Safety (MSDS) data for diphenhydramine hydrochloride

Safety (MSDS) data for diphenhydramine hydrochloride

Hazard: harmful


    Synonyms: 2-(benzhydryloxy)-N,N-dimethylethylamine hydrochloride, 2-diphenylmethoxy-N,N-dimethylethylamine hydrochloride, benadryl, benzehist, dabylen, dimedrol, dolestan, eldadryl, felben, fenylhist, halbmond, rohydra, valdrene, wehydryl, allergan, allergival, denydryl, resmin, restamin, vena, further systematic and non-systematic names
    Use: antihistamine, sedative, treatment of allergic conjunctivitus, various further medical uses
    Molecular formula: C17N21NO.HCl
    CAS No: 147-24-0
    EINECS No:

Physical data

    Appearance: white crystalline powder
    Melting point: 166 - 169 C
    Boiling point:
    Vapour density:
    Vapour pressure:
    Density (g cm-3):
    Flash point:
    Explosion limits:
    Autoignition temperature:
    Water solubility: substantial


    Stable, but slowly darkens upon exposure to light. Incompatible with strong oxidizing agents.


    Poison. Harmful if swallowed, inhaled or absorbed through the skin. Suspected carcinogen. Experimental teratogen. May be a reproductive hazard.

    Toxicity data
    (The meaning of any toxicological abbreviations which appear in this section is given here.)
    ORL-RAT LD50 500 mg kg-1
    IVN-RAT LD50 35 mg kg-1
    ORL-MUS LD50 114 mg kg-1
    IPR-MAM LD50 80 mg kg-1
    SKN-CHD TDLO 80 mg/kg/6h-i

    Risk phrases
    (The meaning of any risk phrases which appear in this section is given here.)
    R20 R21 R22 R40.

Transport information

    (The meaning of any UN hazard codes which appear in this section is given here.)

Personal protection

    Safety glasses. Minimize contact.

    Safety phrases
    (The meaning of any safety phrases which appear in this section is given here.)

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This information was last updated on April 8, 2005. We have tried to make it as accurate and useful as possible, but can take no responsibility for its use, misuse, or accuracy. We have not verified this information, and cannot guarantee that it is up-to-date.