling and Storage Precautions:STORE AT 59-86F. DON'T HEAT >320F,
GENERATE DUST/EXPOSE TO IGNITION SOURCES. GROUND & BOND TRANSFER
EQUIPMENT. AVOID IGNITION SOURCES.
Other Precautions:MILLING/MIXING/DRYING, PERFORM IN DEVICES EQUIPPED
W/EXPLOSION RELIEF/SUPPRESSION SYSTEMS/UNDER INERT CONDITIONS.
AVOID CONTACT W/EYES, SKIN & CLOTHING, BREATHING DUST. USE ADEQUATE
VENTILATION. STORE IN COOL, DRY AREA.
============= Exposure Controls/Personal Protection =============
Respiratory Protection:NEGATIVE PRESSURE AIR PURIFYING, HALF FACE,
TOXIC DUST/MIST/FUME HIGH EFFICIENCY FILTER.
Ventilation:LOCAL VENTILATION. USE IN A LAB HOOD.
Protective Gloves:LATEX, PLASTIC/RUBBER
Eye Protection:SAFETY GLASSES/GOGGLES
Work Hygienic Practices:REMOVE/LAUNDER CONTAMINATED CLOTHING & SHOES
BEFORE REUSE.
Supplemental Safety and Health
HANDLING & STORAGE CONT'D: KEEP CONTAINER TIGHTLY CLOSED WHEN NOT IN
USE.
================== Physical/Chemical Properties ==================
Melt/Freeze Pt:M.P/F.P Text:388-395.6F
Appearance and Odor:WHITE TO OFF-WHITE POWDER W/NO ODOR.
================= Stability and Reactivity Data =================
Stability Indicator/Materials to Avoid:YES
Stability Condition to Avoid:ELEVATED TEMP, WATER, DUST ACCUMULATION,
AIRBORNE DUST, IGNITION SOURCES, TEMP >212F.
Hazardous Decomposition Products:CO, CO2, OXIDES OF NITROGEN, HYDROGEN
FLUORIDE.
==================== Disposal Considerations ====================
Waste Disposal Methods:PRODUCT IS SUITABLE FOR INCINERATION. USE,
PROCESSING, ALTERATION/CONTAMINATION MAY AFFECT DISPOSAL
RECOMMENDATIONS. DISPOSE OF IAW/FEDERAL, STATE & LOCAL REGULATIONS.
Disclaimer (provided with this information by the compiling agencies):
This information is formulated for use by elements of the Department
of Defense. The United States of America in no manner whatsoever,
expressly or implied, warrants this information to be accurate and
disclaims all liability for its use. Any person utilizing this
document should seek competent professional advice to verify and
assume responsibility for the suitability of this information to their
particular situation.