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Zemuron Brand names, Zemuron Analogs

Zemuron Brand Names Mixture

  • No information avaliable

Zemuron Chemical_Formula


Zemuron RX_link


Zemuron fda sheet

Zemuron FDA

Zemuron msds (material safety sheet)

Zemuron MSDS

Zemuron Synthesis Reference

No information avaliable

Zemuron Molecular Weight

416.574 g/mol

Zemuron Melting Point

134.5 oC

Zemuron H2O Solubility

Practically insoluble (22 mg/L)

Zemuron State


Zemuron LogP


Zemuron Dosage Forms

Oral tablets (25 mg, 50 mg, or 100 mg)

Zemuron Indication

Used primarily to treat low-renin hypertension, hypokalemia, and Conn's syndrome.

Zemuron Pharmacology

Spironolactone is a synthetic 17-lactone steroid which is a renal competitive aldosterone antagonist in a class of pharmaceuticals called potassium-sparing diuretics. On its own, spironolactone is only a weak diuretic, but it can be combined with other diuretics. Due to its anti-androgen effect, it can also be used to treat hirsutism, and is a common component in hormone therapy for male-to-female transgendered people. Spironolactone inhibits the effect of aldosterone by competing for intracellular aldosterone receptor in the distal tubule cells. This increases the secretion of water and sodium, while decreasing the excretion of potassium. Spironolactone has a fairly slow onset of action, taking several days to develop and similarly the effect diminishes slowly.

Zemuron Absorption

Fairly rapidly absorbed from the gastrointestinal tract. Food increases the bioavailability of unmetabolized spironolactone by almost 100%.

Zemuron side effects and Toxicity

The oral LD50 of spironolactone is greater than 1,000 mg/kg in mice, rats, and rabbits. Acute overdosage of spironolactone may be manifested by drowsiness, mental confusion, maculopapular or erythematous rash, nausea, vomiting, dizziness, or diarrhea. Spironolactone has been shown to be a tumorigen in chronic toxicity studies in rats.

Zemuron Patient Information

Zemuron Organisms Affected

Humans and other mammals