Dinoprostone Prostaglandin E2

MSDS Language: EN
Country:
                      **** MATERIAL SAFETY DATA SHEET ****

  Prostaglandin E2, 98%

        **** SECTION 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION ****

MSDS Name: Prostaglandin E2, 98%
Catalog Numbers:
     23356-0000, 23356-0100
Synonyms:
     PGE2, (5Z,11�1,13E,15S)-11,15-Dihydroxy-9-oxoprosta-5,13-dien-1-oic
     acid, 7-[3-Hydroxy-2-(3-hydroxy-1-octenyl)-5-oxocyclopentyl]-5
Company Identification (Europe):  Acros Organics BVBA
                                  Janssen Pharmaceuticalaan 3a
                                  2440 Geel, Belgium
Company Identification (USA):     Acros Organics
                                  One Reagent Lane
                                  Fairlawn, NJ  07410
For information in North America, call:   800-ACROS-01
For information in Europe, call:          0032(0) 14575211
For emergencies in the US, call CHEMTREC: 800-424-9300
For emergencies in Europe, call:     0032(0) 14575299

          **** SECTION 2 - COMPOSITION, INFORMATION ON INGREDIENTS ****

+----------------+--------------------------------------+----------+-----------+-----------+---------------+
|      CAS#      |              Chemical Name           |    %     |  EINECS#  |Haz Symbols| Risk Phrases  |
|----------------|--------------------------------------|----------|-----------|-----------|---------------+
|      363-24-6  |Prostaglandin E2                      |    98    | 206-656-6 |||
+----------------+--------------------------------------+----------+-----------+-----------+---------------+
          Hazard Symbols: XN
          Risk Phrases: 22

                  **** SECTION 3 - HAZARDS IDENTIFICATION ****

                               EMERGENCY OVERVIEW
Harmful if swallowed.Light sensitive.

Potential Health Effects
     The toxicological properties of this material have not been
     investigated. Use appropriate procedures to prevent opportunities
     for direct contact with the skin or eyes and to prevent inhalation.

                    **** SECTION 4 - FIRST AID MEASURES ****

     Eyes:
          Immediately flush eyes with plenty of water for at least 15 minutes,
          occasionally lifting the upper and lower eyelids.
     Skin:
          Flush skin with plenty of water for at least 15 minutes while
          removing contaminated clothing and shoes.
     Ingestion:
          Do NOT induce vomiting. If conscious and alert, rinse mouth and
          drink 2-4 cupfuls of milk or water.
     Inhalation:
          Remove from exposure and move to fresh air immediately.
     Notes to Physician:

                  **** SECTION 5 - FIRE FIGHTING MEASURES ****

     General Information:
          As in any fire, wear a self-contained breathing apparatus in
          pressure-demand, MSHA/NIOSH (approved or equivalent), and full
          protective gear. During a fire, irritating and highly toxic gases
          may be generated by thermal decomposition or combustion.
     Extinguishing Media:
          In case of fire, use water, dry chemical, chemical foam, or
          alcohol-resistant foam.

                **** SECTION 6 - ACCIDENTAL RELEASE MEASURES ****

     General Information: Use proper personal protective equipment as indicated
                          in Section 8.
     Spills/Leaks:
          Clean up spills immediately, observing precautions in the Protective
          Equipment section. Sweep up, then place into a suitable container for
          disposal.

                   **** SECTION 7 - HANDLING and STORAGE ****

     Handling:
          Wash thoroughly after handling. Remove contaminated clothing and
          wash before reuse. Avoid contact with eyes, skin, and clothing. Avoid
          ingestion and inhalation.
     Storage:
          Store in a cool, dry place. Keep container closed when not in use.
          Deep freeze (below -20�C).

