Doxepinum [Inn-Latin]

UNITED STATES PHARMACOPEIAL CONVENTION INC -- DOXEPIN HYDROCHLORIDE -- 6505-00F036921
=====================  Product Identification  =====================

Product ID:DOXEPIN HYDROCHLORIDE
MSDS Date:03/29/1989
FSC:6505
NIIN:00F036921
MSDS Number: BVSQZ
=== Responsible Party ===
Company Name:UNITED STATES PHARMACOPEIAL CONVENTION INC
Address:12601 TWINBROOK PKWY
City:ROCKVILLE
State:MD
ZIP:20852-1717
Country:US
Info Phone Num:301-881-0666
Emergency Phone Num:301-881-0666
Preparer's Name:JEROME A HALPERIN
CAGE:14128
=== Contractor Identification ===
Company Name:UNITED STATES PHARMACOPEIAL CONVENTION INC
Address:12601 TWINBROOK PKWY
Box:City:ROCKVILLE
State:MD
ZIP:20852-1717
Country:US
Phone:301-881-0666
CAGE:14128

=============  Composition/Information on Ingredients  =============

Ingred Name:DOXEPIN HYDROCHLORIDE      *94-3*
CAS:1229-29-4
RTECS #:HQ4375000
Fraction by Wt: 100%

=====================  Hazards Identification  =====================

LD50 LC50 Mixture:ORAL LD50 (RAT): 147 MG/KG
Routes of Entry: Inhalation:YES  Skin:YES  Ingestion:YES
Reports of Carcinogenicity:NTP:NO    IARC:NO	OSHA:NO
Health Hazards Acute and
    Chronic:ARRHYTHMIA/TACHYCARDIA/DYSPENA/PARESTHESIA/RESPRIATORY
    DEPRESSION/CYANOSIS. POSSIBLE ALLERGIC REACTION TO DUST IF
    INHALED/INGESTED/CONTACT W/SKIN. EYE/SKIN/RESPIRATORY TRACT
    IRRITATION. POSSIBLE HYPER SENSITIZATION. IRRITATING TO MUCOUS
    MEMBRANES/RESPIRATORY TRACT.  (SEE SUPP)
Explanation of Carcinogenicity:NONE
Effects of
    Overexposure:IRRITATION/DROWSINESS/DIZZINESS/HEADACHE/EUPHORIA/STUP
    OR/RESTLESSNESS/AGITATION/INSOMNIA/SLEEP/SOMNOLENCE/CONVULSIONS/MUS
    CLE CONTRACTIONS/SPASTICITY/COMA/BLOOD PRESSURE
    DECREASE/SHOCK/VOMITING/DILATED  PUPILS/BLURRED VISION/DRY
    MOUTH/CONSTIPATION/KIDNEY CHANGES/URINARY RETENTION/DISTURBED
    CONCENTRATION/(SEE SUPP)
Medical Cond Aggravated by Exposure:HYPERSENSITIVITY TO MATERIAL,
    PRE-EXISTING HEART DISEASE, NARROW ANGLE GLAUCOMA, LIVER/KIDNEY
    IMPAIRMENT.

=======================  First Aid Measures  =======================

First Aid:INHALATION: REMOVE TO FRESH AIR. EYES/SKIN: FLUSH W/WATER.
    INGESTION: FLUSH OUT MOUTH W/WATER. MAINTAIN RESPIRATORY FUNCTION.
    TREATMENT OF OVERDOSE IS SYMPTOMATIC/SUPPORTIVE. EMPTY STOMACH BY
    GASTRIC  LAVAGE. ADMINISTER ACTIVATE CHARCOAL SLURRY REPEATEDLY
    FOLLOWED BY STIMULANT CATHARTIC. MAINTAIN BODY TEMP. MONITOR
    CARDIOVASCULAR FUNCTION FOR 5 DAYS. CONTROL CARDIAC ARRHYTHMIAS
    W/LIDOCAINE. (SUPP)

=====================  Fire Fighting Measures  =====================

Extinguishing Media:WATER SPRAY, DRY CHEMICAL, CO2, FOAM AS APPROPRIATE
    FOR SURROUNDING FIRE/MATERIALS.
Fire Fighting Procedures:EVACUATE AREA. WEAR SELF CONTAINED BREATHING
    APPARATUS & PROTECTIVE CLOTHING.
Unusual Fire/Explosion Hazard:MATERIAL IS ASSUMED TO BE COMBUSTIBLE. AS
    W/ALL DRY POWDERS IT'S ADVISABLE TO GROUND MECHANICAL EQUIPMENT IN
    CONTACT W/DRY MATERIAL TO DISSIPATE STATIC.

==================  Accidental Release Measures  ==================

Spill Release Procedures:WEAR APPROVED RESPIRATOR & CHEMICALLY
    COMPATIBLE GLOVES. VACUUM/SWEEP UP. AVOID DUST. PLACE MATERIAL IN
    APPROPRIATE CONTAINER FOR WASTE DISPOSAL. VENTILATE AREA & WASH
    SITE.

======================	Handling and Storage  ======================

Handling and Storage Precautions:STORE IN TIGHT CONTAINER. SHOULD BE
    HANDLED/STORED PER LABEL/OTHER INSTRUCTIONS TO ENSURE PRODUCT
    INTEGRITY. USE W/ADEQUATE VENTILATION.
Other Precautions:AVOID CONTACT W/EYES, SKIN/CLOTHING. AVOID BREATHING
    DUST/MIST/FUMES/VAPORS. USE W/ADEAUATE DUST CONROL. DON'T PERMIT
    EATING/DRINKING/SMOKING NEAR MATERIAL.

=============  Exposure Controls/Personal Protection  =============

Respiratory Protection:WEAR NIOSH APPROVED RESPIRATOR.
Ventilation:ADEQUATE. LOCAL EXHAUST/MECHANICAL (GENERAL): RECOMMENDED.
Protective Gloves:NEOPRENE, RUBBER
Eye Protection:SAFETY GOGGLES
Other Protective Equipment:APPROPRIATE LABORATORY APPAREL
Work Hygienic Practices:REMOVE/LAUNDER CONTAMINATED CLOTHING BEFORE
    REUSE. WASH THOROUGHLY AFTER HANDLING.
Supplemental Safety and Health
SYMPTOMS CONT'D: DISORIENTATION/EXCITEMENT/TINGLING OF
    EXTREMITIES/PHOTOSENSITIZATION/EDEMA OF
    FACE/TONGUE/FEVER/HALLUCINATION. FIRST AID CONT'D: ADMINISTER 1-3MG
    PHYSOSTIGMINE SALICYLATE FOR ADULTS B Y FLOW INTRAVENOUS INFUSION
    OVER 2-3 MINS. ADMINISTER ANTICONVULSANTS. STANDARD MEASURES FOR
    SHOCK/METABOLIC ACIDOSIS.

==================  Physical/Chemical Properties  ==================

Solubility in Water:COMPLETE
Appearance and Odor:WHITE CRYSTALLINE POWDER W/SLIGHT AMINE LIKE ODOR

=================  Stability and Reactivity Data  =================

Stability Indicator/Materials to Avoid:YES
OXIDIZING AGENTS
Stability Condition to Avoid:HEAT
Hazardous Decomposition Products:TOXIC FUMES, NITROGEN OXIDES, HYDROGEN
    CHLORIDE

====================  Disposal Considerations  ====================

Waste Disposal Methods:DISPOSE OF IAW/FEDERAL, STATE & LOCAL
    REGULATIONS.

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