Adrenaline/Epinephrine
Material Safety Data Sheet
L(-)-Epinephrine, 99%
ACC# 96863
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Section 1 - Chemical Product and Company Identification |
MSDS Name: L(-)-Epinephrine, 99%
Catalog Numbers:
AC204400000, AC204400050, AC204400100
Synonyms:
l-3,4-Dihydroxy-Alpha-(Methylaminomethyl)Benzyl Alcohol; Adrenaline
Company Identification:
Acros Organics N.V.
One Reagent Lane
Fair Lawn, NJ 07410
For information in North America, call: 800-ACROS-01
For emergencies in the US, call CHEMTREC: 800-424-9300
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Section 2 - Composition, Information on Ingredients
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| CAS# |
Chemical Name |
Percent |
EINECS/ELINCS |
| 51-43-4 |
L(-)-Epinephrine |
99 | 200-098-7 |
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Section 3 - Hazards Identification
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EMERGENCY OVERVIEW
Appearance: white to light beige crystalline powder.
Warning! Harmful if swallowed, inhaled, or
absorbed through the skin. Causes eye, skin, and respiratory tract
irritation. May cause central nervous system effects. May cause
central nervous system depression. Light sensitive. Air sensitive.
May cause cardiac disturbances. The toxicological properties of this
material have not been fully investigated.
Target Organs: Central nervous system,
respiratory system, cardiovascular system, eyes, skin.
Potential Health Effects
Eye:
Causes eye irritation. At high concentrations may cause
lacrimation (tearing) and irritation. May cause chemical
conjunctivitis.
Skin:
Causes skin irritation. May be absorbed through the skin in harmful
amounts.
Ingestion:
May cause gastrointestinal irritation with nausea, vomiting and
diarrhea. May cause cardiac disturbances. The toxicological
properties of this substance have not been fully investigated. May
cause central nervous system depression. May be harmful if swallowed.
Inhalation:
May cause respiratory tract irritation. The toxicological properties
of this substance have not been fully investigated. May be harmful if
inhaled. May cause cardiac damage. Can produce delayed pulmonary
edema. Inhalation at high concentrations may cause CNS depression
and asphixiation.
Chronic:
Effects may be delayed.
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Section 4 - First Aid Measures
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Eyes:
Immediately flush eyes with plenty of water for at least 15 minutes,
occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15
minutes while removing contaminated clothing and shoes. Wash clothing
before reuse.
Ingestion:
Never give anything by mouth to an unconscious person. Get medical
aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and
drink 2-4 cupfuls of milk or water.
Inhalation:
Remove from exposure and move to fresh air immediately. If not
breathing, give artificial respiration. If breathing is difficult,
give oxygen. Get medical aid. Do NOT use mouth-to-mouth
resuscitation.
Notes to Physician:
Treat symptomatically and supportively.
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Section 5 - Fire Fighting Measures
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General Information:
As in any fire, wear a self-contained breathing apparatus in
pressure-demand, MSHA/NIOSH (approved or equivalent), and full
protective gear. During a fire, irritating and highly toxic gases
may be generated by thermal decomposition or combustion. Containers
may explode in the heat of a fire. Runoff from fire control or
dilution water may cause pollution.
Extinguishing Media:
In case of fire, use water, dry chemical, chemical foam, or
alcohol-resistant foam. Use water spray to cool fire-exposed
containers.
Flash Point: Not available.
Autoignition Temperature: Not available.
Explosion Limits, Lower:Not available.
Upper: Not available.
NFPA Rating:
(estimated) Health: 2; Flammability: 0; Instability: 1
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Section 6 - Accidental Release Measures
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General Information: Use proper personal protective equipment as indicated
in Section 8.
Spills/Leaks:
Clean up spills immediately, observing precautions in the Protective
Equipment section. Sweep up, then place into a suitable container for
disposal. Provide ventilation. Place under an inert atmosphere.
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Section 7 - Handling and Storage
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Handling:
Wash thoroughly after handling. Avoid contact with eyes, skin, and
clothing. Keep container tightly closed. Avoid ingestion and
inhalation. Store protected from light. Handle under an inert
atmosphere. Store protected from air. Wash clothing before reuse.
Storage:
Keep refrigerated. (Store below 4�C/39�F.) Store in a tightly closed
container. Poison room locked/refrigerator. Do not expose to air.
Store protected from light. Store under an inert atmosphere.
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Section 8 - Exposure Controls, Personal Protection
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Engineering Controls:
Facilities storing or utilizing this material should be equipped
with an eyewash facility and a safety shower. Use adequate general or
local exhaust ventilation to keep airborne concentrations below the
permissible exposure limits.
Exposure Limits
| Chemical Name |
ACGIH |
NIOSH |
OSHA - Final PELs |
| L(-)-Epinephrine
|
none listed
|
none listed
|
none listed
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OSHA Vacated PELs:
L(-)-Epinephrine:
No OSHA Vacated PELs are listed for this chemical.
Personal Protective Equipment
Eyes:
Wear safety glasses and chemical goggles if splashing
is possible.
Skin:
Wear appropriate protective gloves and clothing to
prevent skin exposure.
Clothing:
Wear appropriate protective clothing to minimize
contact with skin.
Respirators:
Wear a NIOSH/MSHA or European Standard EN 149
approved full-facepiece airline respirator in the
positive pressure mode with emergency escape
provisions.
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Section 9 - Physical and Chemical Properties
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Physical State: Crystalline powder
Appearance: white to light beige
Odor: None reported.
pH: Not available.
Vapor Pressure: Not available.
Vapor Density: Not available.
