Euufillin

Material Safety Data Sheet
Aminophylline, 99% (combined mixture of theophylline and ethylenediamine)

ACC# 98819

Section 1 - Chemical Product and Company Identification

MSDS Name: Aminophylline, 99% (combined mixture of theophylline and ethylenediamine)
Catalog Numbers: AC202560000, AC202561000
Synonyms: Theophylline, compound with ethylenediamine (2 to 1) dihydrate; 1H-Purine-2,6-dione, 3,7-dihydro-1,3-dimethyl-, compd. with 1,2-ethanediamine (2:1); 3,7-Dihydro-1,3-dimethyl-1H-purine-2,6-dione compd. with 1,2-ethanediamine (2:1); Theophylline ethylenediamine
Company Identification:
Acros Organics N.V.
One Reagent Lane
Fair Lawn, NJ 07410
For information in North America, call: 800-ACROS-01
For emergencies in the US, call CHEMTREC: 800-424-9300

Section 2 - Composition, Information on Ingredients

CAS#	Chemical Name	Percent	EINECS/ELINCS
317-34-0	Aminophylline	99	206-264-5

Section 3 - Hazards Identification

EMERGENCY OVERVIEW

Appearance: white to pale yellow powder.
Warning! Toxic. Harmful if swallowed. Causes gastrointestinal and central nervous system effects. Air sensitive. May cause cardiac disturbances.
Target Organs: Kidneys, heart, central nervous system, lungs.

Potential Health Effects
Eye: May cause eye irritation.
Skin: May cause irritation and dermatitis.
Ingestion: Harmful if swallowed. Ingestion of large amounts may cause systemic effects such as nausea, stomach pain, rapid breathing, sweating, convulsions, coma, cardiovascular collapse and possible death. May cause nausea, vomiting, and diarrhea, possibly with blood. May cause wakefulness and restlessness, irritability, excitement, rapid heart rate, ringing in the ears, anorexia, muscle spasms and convulsions, gastrointestinal irritation, headache, dizziness, seizures, dehydration and fever.
Inhalation: May cause effects similar to those described for ingestion.
Chronic: No information found.

Section 4 - First Aid Measures

Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid imme diately.
Skin: Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Ingestion: Never give anything by mouth to an unconscious person. Get medical aid immediately. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
Inhalation: Get medical aid immediately. Remove from exposure and move to fresh air immediately. If breathing is difficult, give oxygen. Do not use mouth-to-mouth resuscitation if victim ingested or inhaled the substance; induce artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device.
Notes to Physician: Treat symptomatically and supportively.

Section 5 - Fire Fighting Measures

General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion.
Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or appropriate foam.
Flash Point: Not applicable.
Autoignition Temperature: Not applicable.
Explosion Limits, Lower:Not available.
Upper: Not available.
NFPA Rating: (estimated) Health: 2; Flammability: 0; Instability: 1

Section 6 - Accidental Release Measures

General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks: Sweep up, then place into a suitable container for disposal. Avoid generating dusty conditions. Provide ventilation.

Section 7 - Handling and Storage

Handling: Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Do not get in eyes, on skin, or on clothing. Keep container tightly closed. Do not ingest or inhale. Store protected from air. Use and store under nitrogen. Use only in a chemical fume hood. Do not breathe dust.
Storage: Store in a cool, dry, well-ventilated area away from incompatible substances. Keep containers tightly closed. Store in air tight containers.

Section 8 - Exposure Controls, Personal Protection

Engineering Controls: Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate general or local exhaust ventilation to keep airborne concentrations below the permissible exposure limits.
Exposure Limits

Chemical Name	ACGIH	NIOSH	OSHA - Final PELs
Aminophylline	none listed	none listed	none listed

OSHA Vacated PELs: Aminophylline: No OSHA Vacated PELs are listed for this chemical.
Personal Protective Equipment
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin: Wear appropriate protective gloves and clothing to prevent skin exposure.
Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators: A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant respirator use.

