Butorfanol [INN-Spanish]

BRISTOL-MEYERS SQUIBB, PHARMACEUTICAL GROUP -- STADOL NASAL SPRAY (10 MG/ML) -- 6505-01-371-8384
=====================  Product Identification  =====================

Product ID:STADOL NASAL SPRAY (10 MG/ML)
MSDS Date:03/27/1992
FSC:6505
NIIN:01-371-8384
MSDS Number: BWZNX
=== Responsible Party ===
Company Name:BRISTOL-MEYERS SQUIBB, PHARMACEUTICAL GROUP
Address:600 COLLEGE RD
City:PRINCETON
State:NJ
ZIP:08543-4500
Country:US
Info Phone Num:609-243-6000
Emergency Phone Num:908-519-2385(CHEMTREC 800-424-9300)
CAGE:0NWX1
=== Contractor Identification ===
Company Name:BRISTOL-MEYERS SQUIBB PHARMACEUTICAL
Address:600 COLLEGE RD E
Box:4500
City:PRINCETON
State:NJ
ZIP:08543
Country:US
Phone:609-243-6102
CAGE:0NWX1
Company Name:BRISTOL-MYERS SQUIBB PHARMACEUTICAL CO APOTHECON
Address:600 COLLEGE RD E
Box:4500
City:PRINCETON
State:NJ
ZIP:08543-4500
Country:US
Phone:609-243-6000
CAGE:0MN35

=============  Composition/Information on Ingredients  =============

Ingred Name:BUTORPHANOL TARTRATE (ALT. CAS#S- 54244-71-2; 5496-23-0;
    61005-22-9)
CAS:58786-99-5
RTECS #:QC7795000
Fraction by Wt: 1%
Other REC Limits:NONE RECOMMENDED

Ingred Name:WATER
CAS:7732-18-5
RTECS #:ZC0110000
Fraction by Wt: >1%
Other REC Limits:NONE RECOMMENDED

Ingred Name:BENZETHONIUM CHLORIDE
CAS:121-54-0
RTECS #:BO7180000
Fraction by Wt: <1%
Other REC Limits:NONE RECOMMENDED

Ingred Name:CITRIC ACID
CAS:77-92-9
RTECS #:GE7350000
Fraction by Wt: <1%
Other REC Limits:NONE RECOMMENDED

Ingred Name:SODIUM CHLORIDE
CAS:7647-14-5
RTECS #:VZ4725000
Fraction by Wt: <1%
Other REC Limits:NONE RECOMMENDED

Ingred Name:SODIUM HYDROXIDE (CERCLA)
CAS:1310-73-2
RTECS #:WB4900000
Fraction by Wt: <1%
Other REC Limits:NONE RECOMMENDED
OSHA PEL:2 MG/M3
ACGIH TLV:C 2 MG/M3; 9495
EPA Rpt Qty:1000 LBS
DOT Rpt Qty:1000 LBS

=====================  Hazards Identification  =====================

Routes of Entry: Inhalation:NO	Skin:NO  Ingestion:YES
Reports of Carcinogenicity:NTP:NO    IARC:NO	OSHA:NO
Health Hazards Acute and Chronic:ACUTE:NOT NORMALLY AN INHALATION
    HAZARD;BUT MAY PRODUCE SYMPTOMS SIMILAR TO INGESTION.NO INFORMATION
    AVAILABLE ON DERMAL TOXICITY.INGESTESTION MAY CAUSE CNS EFFECTS,GI
    TRACT EFFECTS,CARDIOVASCULAR EFF ECTS,DERMATOLOGIC
    EFFECTS,RESPIRATORY DEPRESSION.CHRONIC:PROLONGED EXPOSURE MAY LEAD
    PHYSICAL/PHSYCOLOGICAL DEPENDENCE.
Explanation of Carcinogenicity:NO INGREDIENT OF A CONCENTRATION OF 0.1%
    OR GREATER IS LISTED AS A CARCINOGEN OR SUEPECTED CARCINOGEN.
Effects of Overexposure:SEDATION, NAUSEA, CLAMMINESS, SWEATINESS,
    HEADACHE, VERTIGO, DIZZINESS, LETHARGY, CONFUSION, LIGHTHEADEDNESS,
    NERVOUSNESS, EUPHORIA, HALLUCINATIONS, INSOMNIA, PALPITATIONS,
    BRADICARDIA, ABDOMINAL CRAM PS, CONSTIPATION, VOMITING, RASH,
    ITCHING.
Medical Cond Aggravated by Exposure:PHYSICAL DEPENDENCE ON NARCOTICS,
    RESPIRATORY IMPAIRMENT, CORNARY INSUFFICIENCY, HYPERSENSITIVITY TO
    BUTORPHENOL OR BUTORPHENOL SALTS.