Evaporation Rate:Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point:208-211 deg C
Decomposition Temperature:> 212 deg C
Solubility: slightly soluble
Specific Gravity/Density:Not available.
Molecular Formula:C9H13NO3
Molecular Weight:183.21
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Section 10 - Stability and Reactivity
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Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Incompatible materials, light, exposure to air, excess heat.
Incompatibilities with Other Materials:
Acid chlorides, acids, oxidizing agents.
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, carbon dioxide, nitrogen.
Hazardous Polymerization: Has not been reported.
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Section 11 - Toxicological Information
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RTECS#:
CAS# 51-43-4:
DO2625000
LD50/LC50:
CAS# 51-43-4:
Skin, rat: LD50 = 62
mg/kg;
.
Carcinogenicity:
CAS# 51-43-4:
Not listed by ACGIH, IARC, NTP, or CA Prop 65.
Epidemiology:
No information found
Teratogenicity:
No information found
Reproductive Effects:
Adverse reproductive effects have occurred in experimental
animals.
Mutagenicity:
Mutagenic effects have occurred in experimental animals.
Neurotoxicity:
No information found
Other Studies:
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Section 12 - Ecological Information
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Ecotoxicity:
No data available.
No information available.
Environmental:
Terrestrial: No information found in the available literature
however, Epinephrine should be highly mobile in soils, and it may
leach to ground water. However, it is unstable in the presence of
light, heat, air and alkalies so it has the potential to undergo
direct photolysis and various chemical reactions in the soil.
Aquatic Fate: None located in the available literature however,
expected to undergo changes similar to those expected in soil.
Atmospheric Fate: Expected to exist almost entirely in the
particulate phase in ambient air. It has an estimated half-life of
about three hours.
Physical:
No information available.
Other:
No information available.
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Section 13 - Disposal Considerations
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Chemical waste generators must determine whether a discarded chemical is classified
as a hazardous waste.
US EPA guidelines for the classification determination are listed in 40 CFR Parts 261.3.
Additionally, waste generators must consult state and local hazardous waste regulations to
ensure complete and accurate classification.
RCRA P-Series: CAS# 51-43-4: waste number
P042.
RCRA U-Series: None listed.
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Section 14 - Transport Information
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| |
US DOT |
Canada TDG |
| Shipping Name: |
DOT regulated - small quantity provisions apply (see 49CFR173.4) |
TOXIC SOLID ORGANIC NOS (EPINEPHRINE) |
| Hazard Class: |
|
6.1 |
| UN Number: |
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UN2811 |
| Packing Group: |
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II |
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Section 15 - Regulatory Information
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US FEDERAL
TSCA
CAS# 51-43-4 is listed on the TSCA inventory.
Health & Safety Reporting List
None of the chemicals are on the Health & Safety Reporting List.
Chemical Test Rules
None of the chemicals in this product are under a Chemical Test Rule.
Section 12b
None of the chemicals are listed under TSCA Section 12b.
TSCA Significant New Use Rule
None of the chemicals in this material have a SNUR under TSCA.
CERCLA Hazardous Substances and corresponding RQs
CAS# 51-43-4: 1000 lb final RQ; 454 kg final RQ
SARA Section 302 Extremely Hazardous Substances
None of the chemicals in this product have a TPQ.
SARA Codes
CAS # 51-43-4: immediate, delayed.
Section 313
No chemicals are reportable under Section 313.
Clean Air Act:
This material does not contain any hazardous air pollutants.
This material does not contain any Class 1 Ozone depletors.
This material does not contain any Class 2 Ozone depletors.
Clean Water Act:
None of the chemicals in this product
are listed as Hazardous Substances under the CWA.
None of the chemicals in this
product are listed as Priority Pollutants under the CWA.
None of the chemicals in this
product are listed as Toxic Pollutants under the CWA.
OSHA:
None of the chemicals in this product
are considered highly hazardous by OSHA.
STATE
CAS# 51-43-4 can be found on the
following state right to know lists: New Jersey, Pennsylvania,
Massachusetts.
California Prop 65
California No Significant Risk Level:
None of the chemicals in this product are listed.
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols:
T
Risk Phrases:
R 23/24/25 Toxic by inhalation, in contact with skin and if
swallowed.
R 33 Danger of cumulative effects.
R 36/37/38 Irritating to eyes, respiratory system and skin.
Safety Phrases:
S 23 Do not inhale gas/fumes/vapour/spray.
S 26 In case of contact with eyes, rinse immediately with plenty of
water and seek medical advice.
S 36/37/39 Wear suitable protective clothing, gloves and eye/face pr
otection.
S 45 In case of accident or if you feel unwell, seek medical advice
immediately (show the label where possible).
WGK (Water Danger/Protection)
CAS# 51-43-4: 3
Canada - DSL/NDSL
CAS# 51-43-4 is listed on Canada's DSL List.
Canada - WHMIS
This product has a WHMIS classification of D1A, D2B.
This product has been classified in accordance with the hazard
criteria of the Controlled Products Regulations and the MSDS
contains all of the information required by those regulations.
Canadian Ingredient Disclosure List
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Section 16 - Additional Information
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MSDS Creation Date: 9/02/1997
Revision #8 Date: 1/31/2005
The information above is believed to be accurate and represents the best
information currently available to us. However, we make no warranty of
merchantability or any other warranty, express or implied, with respect to
such information, and we assume no liability resulting from its use. Users
should make their own investigations to determine the suitability of the
information for their particular purposes. In no event shall Fisher be liable
for any claims, losses, or damages of any third party or for lost profits
or any special, indirect, incidental, consequential or exemplary
damages, howsoever arising, even if Fisher has been advised of
the possibility of such damages.