Cefmetazolum [INN-Latin]

UPJOHN CO THE -- 51871 ZEFAZONE IV SOLUTION -- 6505-00F038039
=====================  Product Identification  =====================

Product ID:51871 ZEFAZONE IV SOLUTION
MSDS Date:06/30/1994
FSC:6505
NIIN:00F038039
MSDS Number: BWKMC
=== Responsible Party ===
Company Name:UPJOHN CO THE
Address:7171 PORTAGE RD
City:KALAMAZOO
State:MI
ZIP:49001-0199
Country:US
Info Phone Num:616-385-7358
Emergency Phone Num:616-323-7555(D)/616-323-5122(24 HR)
CAGE:GO374
=== Contractor Identification ===
Company Name:PHARMACIA & UPJOHN
Address:7171 PORTAGE RD
Box:City:KALAMAZOO
State:MI
ZIP:49001-0199
Country:US
Phone:616-833-5122/616-833-7555
CAGE:93703
Company Name:UPJOHN CO THE
Address:7171 PORTAGE RD
City:KALAMAZOO
State:MI
ZIP:49001-0199
Country:US
Phone:616-323-7555
CAGE:GO374

=============  Composition/Information on Ingredients  =============

Ingred Name:WATER
CAS:7732-18-5
RTECS #:ZC0110000
Fraction by Wt: <95%

Ingred Name:NON HAZARDOUS INGREDIENTS

Ingred Name:CEFMETAZOLE SODIUM	  *94-4*
CAS:56796-39-5
RTECS #:XI0372200
Fraction by Wt: 2-4%

=====================  Hazards Identification  =====================

LD50 LC50 Mixture:ORAL LD50(RAT): 3,204 MG/KG (SEE SUPP)
Routes of Entry: Inhalation:YES  Skin:NO  Ingestion:YES
Reports of Carcinogenicity:NTP:NO    IARC:NO	OSHA:NO
Health Hazards Acute and Chronic:OVEREXPOSURE TO CEFMETAZOLE SOIUM
    COULD CAUSE MILD TO SEVERE ALLERGIC
    REACTIONS/BRONCHOSPASM/ANGIOEDEMA & ANAPHYLAXIS. ALLERGIC REACTIONS
    INCLUDE STEVENS-JOHNSON SYNDROME & ERYTHEMA MULTIFORME. GASTRO
    INTESTINAL EFFECTS. PSEUDOMEMBRANOUS COLITIS MAY RANGE IN SEVERITY
    FROM MILD TO LIFE THREATENING.
Explanation of Carcinogenicity:NONE
Effects of Overexposure:RASH, FEVER, SWELLING, ASTHMATIC BREAHTING,
    HIVES, NAUSEA, VOMITING, DIARRHEA
Medical Cond Aggravated by Exposure:HYPERSENSITIVITY TO
    CEFMETAZOLE/CEPHALOSPORIN GROUP OF ANTIBIOTICS, BETA-LACTAM
    ANTIBIOTICS, RENAL/HEPTATIC IMPAIRMENT, POOR NUTRITIONAL STATE/GI
    DISEASE/CURRENTLY BEING TREATED W/AN AMINOGLYCOSIDE.

=======================  First Aid Measures  =======================

First Aid:EYES: FLUSH W/WATER FOR 15 MINS. SKIN: WASH W/SOAP & WATER.
    INHALATION: REMOVE FROM EXPOSURE. OBTAIN MEDICAL ATTENTION IN ALL
    CASES. NOTES TO PHYSICIAN: IN THE EVENT OF SERIOUS TOXIC REACTIONS
    FROM OV EREXPOSURE, HEMODIALYSIS/PERITONEAL DIALYSIS MAY AID IN THE
    REMOVAL OF CEFMETAZOLE FROM THE BODY, ESPECIALLY IF RENAL FUNCTION
    IS COMPROMISED.

=====================  Fire Fighting Measures  =====================

Flash Point:NONFLAMMABLE
Extinguishing Media:WATER, CO2/DRY CHEMICAL
Fire Fighting Procedures:WEAR SELF CONTAINED BREAHTING APPARATUS & FULL
    BODY PROTECTIVE EQUIPMENT.
Unusual Fire/Explosion Hazard:NONE

==================  Accidental Release Measures  ==================

Spill Release Procedures:PROVIDE VENTILATION & PERSONAL PROTECTION.
    KEEP PRODUCT OUT OF DRAINS; PREVENT ENTRY TO SURFACE
    WATER/GROUNDWATER & SOIL. SMALL: ABSORB W/PAPER TOWELS/OTHER
    APPROPRIATE MEDIA. LARGE: VACUUM/SCOOP & PL ACE IN A SUITABLE
    CONTAINER.

======================	Handling and Storage  ======================

Handling and Storage Precautions:STORE IN A COOL, DRY PLACE & PROTECT
    FROM LIGHT. THE UNDILUTED PRODUCT SHOULD BE STORED IN A CONSTANT
    FREEZER AT -4F.
Other Precautions:KEEP OUT OF REACH OF CHILDREN. AVOID CONTACT W/SKIN,
    EYES & CLOTHING.

=============  Exposure Controls/Personal Protection  =============

Respiratory Protection:NOT REQUIRED.
Ventilation:LOCAL EXHAUST.
Protective Gloves:RUBBER.
Eye Protection:SAFETY GLASSES W/SIDE SHIELDS.
Work Hygienic Practices:REMOVE/LAUNDER CONTAMINATED CLOTHING BEFORE
    REUSE. WASH THOROUGHLY AFTER HANDLING.
Supplemental Safety and Health
ZEFAZONE IV SOLUTION IS A HUMAN DRUG USED IN THE TREATMENT OF SERIOUS
    INFECTIONS INVOLVING THE URINARY TRACT, LOWER RESPITORY TRACT,
    SKIN/SUPPORTING STRUCTURES, INTRAABDOMINAL INFECTIONS & SOME SEXUAL
    LY TRANSMITTED DISEASES. PH: 4.2-6.2 (THAWED). ORAL LD50
    INFORMATION IS FOR: CEFMETAZOLE SODIUM.

==================  Physical/Chemical Properties  ==================

pH:(SUPP)
Solubility in Water:COMPLETE
Appearance and Odor:FROZEN, PREMIXED SOLUTION (W/1-2 G CEFMETAZOLE
    SODIUM) IN 50 ML PLASTIC BAGS.

=================  Stability and Reactivity Data  =================

Stability Indicator/Materials to Avoid:YES
NONE
Stability Condition to Avoid:THAWED- >21 DAYS AT TEMP >46F/>48 HOURS AT
    TEMP >77F.
Hazardous Decomposition Products:CO, CO2, NITROGEN OXIDES, SULFUR
    OXIDES.

====================  Disposal Considerations  ====================

Waste Disposal Methods:DISPOSE OF BY INCINERATION IN ACCORDANCE
    W/LOCAL, STATE & FEDERAL REGULATIONS.

 Disclaimer (provided with this information by the compiling agencies):
 This information is formulated for use by elements of the Department
 of Defense.  The United States of America in no manner whatsoever,
 expressly or implied, warrants this information to be accurate and
 disclaims all liability for its use.  Any person utilizing this
 document should seek competent professional advice to verify and
 assume responsibility for the suitability of this information to their
 particular situation.