BRISTOL MYERS SQUIBB CO -- CEENU 10 MG/CAPSULE -- 6505-01-087-6164
===================== Product Identification =====================
Product ID:CEENU 10 MG/CAPSULE
MSDS Date:03/01/1990
FSC:6505
NIIN:01-087-6164
MSDS Number: BNTQG
=== Responsible Party ===
Company Name:BRISTOL MYERS SQUIBB CO
Address:2400 W LLYOD EXPY
City:EVANSVILLE
State:IN
ZIP:47721
Country:US
Info Phone Num:812-429-5678; 812-429-5644
Emergency Phone Num:812-429-5000
Preparer's Name:MEDICAL SERVICES
CAGE:IO660
=== Contractor Identification ===
Company Name:BRISTOL MYERS SQUIBB
Box:191
City:NEW BRUNSWICK
State:NJ
ZIP:08903
Country:US
Phone:201-519-2885
CAGE:IO660
Company Name:BRISTOL-MYERS US PHARMACEUTICAL & NUTRITIONAL GP.
Address:2400 W LLOYD EXPY
Box:City:EVANSVILLE
State:IN
ZIP:47721-0001
Country:US
Phone:812-429-5644
CAGE:29398
============= Composition/Information on Ingredients =============
Ingred Name:UREA, 1-(2-CHLOROETHYL)-3-CYCLOHEXYL-1-NITROSO-; (CCNU).
LD50: (ORAL, RAT) 70 MG/KG.
CAS:13010-47-4
RTECS #:YS4900000
Fraction by Wt: 4.5%
Ingred Name:SUPP DATA: STAFF MEMBERS WHO ARE PREGNANT, ARE
BREASTFEEDING, OR WHO ARE CONCERNED W/OTHER REPROD ISSUES SHLD BE
(ING 3)
RTECS #:9999999ZZ
Ingred Name:ING 2: ENCOURAGED TO CONSULT W/THE OCCUP HLTH MD MONITORING
WORKERS' HLTH. FEDERAL LAW PROHIBITS DISPENSING (ING 4)
RTECS #:9999999ZZ
Ingred Name:ING 3: WITHOUT PRESCRIPTION. SEE PACKAGE INSERT FOR
RECOMMENDED MEDICAL USE.
RTECS #:9999999ZZ
Ingred Name:HYGIENE PRACT: PREPARATION AREA SHOULD BE FORBIDDEN.
RTECS #:9999999ZZ
===================== Hazards Identification =====================
LD50 LC50 Mixture:SEE INGREDIENT 1
Routes of Entry: Inhalation:YES Skin:YES Ingestion:YES
Reports of Carcinogenicity:NTP:YES IARC:YES OSHA:NO
Health Hazards Acute and Chronic:ACUTE: INGEST: CYTOTOXIC AGENT.
IMPORTANT DOSE-DEPENDENT EFFECTS INCLUDE: HEMOTOLOGIC, HEPATIC,
LUNG & KIDNEY TOXICITY. INHAL: UNKNOWN. SKIN: MAY BE ABSORBED THRU
SKIN. POSSIBLE RASH UPON CONTACT. EYE CONTACT: MAY CAUSE
CONJUNCTIVITIS. CHRONIC: POTENTIAL CARCINOGEN.
Explanation of Carcinogenicity:CCNU: GROUP 2 (NTP), GROUP 2A (IARC).
Effects of Overexposure:SEE HEALTH HAZARD.
Medical Cond Aggravated by Exposure:NONE SPECIFIED BY MANUFACTURER.
======================= First Aid Measures =======================
First Aid:EYES: WASH WITH COPIOUS AMOUNTS OF WATER FOR A MINIMUM OF 15
MINUTES AND IMMEDIATELY SEEK MEDICAL ATTENTION. SKIN: WASH AFFECTED
AREA IMMEDIATELY WITH SOAP & WATER. INGEST/INHAL: SEEK PROFESSIONAL
MED ICAL ATTENTION IF APPROPRIATE.
===================== Fire Fighting Measures =====================
Extinguishing Media:CO*2, DRY CHEMICAL.
Fire Fighting Procedures:WEAR NIOSH/MSHA APPROVED SCBA & FULL
PROTECTIVE EQUIPMENT .
Unusual Fire/Explosion Hazard:UNKNOWN. DOES NOT SUPPORT COMBUSTION.
