Flumazenil

ROCHE DERMATOLOGICS DIV OF HOFFMANN-LA ROCHE INC -- FLUMAZENIL -- 6850-00F049005
=====================  Product Identification  =====================

Product ID:FLUMAZENIL
MSDS Date:06/01/1994
FSC:6850
NIIN:00F049005
MSDS Number: BZVFT
=== Responsible Party ===
Company Name:ROCHE DERMATOLOGICS DIV OF HOFFMANN-LA ROCHE INC
Address:340 KINGSLAND STREET
City:NUTLEY
State:NJ
ZIP:07110-1199
Country:US
Info Phone Num:800-526-6367
Emergency Phone Num:201-235-6660
Preparer's Name:HESHAM M SOLIMAN
CAGE:GO581
=== Contractor Identification ===
Company Name:ROCHE DERMATOLOGICS DIV OF HOFFMANN-LA ROCHE INC
Address:340 KINGSLAND STREET
City:NUTLEY
State:NJ
ZIP:07110-1199
Country:US
Phone:800-526-6367
CAGE:GO581

=============  Composition/Information on Ingredients  =============

Ingred Name:FLUMAZENIL *96-2*
CAS:78755-81-4
RTECS #:NI2922170
Fraction by Wt: >98%

=====================  Hazards Identification  =====================

LD50 LC50 Mixture:ORAL LD50(RAT): 4200 MG/KG
Routes of Entry: Inhalation:YES  Skin:NO  Ingestion:YES
Reports of Carcinogenicity:NTP:NO    IARC:NO	OSHA:NO
Health Hazards Acute and Chronic:MAY CAUSE CENTRAL NERVOUS SYSTEM &
    CARDIOVASCULAR EFFECTS. MATERIAL MAY AFFECT THE DEVELOPING FETUS,
    FEMALES PLANNING TO HAVE CHILDREN & PREGNANT WOMEN, NURSING MOTHERS
    SHOULD USE CAUTION REGARDING EX POSURE.
Explanation of Carcinogenicity:NONE
Effects of Overexposure:MATERIAL MAY AFFECT THE DEVELOPING FETUS,
    FEMALES PLANNING TO HAVE CHILDREN, PREGNANT WOMEN & NURSING MOTHERS
    SHOULD USE CAUTION REGARDING EXPOSURE.

=======================  First Aid Measures  =======================

First Aid:INHALATION: REMOVE TO FRESH AIR. GIVE CPR/OXYGEN IF NEEDED.
    SKIN: WASH W/SOAP & PLENTY OF WATER. EYES: FLUSH W/PLENTY OF WATER.
    INGESTION: DON'T INDUCE VOMITING, UNLESS DIRECTED BY MEDICAL
    PERSONNEL.	NEVER GIVE ANYTHING BY MOUTH TO AN UNCONSCIOUS PERSON.
    OBTAIN MEDICAL ATTENTION IN ALL CASES.

=====================  Fire Fighting Measures  =====================

Extinguishing Media:WATER, CO2, DRY CHEMICAL, FOAM.
Fire Fighting Procedures:WEAR NIOSH/MSHA APPROVED POSITIVE PRESSURE,
    SCBA & FULL PROTECTIVE TURN OUT GEAR. USE WATER TO COOL CONTAINERS.
Unusual Fire/Explosion Hazard:SEVERE DUST EXPLOSION HAZARD. TOXIC &
    CORROSIVE EMISSIONS MAY BE GIVEN OFF IN A FIRE.

==================  Accidental Release Measures  ==================

Spill Release Procedures:SHUT OFF IGNITION SOURCES SAFELY. SCOOP/SHOVEL
    MATERIAL INTO A SUITABLE LABELED OPEN HEAD DRUM. SECURE THE DRUM
    COVER & MOVE THE CONTAINER TO A SAFE HOLDING AREA. MOP/FLUSH THE
    AREA.

======================	Handling and Storage  ======================

Handling and Storage Precautions:STORE AT 59-86F. DON'T HEAT >320F,
    GENERATE DUST/EXPOSE TO IGNITION SOURCES. GROUND & BOND TRANSFER
    EQUIPMENT. AVOID IGNITION SOURCES.
Other Precautions:MILLING/MIXING/DRYING, PERFORM IN DEVICES EQUIPPED
    W/EXPLOSION RELIEF/SUPPRESSION SYSTEMS/UNDER INERT CONDITIONS.
    AVOID CONTACT W/EYES, SKIN & CLOTHING, BREATHING DUST. USE ADEQUATE
    VENTILATION. STORE	IN COOL, DRY AREA.

=============  Exposure Controls/Personal Protection  =============

Respiratory Protection:NEGATIVE PRESSURE AIR PURIFYING, HALF FACE,
    TOXIC DUST/MIST/FUME HIGH EFFICIENCY FILTER.
Ventilation:LOCAL VENTILATION. USE IN A LAB HOOD.
Protective Gloves:LATEX, PLASTIC/RUBBER
Eye Protection:SAFETY GLASSES/GOGGLES
Work Hygienic Practices:REMOVE/LAUNDER CONTAMINATED CLOTHING & SHOES
    BEFORE REUSE.
Supplemental Safety and Health
HANDLING & STORAGE CONT'D: KEEP CONTAINER TIGHTLY CLOSED WHEN NOT IN
    USE.

==================  Physical/Chemical Properties  ==================

Melt/Freeze Pt:M.P/F.P Text:388-395.6F
Appearance and Odor:WHITE TO OFF-WHITE POWDER W/NO ODOR.

=================  Stability and Reactivity Data  =================

Stability Indicator/Materials to Avoid:YES
Stability Condition to Avoid:ELEVATED TEMP, WATER, DUST ACCUMULATION,
    AIRBORNE DUST, IGNITION SOURCES, TEMP >212F.
Hazardous Decomposition Products:CO, CO2, OXIDES OF NITROGEN, HYDROGEN
    FLUORIDE.

====================  Disposal Considerations  ====================

Waste Disposal Methods:PRODUCT IS SUITABLE FOR INCINERATION. USE,
    PROCESSING, ALTERATION/CONTAMINATION MAY AFFECT DISPOSAL
    RECOMMENDATIONS. DISPOSE OF IAW/FEDERAL, STATE & LOCAL REGULATIONS.

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