AMERICAN CYANAMID CO LEDERLE LABORATORIES DIV -- NOVANTRONE MITOXANTRONE HCL CONCENTRATE FOR INJECTION,9393 -- 6505-01-292-6658
===================== Product Identification =====================
Product ID:NOVANTRONE MITOXANTRONE HCL CONCENTRATE FOR INJECTION,9393
MSDS Date:04/09/1991
FSC:6505
NIIN:01-292-6658
MSDS Number: BSHPC
=== Responsible Party ===
Company Name:AMERICAN CYANAMID CO LEDERLE LABORATORIES DIV
Address:1 CYANAMID PLZ
City:WAYNE (FORMALLY IN PEARL RIVER,NY,10965)
State:NJ
ZIP:07470
Country:US
Info Phone Num:201-831-2000
Emergency Phone Num:201-831-2000
Preparer's Name:CHARLES S. SCHWARTZ, PHD
CAGE:06404
=== Contractor Identification ===
Company Name:AMERICAN CYANAMID CO LEDERLE LABORATORIES DIV
Address:1 CAMPUS DR
Box:City:PARSIPPANY
State:NJ
ZIP:07054-4404
Country:US
Phone:973-683-2000
CAGE:06404
Company Name:AMERICAN CYANAMID CO LEDERLE LABORATORIES DIV
Address:1 CYANAMID PLZ
Box:City:WAYNE
State:NJ
ZIP:07470
Country:US
Phone:201-831-2000
CAGE:3M726
============= Composition/Information on Ingredients =============
Ingred Name:MITOXANTRONE HCL
CAS:70476-82-3
Fraction by Wt: 0.2%
Other REC Limits:NONE RECOMMENDED
===================== Hazards Identification =====================
LD50 LC50 Mixture:ORAL LD50 (RAT): 682-721 MG/KG
Routes of Entry: Inhalation:YES Skin:YES Ingestion:NO
Reports of Carcinogenicity:NTP:NO IARC:NO OSHA:NO
Health Hazards Acute and Chronic:INHALATION-MILDLY IRRITATING.
INGESTION-MAY CAUSE GI IRRITATION. SKIN-MAY CAUSE IRRITATION.
EYE-IRRITATION. CHRONIC:CARDIOVASCULAR AND BIRTH DEFECTS.
CYTOTOXIC.
Effects of Overexposure:IRRITAION, REDNESS, NAUSEA, VOMITING, LOOSE
STOOL, DIARRHEA, DECREASE WHITE BLOOD CELL COUNT, INCREASED
SUSCEPTIBILITY TO INFECTION.
Medical Cond Aggravated by Exposure:NONE KNOWN.
======================= First Aid Measures =======================
First Aid:EYE-FLUSH PROMPTLY WITH PLENTY OF WATER FOR AT LEAST 15
MINUTES. SKIN-WASH WITH SOAP & WATER; THEN FLUSH WITH WATER UNTIL
CHEMICAL IS REMOVED. INGESTION-IF CONSCIOUS, INDUCE VOMITING AS
DIRECTED BY DO CTOR, IMMEDIATELY GET MEDICAL HELP.
INHALATION-REMOVE TO FRESH AIR. IF BREATHING IS DIFFICULT, GIVE
OXYGEN. GET MEDICAL ATTENTION IF SYMPTOMS PERSIST.
===================== Fire Fighting Measures =====================
Extinguishing Media:USE WATER FOG, CARBON DIOXIDE, FOAM, OR DRY
CHEMICAL.
Fire Fighting Procedures:WEAR FIRE FIGHTING PROTECTIVE EQUIPMENT AND A
FULL FACED SELF CONTAINED BREATHING APPARATUS. COOL FIRE EXPOSED
CONTAINERS WITH WATER SPRAY.
Unusual Fire/Explosion Hazard:COMBUSTION OR HEAT OF FIRE MAY PRODUCE
HAZARDOUS DECOMPOSITION PRODUCTS AND VAPORS.
================== Accidental Release Measures ==================
Spill Release Procedures:WEAR PROTECTIVE EQUIPMENT. WIPE OR MOP UP AND
PLACE IN A CONTAINER FOR DISPOSAL. FLUSH RESIDUE AWAY WITH WATER.
Neutralizing Agent:WATER PLUS DISH SOAP
====================== Handling and Storage ======================
Handling and Storage Precautions:STORE AT 59-86F. DO NOT REFRIGERATE OR
FREEZE. SHELF LIFE FROM DATE OF MFRG IS 2 YRS. PROTECT FROM
PHYSICAL DAMAGE.
Other Precautions:NOVANTRONE CONCENTRATE IS FOR INJECTION ONLY. KEEP
OUT OF REACH OF CHILDREN. FOR THERAPEUTIC USE ONLY.
============= Exposure Controls/Personal Protection =============
Respiratory Protection:NONE NORMALLY REQUIRED. USE NIOSH APPROVED
SELF-CONTAINED BREATHING APPARATUS IF TLV IS EXCEEDED OR WHEN USING
IN CONFINED SPACES.
Ventilation:LOCAL TO CONTROL DUST OR MIST.
Protective Gloves:RUBBER
Eye Protection:SAFETY GOGGLES
Other Protective Equipment:WEAR REGULAR WORK CLOTHES, INCLUDING
LONG-SLEEVED SHIRT & TROUSERS.
Work Hygienic Practices:WASH HANDS, FACE AND EXPOSED BODY PART AT LUNCH
& BREAKS, AND AT END OF SHIFT.
Supplemental Safety and Health
THIS MEDICINE IS USED AS AN ANTICANCER, OCCUPATIONAL HAZARD IS
INVOLVED. TAKE PRECAUTIONS AGAINST OVEREXPOSURE. TOXIC CHLORINE GAS
IS GENERATED WHEN MIXED WITH BLEACH.
================== Physical/Chemical Properties ==================
HCC:N1
Boiling Pt:B.P. Text:212F,100C
pH:3-4.5
Appearance and Odor:STERILE, DARK BLUE SOLUTION, ODORLESS.
================= Stability and Reactivity Data =================
Stability Indicator/Materials to Avoid:YES
OXIDIZING AGENTS, LIKE HYPOCHLORITE AND PERMANGANATE.
Stability Condition to Avoid:HIGH HEAT.
Hazardous Decomposition Products:TOXIC OXIDES OF CARBON AND NITROGEN,
ALDEHYDES, KETONES, ORGANIC ACIDS, POSSIBLY HYDROGEN CYANIDE &
HYDROGEN CHLORIDE.
==================== Disposal Considerations ====================
Waste Disposal Methods:DISPOSE OF IN ACCORDANCE WITH APPLICABLE LOCAL,
STATE AND FEDERAL REGULATIONS.
Disclaimer (provided with this information by the compiling agencies):
This information is formulated for use by elements of the Department
of Defense. The United States of America in no manner whatsoever,
expressly or implied, warrants this information to be accurate and
disclaims all liability for its use. Any person utilizing this
document should seek competent professional advice to verify and
assume responsibility for the suitability of this information to their
particular situation.