================== Accidental Release Measures ==================
Spill Release Procedures:PICK UP INTACT CAPSULES. IF CAPSULES ARE
CRUSHED, WIPE SOLID WITH WET ABSORBENT GAUZE OR TOWELS.
Neutralizing Agent:NONE SPECIFIED BY MANUFACTURER.
====================== Handling and Storage ======================
Handling and Storage Precautions:AVOID EXCESSIVE HEAT (OVER 40C). STORE
AT ROOM TEMPERATURE. SEE OSHA INSTRUCTION PUB 8-1.1 FOR ADDL WORK
PRACTICE QUIDELINES FOR HANDLING THIS MATL.
Other Precautions:PRE-PLACEMENT PHYSICAL EXAM & HISTORY (NOTING ANY
RISK FACTORS) FOR EMPLOYEES W/POTNTL EXPOS TO CEENU IS RECOMMENDED.
A COMPLETE BLOOD COUNT, INCL DIFFERENTIAL, MAY BE TAKEN TO PROVIDE
A BASELINE. PER IODIC FOLLOW-UP EXAMINATIONS (SUPP DATA)
============= Exposure Controls/Personal Protection =============
Respiratory Protection:RESPIRATORY PROTECTION WITH NIOSH/MSHA APPRVD
DUST RESPIRATOR, HIGH EFFICIENCY DUST FILTER OR POWERED
AIR-PURIFYING RESPIRATOR IF BSC OR SUITABLE VENTILATION IS NOT
AVAILABLE AND A NUMBER OF CAPSULES ARE TO BE OPENED.
Ventilation:BIOLOGICAL SAFETY CABINET OR LABORATORY EXHAUST HOOD IF
CAPSULES ARE TO BE OPENED.
Protective Gloves:DISPOSABLE LATEX GLOVES.
Eye Protection:CHEMICAL WORKERS GOGGLES .
Other Protective Equipment:PROT DISPOSABLE GOWN OF LOW PERMEABILITY
FABRIC W/CLOSED FRONT, LONG SLEEVES/ELASTIC CUFFS IF CAPSULES ARE
TO BE OPENED.
Work Hygienic Practices:WASH THORO BEFORE EATING/SMKG. EATING/DRINKING/
SMKG/CHEWING GUM/APPLYING COSMETICS OR STORING FOOD NEAR (ING 5)
Supplemental Safety and Health
CNDTNS (STAB): AVOID EXCESSIVE HEAT (OVER 40C). OTHER PREC: SHLD BE
GIVEN I/A/W INSTITUTIONAL POLICY, OVERSEEN BY MD THORO
KNOWLEDGEABLE ABOUT BOTH THE TOXICITY OF THE SUBSTANCE AND THE
EXTENT OF WORK PLACE EXPOSURE. A PERMANENT REGISTRY OFALL STAFF WHO
ROUTINELY PREPARE OR ADMINISTER CEENU SHLD BE CONSIDERED. (ING 2)
================== Physical/Chemical Properties ==================
Melt/Freeze Pt:M.P/F.P Text:194F,90C
Solubility in Water:INSOLUBLE
Appearance and Odor:YELLOW POWDER IN CAPSULES.
================= Stability and Reactivity Data =================
Stability Indicator/Materials to Avoid:YES
NO KNOWN HAZARDOUS INCOMPATIBILITIES.
Stability Condition to Avoid:WHEN STORED AT ROOM TEMP IN ORIGINAL
CONTR, CMPD IS STABLE TO EXPIRATION DATE INDICATED ON LABEL OF
PROD. (SUPP DATA)
Hazardous Decomposition Products:UNKNOWN, BUT ASSUME A CARCINOGENIC
POTENTIAL.
==================== Disposal Considerations ====================
Waste Disposal Methods:TREAT PRODUCT AND CONTAMINATED MATERIALS AS
HAZARDOUS WASTE. INCINERATION IS RECOMMENDED. DISPOSAL MUST BE IN
ACCORDANCE WITH FEDERAL, STATE, AND LOCAL REGULATIONS .
Disclaimer (provided with this information by the compiling agencies):
This information is formulated for use by elements of the Department
of Defense. The United States of America in no manner whatsoever,
expressly or implied, warrants this information to be accurate and
disclaims all liability for its use. Any person utilizing this
document should seek competent professional advice to verify and
assume responsibility for the suitability of this information to their
particular situation.