UNITED STATES PHARMACOPEIAL CONVENTION INC -- DOXEPIN HYDROCHLORIDE -- 6505-00F036921
===================== Product Identification =====================
Product ID:DOXEPIN HYDROCHLORIDE
MSDS Date:03/29/1989
FSC:6505
NIIN:00F036921
MSDS Number: BVSQZ
=== Responsible Party ===
Company Name:UNITED STATES PHARMACOPEIAL CONVENTION INC
Address:12601 TWINBROOK PKWY
City:ROCKVILLE
State:MD
ZIP:20852-1717
Country:US
Info Phone Num:301-881-0666
Emergency Phone Num:301-881-0666
Preparer's Name:JEROME A HALPERIN
CAGE:14128
=== Contractor Identification ===
Company Name:UNITED STATES PHARMACOPEIAL CONVENTION INC
Address:12601 TWINBROOK PKWY
Box:City:ROCKVILLE
State:MD
ZIP:20852-1717
Country:US
Phone:301-881-0666
CAGE:14128
============= Composition/Information on Ingredients =============
Ingred Name:DOXEPIN HYDROCHLORIDE *94-3*
CAS:1229-29-4
RTECS #:HQ4375000
Fraction by Wt: 100%
===================== Hazards Identification =====================
LD50 LC50 Mixture:ORAL LD50 (RAT): 147 MG/KG
Routes of Entry: Inhalation:YES Skin:YES Ingestion:YES
Reports of Carcinogenicity:NTP:NO IARC:NO OSHA:NO
Health Hazards Acute and
Chronic:ARRHYTHMIA/TACHYCARDIA/DYSPENA/PARESTHESIA/RESPRIATORY
DEPRESSION/CYANOSIS. POSSIBLE ALLERGIC REACTION TO DUST IF
INHALED/INGESTED/CONTACT W/SKIN. EYE/SKIN/RESPIRATORY TRACT
IRRITATION. POSSIBLE HYPER SENSITIZATION. IRRITATING TO MUCOUS
MEMBRANES/RESPIRATORY TRACT. (SEE SUPP)
Explanation of Carcinogenicity:NONE
Effects of
Overexposure:IRRITATION/DROWSINESS/DIZZINESS/HEADACHE/EUPHORIA/STUP
OR/RESTLESSNESS/AGITATION/INSOMNIA/SLEEP/SOMNOLENCE/CONVULSIONS/MUS
CLE CONTRACTIONS/SPASTICITY/COMA/BLOOD PRESSURE
DECREASE/SHOCK/VOMITING/DILATED PUPILS/BLURRED VISION/DRY
MOUTH/CONSTIPATION/KIDNEY CHANGES/URINARY RETENTION/DISTURBED
CONCENTRATION/(SEE SUPP)
Medical Cond Aggravated by Exposure:HYPERSENSITIVITY TO MATERIAL,
PRE-EXISTING HEART DISEASE, NARROW ANGLE GLAUCOMA, LIVER/KIDNEY
IMPAIRMENT.
======================= First Aid Measures =======================
First Aid:INHALATION: REMOVE TO FRESH AIR. EYES/SKIN: FLUSH W/WATER.
INGESTION: FLUSH OUT MOUTH W/WATER. MAINTAIN RESPIRATORY FUNCTION.
TREATMENT OF OVERDOSE IS SYMPTOMATIC/SUPPORTIVE. EMPTY STOMACH BY
GASTRIC LAVAGE. ADMINISTER ACTIVATE CHARCOAL SLURRY REPEATEDLY
FOLLOWED BY STIMULANT CATHARTIC. MAINTAIN BODY TEMP. MONITOR
CARDIOVASCULAR FUNCTION FOR 5 DAYS. CONTROL CARDIAC ARRHYTHMIAS
W/LIDOCAINE. (SUPP)
===================== Fire Fighting Measures =====================
Extinguishing Media:WATER SPRAY, DRY CHEMICAL, CO2, FOAM AS APPROPRIATE
FOR SURROUNDING FIRE/MATERIALS.
Fire Fighting Procedures:EVACUATE AREA. WEAR SELF CONTAINED BREATHING
APPARATUS & PROTECTIVE CLOTHING.
Unusual Fire/Explosion Hazard:MATERIAL IS ASSUMED TO BE COMBUSTIBLE. AS
W/ALL DRY POWDERS IT'S ADVISABLE TO GROUND MECHANICAL EQUIPMENT IN
CONTACT W/DRY MATERIAL TO DISSIPATE STATIC.
================== Accidental Release Measures ==================
Spill Release Procedures:WEAR APPROVED RESPIRATOR & CHEMICALLY
COMPATIBLE GLOVES. VACUUM/SWEEP UP. AVOID DUST. PLACE MATERIAL IN
APPROPRIATE CONTAINER FOR WASTE DISPOSAL. VENTILATE AREA & WASH
SITE.
====================== Handling and Storage ======================
Handling and Storage Precautions:STORE IN TIGHT CONTAINER. SHOULD BE
HANDLED/STORED PER LABEL/OTHER INSTRUCTIONS TO ENSURE PRODUCT
INTEGRITY. USE W/ADEQUATE VENTILATION.
Other Precautions:AVOID CONTACT W/EYES, SKIN/CLOTHING. AVOID BREATHING
DUST/MIST/FUMES/VAPORS. USE W/ADEAUATE DUST CONROL. DON'T PERMIT
EATING/DRINKING/SMOKING NEAR MATERIAL.
============= Exposure Controls/Personal Protection =============
Respiratory Protection:WEAR NIOSH APPROVED RESPIRATOR.
Ventilation:ADEQUATE. LOCAL EXHAUST/MECHANICAL (GENERAL): RECOMMENDED.
Protective Gloves:NEOPRENE, RUBBER
Eye Protection:SAFETY GOGGLES
Other Protective Equipment:APPROPRIATE LABORATORY APPAREL
Work Hygienic Practices:REMOVE/LAUNDER CONTAMINATED CLOTHING BEFORE
REUSE. WASH THOROUGHLY AFTER HANDLING.
Supplemental Safety and Health
SYMPTOMS CONT'D: DISORIENTATION/EXCITEMENT/TINGLING OF
EXTREMITIES/PHOTOSENSITIZATION/EDEMA OF
FACE/TONGUE/FEVER/HALLUCINATION. FIRST AID CONT'D: ADMINISTER 1-3MG
PHYSOSTIGMINE SALICYLATE FOR ADULTS B Y FLOW INTRAVENOUS INFUSION
OVER 2-3 MINS. ADMINISTER ANTICONVULSANTS. STANDARD MEASURES FOR
SHOCK/METABOLIC ACIDOSIS.
================== Physical/Chemical Properties ==================
Solubility in Water:COMPLETE
Appearance and Odor:WHITE CRYSTALLINE POWDER W/SLIGHT AMINE LIKE ODOR
================= Stability and Reactivity Data =================
Stability Indicator/Materials to Avoid:YES
OXIDIZING AGENTS
Stability Condition to Avoid:HEAT
Hazardous Decomposition Products:TOXIC FUMES, NITROGEN OXIDES, HYDROGEN
CHLORIDE
==================== Disposal Considerations ====================
Waste Disposal Methods:DISPOSE OF IAW/FEDERAL, STATE & LOCAL
REGULATIONS.
Disclaimer (provided with this information by the compiling agencies):
This information is formulated for use by elements of the Department
of Defense. The United States of America in no manner whatsoever,
expressly or implied, warrants this information to be accurate and
disclaims all liability for its use. Any person utilizing this
document should seek competent professional advice to verify and
assume responsibility for the suitability of this information to their
particular situation.