AMPH-B
Material Safety Data Sheet
Amphotericin B
ACC# 60942
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Section 1 - Chemical Product and Company Identification |
MSDS Name: Amphotericin B
Catalog Numbers:
BP928 250, BP928-250, BP928250
Synonyms:
Amphotericin Beta; Amphozone; Mysteclin-F.
Company Identification:
Fisher Scientific
1 Reagent Lane
Fair Lawn, NJ 07410
For information, call: 201-796-7100
Emergency Number: 201-796-7100
For CHEMTREC assistance, call: 800-424-9300
For International CHEMTREC assistance, call: 703-527-3887
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Section 2 - Composition, Information on Ingredients
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| CAS# |
Chemical Name |
Percent |
EINECS/ELINCS |
| 1397-89-3 |
Amphotericin B |
app. 100 | 215-742-2 |
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Section 3 - Hazards Identification
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EMERGENCY OVERVIEW
Appearance: yellow solid.
Warning! Prolonged or repeated contact causes
defatting of the skin with irritation, dryness, and cracking. May
cause eye irritation. May cause respiratory and digestive tract
irritation. Light sensitive. May cause kidney damage. Moisture
sensitive. Ingestion may result in an allergic reaction. May cause
adverse reproductive effects based upon animal studies.
Target Organs: Kidneys.
Potential Health Effects
Eye:
May cause eye irritation.
Skin:
May cause skin irritation. Prolonged and/or repeated contact may
cause irritation and/or dermatitis. May cause skin sensitization, an
allergic reaction, which becomes evident upon re-exposure to this
material.
Ingestion:
May cause gastrointestinal irritation with nausea, vomiting and
diarrhea.
Intravenous or intraperitoneal administration of this antifungal
agent may cause various toxic effects including; fever, cardiac
abnormalities, blood abnormalities, muscle and joint pain, and
convulsions. Kidney damage and acidosis may also
Inhalation:
May cause respiratory tract irritation.
Chronic:
Prolonged or repeated skin contact may cause defatting and
dermatitis. Prolonged or repeated exposure may cause adverse
reproductive effects.
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Section 4 - First Aid Measures
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Eyes:
Flush eyes with plenty of water for at least 15 minutes, occasionally
lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Wash clothing before reuse. Flush skin with plenty
of soap and water.
Ingestion:
Do not induce vomiting. If victim is conscious and alert, give 2-4
cupfuls of milk or water. Get medical aid.
Inhalation:
Remove from exposure and move to fresh air immediately. If not
breathing, give artificial respiration. If breathing is difficult,
give oxygen. Get medical aid. Do NOT use mouth-to-mouth
resuscitation. If breathing has ceased apply artificial respiration
using oxygen and a suitable mechanical device such as a bag and a
mask.
Notes to Physician:
Treat symptomatically and supportively.
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Section 5 - Fire Fighting Measures
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General Information:
As in any fire, wear a self-contained breathing apparatus in
pressure-demand, MSHA/NIOSH (approved or equivalent), and full
protective gear. Dusts at sufficient concentrations can form
explosive mixtures with air. Combustion generates toxic fumes.
Extinguishing Media:
For small fires, use water spray, dry chemical, carbon dioxide or
chemical foam.
Flash Point: Not applicable.
Autoignition Temperature: Not applicable.
Explosion Limits, Lower:Not available.
Upper: Not available.
NFPA Rating:
(estimated) Health: 1; Flammability: 0; Instability: 0
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Section 6 - Accidental Release Measures
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General Information: Use proper personal protective equipment as indicated
in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal
container. Clean up spills immediately, observing precautions in the
Protective Equipment section. Avoid generating dusty conditions.
Provide ventilation.
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Section 7 - Handling and Storage
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Handling:
Wash thoroughly after handling. Remove contaminated clothing and
wash before reuse. Use with adequate ventilation. Minimize dust
generation and accumulation. Avoid contact with eyes, skin, and
clothing. Avoid ingestion and inhalation.
Storage:
Do not store in direct sunlight. Store in a cool, dry,
well-ventilated area away from incompatible substances. Keep away
from water.
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Section 8 - Exposure Controls, Personal Protection
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Engineering Controls:
Facilities storing or utilizing this material should be equipped
with an eyewash facility and a safety shower. Use adequate
ventilation to keep airborne concentrations low.
Exposure Limits
| Chemical Name |
ACGIH |
NIOSH |
OSHA - Final PELs |
| Amphotericin B
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none listed
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none listed
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none listed
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OSHA Vacated PELs:
Amphotericin B:
No OSHA Vacated PELs are listed for this chemical.
Personal Protective Equipment
Eyes:
Wear appropriate protective eyeglasses or chemical
safety goggles as described by OSHA's eye and face
protection regulations in 29 CFR 1910.133 or European
Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin
exposure.
Clothing:
Wear appropriate protective clothing to prevent skin
exposure.
Respirators:
Follow the OSHA respirator regulations found in 29
CFR 1910.134 or European Standard EN 149. Use a
NIOSH/MSHA or European Standard EN 149 approved
respirator if exposure limits are exceeded or if
irritation or other symptoms are experienced.