          **** SECTION 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION ****

     Engineering Controls:
          Use adequate general or local exhaust ventilation to keep airborne
          concentrations below the permissible exposure limits. Use process
          enclosure, local exhaust ventilation, or other engineering controls
          to control airborne levels.
     Personal Protective Equipment

                 Eyes:
                       Wear safety glasses and chemical goggles if splashing
                       is possible.
                 Skin:
                       Wear appropriate protective gloves and clothing to
                       prevent skin exposure.
             Clothing:
                       Wear appropriate protective clothing to minimize
                       contact with skin.
          Respirators:
                       Wear a NIOSH/MSHA or European Standard EN 149
                       approved full-facepiece airline respirator in the
                       positive pressure mode with emergency escape
                       provisions.

             **** SECTION 9 - PHYSICAL AND CHEMICAL PROPERTIES ****

Physical State:             Crystalline powder
Color:                      white
Odor:                       Not available.
pH:                         Not available.
Vapor Pressure:             Not available.
Viscosity:                  Not available.
Boiling Point:              Not available.
Freezing/Melting Point:     66.00 - 68.00 deg C
Autoignition Temperature:   Not available.
Flash Point:                Not available.
Explosion Limits, lower:    Not available.
Explosion Limits, upper:    Not available.
Decomposition Temperature:
Solubility in water:        Not available.
Specific Gravity/Density:
Molecular Formula:
Molecular Weight:           352.47

                 **** SECTION 10 - STABILITY AND REACTIVITY ****

     Chemical Stability:
          Stable under normal temperatures and pressures.
     Conditions to Avoid:
          Incompatible materials.
     Incompatibilities with Other Materials:
          Strong oxidizing agents, acids, bases.
     Hazardous Decomposition Products:
          Carbon monoxide, irritating and toxic fumes and gases, carbon
          dioxide.
     Hazardous Polymerization: Has not been reported.

                **** SECTION 11 - TOXICOLOGICAL INFORMATION ****

     RTECS#:
          CAS# 363-24-6: UK8000000
     LD50/LC50:
          CAS# 363-24-6: Oral, mouse: LD50 = 750 mg/kg; Oral, rat: LD50 = 500
          mg/kg.
     Carcinogenicity:
       Prostaglandin E2 -
          Not listed by ACGIH, IARC, NIOSH, NTP, or OSHA.
          See actual entry in RTECS for complete information.

                  **** SECTION 12 - ECOLOGICAL INFORMATION ****



                 **** SECTION 13 - DISPOSAL CONSIDERATIONS ****

Dispose of in a manner consistent with federal, state, and local regulations.

                  **** SECTION 14 - TRANSPORT INFORMATION ****

     IATA
          No information available.
     IMO
          No information available.
     RID/ADR
          No information available.

                  **** SECTION 15 - REGULATORY INFORMATION ****

 European/International Regulations
     European Labeling in Accordance with EC Directives
          Hazard Symbols: XN
          Risk Phrases:
                       R 22  Harmful if swallowed.
          Safety Phrases:
   WGK (Water Danger/Protection)
          CAS# 363-24-6: No information available.
   United Kingdom Occupational Exposure Limits

   United Kingdom Maximum Exposure Limits

   Canada
          None of the chemicals in this product are listed on the DSL/NDSL list.
          CAS# 363-24-6 is not listed on Canada's Ingredient Disclosure List.
   Exposure Limits
 US FEDERAL
     TSCA
          CAS# 363-24-6 is not listed on the TSCA inventory.
          It is for research and development use only.

                  **** SECTION 16 - ADDITIONAL INFORMATION ****

     MSDS Creation Date:  7/16/1996  Revision #0 Date: Original.

     The information above is believed to be accurate and represents the best
     information currently available to us. However, we make no warranty of
     merchantability or any other warranty, express or implied, with respect to
     such information, and we assume no liability resulting from its use. Users
     should make their own investigations to determine the suitability of the
     information for their particular purposes. In no way shall the company be
     liable for any claims, losses, or damages of any third party or for lost
     profits or any special, indirect, incidental, consequential or exemplary
     damages, howsoever arising, even if the company has been advised of
     the possibility of such damages.
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