PFIZER PFIPHARMECS DIV -- FLUCONAZOLE IV ======================================================= MSDS Safety Information ======================================================= FSC: 6505 NIIN: 01-319-6651 MSDS Date: 07/08/1992 MSDS Num: BWXWS Product ID: FLUCONAZOLE IV MFN: 01 Responsible Party Cage: 5M836 Name: PFIZER INC PFIPHARMECS DIV Address: 235 E 42ND ST 3RD FLOOR City: NEW YORK NY 10017-5703 Info Phone Number: 212-573-2222 Emergency Phone Number: 212-573-2222 Proprietary Ind: Y Review Ind: Y Published: Y ======================================================= Preparer Co. when other than Responsible Party Co. ======================================================= Cage: 5M836 Name: PFIZER INC PFIPHARMECS DIV Address: 235 E 42ND ST 3RD FLOOR City: NEW YORK NY 10017-5703 ======================================================= Contractor Summary ======================================================= Cage: 5M836 Name: PFIZER INC PFIPHARMECS DIV Address: 235 E 42ND ST 3RD FLOOR City: NEW YORK NY 10017-5703 Phone: 212-573-2222 ======================================================= Item Description Information ======================================================= Item Name: FLUCONAZOLE INJECTION Unit of Issue: PG Quantitative Expression: 00000000006EA UI Container Qty: 1 ======================================================= Ingredients ======================================================= Name: *** PROPRIETARY *** ----------------------------- ======================================================= Health Hazards Data ======================================================= LD50 LC50 Mixture: ORAL LD50(MICE/RATS): 1270-1520 MG/KG Route Of Entry Inds - Inhalation: NO Skin: NO Ingestion: YES Carcinogenicity Inds - NTP: NO IARC: NO OSHA: NO Effects of Exposure: INGESTION: BLOOD, LIVER/KIDNEY TEST ABNORMALITIES ARE POSSIBLE AT HIGH DOSES. EYES: LIQUID MAY BE IRRITANT. SKIN: PURE FLUCONAZOLE MAY BE IRRITANT. Explanation Of Carcinogenicity: NONE Signs And Symptions Of Overexposure: NAUSEA, ABDOMINAL PAIN, DIARRHEA, VOMITING, HEADACHE, IRRITATION First Aid: INGESTION: RINSE MOUTH & GIVE WATER TO DILUTE. DON'T INDUCE VOMITING. EYES: RINSE W/WATER FOR 15 MINS. SKIN: WASH W/SOAP & WATER. OBTAIN MEDICAL ATTENTION IN ALL CASES. ======================================================= Handling and Disposal ======================================================= Spill Release Procedures: COLLECT MATERIAL W/ABSORBENTS. FLUSH AREA W/WATER TO REMOVE THE FINAL TRACES. DON'T FLUSH LARGE QUANTITIES OF MATERIAL TO THE SEWER. Waste Disposal Methods: INCINERATE IN AN APPROVED FACILITY. SMALL AMOUNTS MAY BE FLUSHED TO A SANITARY SEWER IN ACCORDANCE W/LOCAL, STATE & FEDERAL REGULATIONS. Handling And Storage Precautions: STORE VIALS BETWEEN 77F & 41F AWAY FROM POISONS. DON'T FREEZE. MATERIAL IS A DRUG INTENDED FOR HUMAN USE. Other Precautions: DON'T MIX W/OTHER IV MEDICATIONS. ======================================================= Fire and Explosion Hazard Information ======================================================= Extinguishing Media: WATER SPRAY, CO2, DRY CHEMICAL Fire Fighting Procedures: TREAT PRIMARY CAUSE OF FIRE. DON'T BREATHE FUMES. ======================================================= Control Measures ======================================================= Respiratory Protection: NONE REQUIRED UNDER NORMAL CONDITIONS. Ventilation: NO SPECIFIC REQUIREMENTS Protective Gloves: REQUIRED Eye Protection: REQUIRED Other Protective Equipment: GLOVES & SPLASH PROOF SAFETY GLASSES SHOULD BE WORN WHEN HANDLING THIS MATERIAL IN BULK/WHEN VIALS ARE DAMAGED. Work Hygienic Practices: REMOVE/LAUNDER CONTAMINATED CLOTHING BEFORE REUSE. ======================================================= Physical/Chemical Properties ======================================================= Spec Gravity: 1.05 PH: 4-8 Solubility in Water: 0.5% Appearance and Odor: LIQUID IN A PLASTIC CONTAINER/GLASS BOTTLE W/NO ODOR ======================================================= Reactivity Data ======================================================= Stability Indicator: YES Stability Condition To Avoid: FREEZING Materials To Avoid: OTHER IV MEDICATIONS Hazardous Decomposition Products: NITROGEN OXIDES Hazardous Polymerization Indicator: NO ======================================================= Toxicological Information ======================================================= ======================================================= Ecological Information ======================================================= ======================================================= MSDS Transport Information ======================================================= ======================================================= Regulatory Information ======================================================= ======================================================= Other Information ======================================================= ======================================================= HAZCOM Label ======================================================= Product ID: FLUCONAZOLE IV Cage: 5M836 Company Name: PFIZER INC PFIPHARMECS DIV Street: 235 E 42ND ST 3RD FLOOR City: NEW YORK NY Zipcode: 10017-5703 Health Emergency Phone: 212-573-2222 Label Required IND: Y Date Of Label Review: 12/16/1998 Status Code: C Label Date: 12/16/1998 Origination Code: G Hazard And Precautions: INGESTION: BLOOD, LIVER/KIDNEY TEST ABNORMALITIES ARE POSSIBLE AT HIGH DOSES. EYES: LIQUID MAY BE IRRITANT. SKIN: PURE FLUCONAZOLE MAY BE IRRITANT. NAUSEA, ABDOMINAL PAIN, DIARRHEA, VOMITING, HEADACHE, IRRITATION ======================================================= Disclaimer (provided with this information by the compiling agencies): This information is formulated for use by elements of the Department of Defense. The United States of America in no manner whatsoever expressly or implied warrants, states, or intends said information to have any application, use or viability by or to any person or persons outside the Department of Defense nor any person or persons contracting with any instrumentality of the United States of America and disclaims all liability for such use. Any person utilizing this instruction who is not a military or civilian employee of the United States of America should seek competent professional advice to verify and assume responsibility for the suitability of this information to their particular situation regardless of similarity to a corresponding Department of Defense or other government situation.