Tikosyn
Tikosyn Brand names, Tikosyn Analogs
Tikosyn Brand Names Mixture
- No information avaliable
Tikosyn Chemical_Formula
C19H27N3O5S2
Tikosyn RX_link
http://www.rxlist.com/cgi/generic2/dofetilide.htm
Tikosyn fda sheet
Tikosyn msds (material safety sheet)
Tikosyn Synthesis Reference
No information avaliable
Tikosyn Molecular Weight
441.567 g/mol
Tikosyn Melting Point
No information avaliable
Tikosyn H2O Solubility
No information avaliable
Tikosyn State
Solid
Tikosyn LogP
4.574
Tikosyn Dosage Forms
Capsule
Tikosyn Indication
For the maintenance of normal sinus rhythm (delay in time to recurrence of atrial fibrillation/atrial flutter [AF/AFl]) in patients with atrial fibrillation/atrial flutter of greater than one week duration who have been converted to normal sinus rhythm
Tikosyn Pharmacology
Dofetilide is an antiarrhythmic drug with Class III (cardiac action potential duration prolonging) properties and is indicated for the maintenance of normal sinus rhythm. Dofetilide increases the monophasic action potential duration in a predictable, concentration-dependent manner, primarily due to delayed repolarization. At concentrations covering several orders of magnitude, Dofetilide blocks only IKr with no relevant block of the other repolarizing potassium currents (e.g., IKs, IK1). At clinically relevant concentrations, Dofetilide has no effect on sodium channels (associated with Class I effect), adrenergic alpha-receptors, or adrenergic beta-receptors.
Tikosyn Absorption
>90%
Tikosyn side effects and Toxicity
No information avaliable
Tikosyn Patient Information
No information avaliable
Tikosyn Organisms Affected
Humans and other mammals
