PHARMACEUTICAL RESOURCES BRANCH, DTP, DCT, NCI -- 249992 AMSACRINE -- 6505-00F052198
===================== Product Identification =====================
Product ID:249992 AMSACRINE
MSDS Date:09/30/1991
FSC:6505
NIIN:00F052198
MSDS Number: CDBDY
=== Responsible Party ===
Company Name:PHARMACEUTICAL RESOURCES BRANCH, DTP, DCT, NCI
Address:EXEC PLAZA N ROOM 818, 6130 EXEC BLVD
City:ROCKVILLE
State:MD
ZIP:20852-5000
Country:US
CAGE:PHARR
=== Contractor Identification ===
Company Name:PHARMACEUTICAL RESOURCES BRANCH, DTP, DCT, NCI
Address:EXEC PLAZA N ROOM 818, 6130 EXEC BLVD
City:ROCKVILLE
State:MD
ZIP:20852-5000
Country:US
CAGE:PHARR
============= Composition/Information on Ingredients =============
Ingred Name:METHANESULFONAMIDE,
N-(4-(9-ACRIDINYLAMINO)-3-METHOXYPHENOL)METHANESULFONAMIDE,
AMSACRINE
CAS:51264-14-3
RTECS #:PB1080000
===================== Hazards Identification =====================
LD50 LC50 Mixture:ORAL LD50(MOUSE): 810 MG/CUM
Routes of Entry: Inhalation:YES Skin:NO Ingestion:YES
Reports of Carcinogenicity:NTP:NO IARC:NO OSHA:NO
Health Hazards Acute and Chronic:POTENTIALLY HARMFUL. CARDIOTOXICITY
WAS NOTED IN 2.3% OF 3200 PATIENTS & WAS ASSOCIATED W/ANTHRACYCLINE
EXPOSURE.
Explanation of Carcinogenicity:NONE
Effects of Overexposure:STOMATITIS, MUCOSITIS, HEPATOXICITY(ELEVATED
TRANSAMINASE, ALKALINE PHOSPHATES, BILIRUBIN), NAUSEA, VOMITING,
DIARRHEA, ALOPECIA, HYPOKALEMIA, SEIZURES.
======================= First Aid Measures =======================
First Aid:EYES: FLUSH W/COPIOUS AMOUNTS OF WATER FOR 15 MINS. SKIN:
WASH W/PLENTY OF SOAP & WATER. INHALATION: REMOVE TO FRESH AIR.
GIVE CPR IF NEEDED. OBTAIN MEDICAL ATTENTION IN ALL CASES.
===================== Fire Fighting Measures =====================
Extinguishing Media:USE MATERIALS APPROPRIATE TO THE SURROUNDING FIRE.
Fire Fighting Procedures:EVAUCATE PERSONNEL TO A SAFE AREA. USE SCBA &
PROTECTIVE CLOTHING.
================== Accidental Release Measures ==================
Spill Release Procedures:EVACUATE AREA. WEAR SCBA, RUBBER BOOTS & HEAVY
RUBBER GLOVES. WEAR DISPOSABLE COVERALLS & DISCARD. SWEEP UP
COMPOUND, PLACE IN A BAG & HOLD FOR WASTE DISPOSAL. AVOID RAISING
DUST. VENTILATE AREA & WAS H AFTER COMPOUND PICKUP IS COMPLETE &
DISPOSE OF.
====================== Handling and Storage ======================
Handling and Storage Precautions:STORE IN TIGHTLY SEALED CONTAINERS.
Other Precautions:THIS MATERIAL SHOULD BE HANDLED ONLY BY THOSE TRAINED
IN THE HANDLING OF POTENTIALLY HAZARDOUS MATERIAL. AVOID CONTACT &
INHALATION. AVOID PROLONGED/REPEATED EXPOSURE.
============= Exposure Controls/Personal Protection =============
Respiratory Protection:WEAR NIOSH/MSHA APPROVED RESPIRATOR.
Ventilation:LABORATORY OPERATIONS: CONDUCT IN A CHEMICAL FUME HOOD,
GLOVE BOX/VENTILATED CABINET EQUIPPED W/MECHANICAL EXHAUST.
Protective Gloves:RUBBER/LATEX WHEN HANDLING
Eye Protection:CHEMICAL SAFETY GOGGLES WHEN HANDLING
Other Protective Equipment:PROTECTIVE LABORATORY COAT/APRON, SAFETY
SHOWER & EYE BATH.
Work Hygienic Practices:REMOVE/LAUNDER CONTAMINATED CLOTHING BEFORE
REUSE. WASH THOROUGHLY AFTER HANDLING.
Supplemental Safety and Health
MELTING POINT: 453.2-456.8F.
================== Physical/Chemical Properties ==================
Melt/Freeze Pt:M.P/F.P Text:(SEE SUPP)
Solubility in Water:<0.1 MG/ML
Appearance and Odor:REDDISH ORANGE POWDER
================= Stability and Reactivity Data =================
Stability Indicator/Materials to Avoid:YES
INCOMPATIBLE W/CHLORIDE IONS.
Hazardous Decomposition Products:CO, CO2 & NITROGEN OXIDES.
==================== Disposal Considerations ====================
Waste Disposal Methods:DISPOSE OF IAW/FEDERAL, STATE & LOCAL
REGULATIONS.
Disclaimer (provided with this information by the compiling agencies):
This information is formulated for use by elements of the Department
of Defense. The United States of America in no manner whatsoever,
expressly or implied, warrants this information to be accurate and
disclaims all liability for its use. Any person utilizing this
document should seek competent professional advice to verify and
assume responsibility for the suitability of this information to their
particular situation.