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Section 9 - Physical and Chemical Properties
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Physical State: Solid
Appearance: yellow
Odor: none reported
pH: Not available.
Vapor Pressure: Not available.
Vapor Density: Not available.
Evaporation Rate:Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point:> 170 deg C
Decomposition Temperature:Not available.
Solubility: Insoluble in water.
Specific Gravity/Density:Not available.
Molecular Formula:C47H73NO17
Molecular Weight:923.5075
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Section 10 - Stability and Reactivity
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Chemical Stability:
Stable under normal temperatures and pressures. May decompose on
exposure to moist air or water.
Conditions to Avoid:
High temperatures, light, dust generation, moisture, excess heat.
Incompatibilities with Other Materials:
Strong oxidizing agents.
Hazardous Decomposition Products:
Carbon monoxide, oxides of nitrogen, irritating and toxic fumes and
gases, carbon dioxide.
Hazardous Polymerization: Has not been reported.
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Section 11 - Toxicological Information
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RTECS#:
CAS# 1397-89-3:
BU2625000
LD50/LC50:
CAS# 1397-89-3:
Oral, rat: LD50 =
>5 gm/kg;
.
Carcinogenicity:
CAS# 1397-89-3:
Not listed by ACGIH, IARC, NTP, or CA Prop 65.
Epidemiology:
No information available.
Teratogenicity:
No information available.
Reproductive Effects:
Paternal Effects: Prostate/seminal vesicle/Cowpers
gland/urethra, oral-dog TDLo= 600mg/kg; Spermatogenesis,
intravenous-rabbit TDLo= 20mg/kg.
Mutagenicity:
Please refer to RTECS# BU2625000 for specific information.
Neurotoxicity:
No information available.
Other Studies:
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Section 12 - Ecological Information
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Ecotoxicity:
No data available.
No information available.
Environmental:
No information reported.
Physical:
No information available.
Other:
None.
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Section 13 - Disposal Considerations
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Chemical waste generators must determine whether a discarded chemical is classified
as a hazardous waste.
US EPA guidelines for the classification determination are listed in 40 CFR Parts 261.3.
Additionally, waste generators must consult state and local hazardous waste regulations to
ensure complete and accurate classification.
RCRA P-Series: None listed.
RCRA U-Series: None listed.
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Section 14 - Transport Information
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US DOT |
Canada TDG |
| Shipping Name: |
Not regulated as a hazardous material |
No information available. |
| Hazard Class: |
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| UN Number: |
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| Packing Group: |
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Section 15 - Regulatory Information
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US FEDERAL
TSCA
CAS# 1397-89-3 is not listed on the TSCA inventory.
It is for research and development use only.
Health & Safety Reporting List
None of the chemicals are on the Health & Safety Reporting List.
Chemical Test Rules
None of the chemicals in this product are under a Chemical Test Rule.
Section 12b
None of the chemicals are listed under TSCA Section 12b.
TSCA Significant New Use Rule
None of the chemicals in this material have a SNUR under TSCA.
CERCLA Hazardous Substances and corresponding RQs
None of the chemicals in this material have an RQ.
SARA Section 302 Extremely Hazardous Substances
None of the chemicals in this product have a TPQ.
Section 313
No chemicals are reportable under Section 313.
Clean Air Act:
This material does not contain any hazardous air pollutants.
This material does not contain any Class 1 Ozone depletors.
This material does not contain any Class 2 Ozone depletors.
Clean Water Act:
None of the chemicals in this product
are listed as Hazardous Substances under the CWA.
None of the chemicals in this
product are listed as Priority Pollutants under the CWA.
None of the chemicals in this
product are listed as Toxic Pollutants under the CWA.
OSHA:
None of the chemicals in this product
are considered highly hazardous by OSHA.
STATE
CAS# 1397-89-3 is not present on
state lists from CA, PA, MN, MA, FL, or NJ.
California Prop 65
California No Significant Risk Level:
None of the chemicals in this product are listed.
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols:
T
Risk Phrases:
R 25 Toxic if swallowed.
R 36/37/38 Irritating to eyes, respiratory system and skin.
Safety Phrases:
WGK (Water Danger/Protection)
CAS# 1397-89-3: 3
Canada - DSL/NDSL
None of the chemicals in this product are listed on the DSL or NDSL list.
Canada - WHMIS
This product has a WHMIS classification of D2B.
This product has been classified in accordance with the hazard
criteria of the Controlled Products Regulations and the MSDS
contains all of the information required by those regulations.
Canadian Ingredient Disclosure List
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Section 16 - Additional Information
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MSDS Creation Date: 7/13/1999
Revision #3 Date: 10/03/2005
The information above is believed to be accurate and represents the best
information currently available to us. However, we make no warranty of
merchantability or any other warranty, express or implied, with respect to
such information, and we assume no liability resulting from its use. Users
should make their own investigations to determine the suitability of the
information for their particular purposes. In no event shall Fisher be liable
for any claims, losses, or damages of any third party or for lost profits
or any special, indirect, incidental, consequential or exemplary
damages, howsoever arising, even if Fisher has been advised of
the possibility of such damages.