• Antiparkinson Agents
• Antidyskinetics
• Antiparkinson Agents
• Muscarinic Antagonists
• ATC:N04AA04

• Arpicolin
• Elorine
• Kemadrin
• Kemadrine
• Lergine
• Metanin
• Osnervan
• Prociclidina [Inn-Spanish]
• Procidlidina
• Procyclid
• Procyclidinum [Inn-Latin]
• Procyklidin
• Prosyklidin
• Spamol
• Triciclidina
• Triciloid
• Tricoloid
• Tricyclamol
• Vagosin

C₁₉H₂₉NO

No information avaliable

Adamson, U.S. pat. 2,891,890 (1959 to Burroughs Wellcome)

287.44 g/mol

86 ^oC

Moderately soluble in water, ~ 30 mg/ml

Solid

4.37

Tablet; Elixir

For the treatment of Parkinson's Disease (especially drug induced)

Procyclidine has an atropine-like action. It's antispasmodic effects are thought to be related to the blockage of central cholinergic receptors M1, M2 and M4. It is used to treat symptomatic Parkinsonism and extrapyramidal dysfunction caused by antipsychotic agents.

No information avaliable

LD₅₀=60 mg/kg (IV in mice)

Patient Information:

Follow your doctors instructions for taking this medicine. This medicine can be taken with food or a snack,
to minimize stomach upset. As your body becomes used to the medicine, it should be taken on an empty
stomach. Talk to your doctor about the best time of day to take the medicine. For patients taking the
extended-release forms, swallow the tablet whole, do NOT CRUSH or CHEW. You may break the tablet in half
if the whole pill is too large for you to take.

This medicine can cause dizziness or drowsiness. Be cautious when driving or performing other hazardous
activities. This medicine can impair judgment. Do NOT increase your dose of this medicine without first
talking to your doctor, even if you feel that the medicine is not working.

Discuss the risks and benefits of using this medicine during pregnancy. It is unknown whether this medicine
is excreted in breast milk. DO NOT breastfeed while taking this medicine until you have talked to your
doctor or pediatrician.

Humans and other mammals