Section 9 - Physical and Chemical Properties

Physical State: Powder
Appearance: white to pale yellow
Odor: ammonia-like
pH: Not available.
Vapor Pressure: Not available.
Vapor Density: Not available.
Evaporation Rate:Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point:269.00 - 270.00 deg C
Decomposition Temperature:Not available.
Solubility: 1g/5 mL water
Specific Gravity/Density:Not available.
Molecular Formula:C16H24N10O4.2H2O
Molecular Weight:456.45

Section 10 - Stability and Reactivity

Chemical Stability: Stable under normal temperatures and pressures. Absorbs carbon dioxide from the air. Unstable in acid solution.
Conditions to Avoid: Incompatible materials, exposure to air, acids, strong oxidants.
Incompatibilities with Other Materials: Strong oxidizing agents, acids, air.
Hazardous Decomposition Products: Nitrogen oxides, carbon monoxide, carbon dioxide.
Hazardous Polymerization: Has not been reported.

Section 11 - Toxicological Information

RTECS#:
CAS# 317-34-0: XH5600000
LD50/LC50:
CAS# 317-34-0:
     Oral, mouse: LD50 = 150 mg/kg;
     Oral, rat: LD50 = 243 mg/kg;
.

Carcinogenicity:
CAS# 317-34-0: Not listed by ACGIH, IARC, NTP, or CA Prop 65.

Epidemiology: No data available.
Teratogenicity: No data available.
Reproductive Effects: No data available.
Mutagenicity: No data available.
Neurotoxicity: No data available.
Other Studies:

Section 12 - Ecological Information

Ecotoxicity: No data available. No information available.
Environmental: No data available.
Physical: No data available.
Other: None.

Section 13 - Disposal Considerations

Chemical waste generators must determine whether a discarded chemical is classified as a hazardous waste. US EPA guidelines for the classification determination are listed in 40 CFR Parts 261.3. Additionally, waste generators must consult state and local hazardous waste regulations to ensure complete and accurate classification.
RCRA P-Series: None listed.
RCRA U-Series: None listed.

Section 14 - Transport Information

	US DOT	Canada TDG
Shipping Name:	Not regulated as a hazardous material	No information available.
Hazard Class:
UN Number:
Packing Group:

Section 15 - Regulatory Information

US FEDERAL

TSCA
     CAS# 317-34-0 is listed on the TSCA inventory.
Health & Safety Reporting List
     None of the chemicals are on the Health & Safety Reporting List.
Chemical Test Rules
     None of the chemicals in this product are under a Chemical Test Rule.
Section 12b
     None of the chemicals are listed under TSCA Section 12b.
TSCA Significant New Use Rule
     None of the chemicals in this material have a SNUR under TSCA.
CERCLA Hazardous Substances and corresponding RQs
     None of the chemicals in this material have an RQ.
SARA Section 302 Extremely Hazardous Substances
     None of the chemicals in this product have a TPQ.
Section 313      No chemicals are reportable under Section 313.
Clean Air Act:
     This material does not contain any hazardous air pollutants.
     This material does not contain any Class 1 Ozone depletors.
     This material does not contain any Class 2 Ozone depletors.
Clean Water Act:
     None of the chemicals in this product are listed as Hazardous Substances under the CWA.
     None of the chemicals in this product are listed as Priority Pollutants under the CWA.
     None of the chemicals in this product are listed as Toxic Pollutants under the CWA.
OSHA:
     None of the chemicals in this product are considered highly hazardous by OSHA.
STATE
     CAS# 317-34-0 is not present on state lists from CA, PA, MN, MA, FL, or NJ.

California Prop 65

California No Significant Risk Level: None of the chemicals in this product are listed.

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols:
     XN
Risk Phrases:
     R 22 Harmful if swallowed.

Safety Phrases:
     S 22 Do not breathe dust.
     S 24/25 Avoid contact with skin and eyes.

WGK (Water Danger/Protection)
     CAS# 317-34-0: No information available.
Canada - DSL/NDSL
     CAS# 317-34-0 is listed on Canada's NDSL List.
Canada - WHMIS
     This product has a WHMIS classification of D1B, D2B.
This product has been classified in accordance with the hazard criteria of the Controlled Products Regulations and the MSDS contains all of the information required by those regulations.
Canadian Ingredient Disclosure List

Section 16 - Additional Information

MSDS Creation Date: 9/02/1997
Revision #6 Date: 10/03/2005

The information above is believed to be accurate and represents the best information currently available to us. However, we make no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assume no liability resulting from its use. Users should make their own investigations to determine the suitability of the information for their particular purposes. In no event shall Fisher be liable for any claims, losses, or damages of any third party or for lost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if Fisher has been advised of the possibility of such damages.