=======================  First Aid Measures  =======================

First Aid:EYES-FLUSH WITH LOTS OF WATER FOR 15-20 MINUTES. SKIN-WASH
    WITH SOAP & WATER FOR 15-20 MINUTES. INGESTED-GET IMMEDIATE MEDICAL
    ATTENTION. CONSIDER NALOXONE AS AN ANTIDOTE. INHALED-REMOVE TO
    FRESH AIR.	GIVE ARTIFICIAL RESPIRATION IF NOT BREATHING; OXYGEN IF
    BREATHING DIFFICULT. GET IMMEDIATE MEDICAL ATTENTION.

=====================  Fire Fighting Measures  =====================

Flash Point:NOT AVAILABLE
Extinguishing Media:USE WATER.
Fire Fighting Procedures:WEAR SELF-CONTAINED BREATHING APPARATUS AND
    FULL PROTECTIVE GEAR. COOL FIRE EXPOSED CONTAINERS WITH WATER.
    DIVERT RUNOFF TO A SAFE AREA.
Unusual Fire/Explosion Hazard:NONE SPECIFIED BY MANUFACTURER.

==================  Accidental Release Measures  ==================

Spill Release Procedures:WEAR SUITABLE PROTECTIVE CLOTHING (LATEX
    GLOVES & EYE PROTECTION AS A MINIUMUM). ABSORB ON APPROPRIATE
    ABSORBENT MATERIAL AND PLACE IN A CONTAINER FOR DISPOSAL. SPILL
    AREA SHOULD BE VENTILATED AND DEC ONTAMINATED AFTER MATERIAL
    PICK-UP.
Neutralizing Agent:NONE SPECIFIED BY MANUFACTURER.

======================	Handling and Storage  ======================

Handling and Storage Precautions:STORE IN A COOL, DRY PLACE AT ROOM
    TEMPERATURE.
Other Precautions:PERSONS ALLERGIC TO BUTORPHENOL, BUTORPHENOL SALTS OR
    ANY OTHER INGREDIENTS IN THIS FORMULATION, SHOULD AVOID CONTACT
    WITH THIS SUBSTANCE. INTENDED FOR USE UNDER DIRECTION OF A
    PHYSICIAN AND/OR CONDIT IONS OF USE ON THE LABEL/INSERT.

=============  Exposure Controls/Personal Protection  =============

Respiratory Protection:NONE NORMALLY REQUIRED.
Ventilation:NONE NORMALLY REQUIRED.
Protective Gloves:LATEX.
Eye Protection:GOGGLES WHEN HANDLING BULK QUANTITIES.
Other Protective Equipment:ADDITIONAL PROTECTIVE CLOTHING MAY BE NEEDED
    WHEN HANDLING LARGE QUANTITIES OF PRODUCT OR IF SPLASHING EXISTS.
Work Hygienic Practices:WASH HANDS AFTER HANDLING AND BEFORE EATING,
    DRINKING, OR SMOKING. LAUNDER CONTAMINATED CLOTHES BEFORE REUSE.
Supplemental Safety and Health
PERSONNEL WHO HANDLE THIS SOLUTION IN A MANUFACTURING FACILITY SHOULD
    WEAR PROTECTIVE CLOTHING, INCLUDING IMPERMEABLE GLOVES, EYE
    PROTECTION, AND A GOWN. PERSONNEL IN A CLINICAL FACILITY SHOULD
    WEAR I MPERMEABLE GLOVES & EYE PROTECTION.
    NDCNUMBER:NDC00087-5650-41.

==================  Physical/Chemical Properties  ==================

HCC:T6
Boiling Pt:B.P. Text:212F,100C
Melt/Freeze Pt:M.P/F.P Text:32.0F,0.0C
pH: 5
Solubility in Water:MODERATE
Appearance and Odor:COLORLESS OR NEAR COLORLESS AQUEOUS SOLUTION IN AN
    AMBER GLASS BOTTLE W/PUMP.

=================  Stability and Reactivity Data  =================

Stability Indicator/Materials to Avoid:YES
NONE KNOWN.
Stability Condition to Avoid:NONE SPECIFIED BY MANUFACTURER.
Hazardous Decomposition Products:THERMAL DECOMPOSITION MAY
    PRODUCE-CARBON MONOXIDE,CARBON DIOXIDE,HYDROGEN CHLORIDE,OXIDES OF
    NITROGEN.
Conditions to Avoid Polymerization:WILL NOT OCCUR.

====================  Disposal Considerations  ====================

Waste Disposal Methods:DISPOSE OF IN ACCORDANCE WITH LOCAL, STATE,
    FEDERAL OR HOST COUNTRY ENVIRONMENTAL REGULATIONS.

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 This information is formulated for use by elements of the Department
 of Defense.  The United States of America in no manner whatsoever,
 expressly or implied, warrants this information to be accurate and
 disclaims all liability for its use.  Any person utilizing this
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