Thiopentobarbituric acid en es it fr

Thiopentobarbituric acid Brand names, Thiopentobarbituric acid Analogs

Thiopentobarbituric acid Brand Names Mixture

  • Thiotal 5g (Thiopental Sodium + Water)

Thiopentobarbituric acid Chemical_Formula


Thiopentobarbituric acid RX_link

Thiopentobarbituric acid fda sheet

Thiopentobarbituric acid msds (material safety sheet)

Thiopentobarbituric acid Synthesis Reference

No information avaliable

Thiopentobarbituric acid Molecular Weight

242.339 g/mol

Thiopentobarbituric acid Melting Point

No information avaliable

Thiopentobarbituric acid H2O Solubility

No information avaliable

Thiopentobarbituric acid State


Thiopentobarbituric acid LogP


Thiopentobarbituric acid Dosage Forms

Powder for solution

Thiopentobarbituric acid Indication

For use as the sole anesthetic agent for brief (15 minute) procedures, for induction of anesthesia prior to administration of other anesthetic agents, to supplement regional anesthesia, to provide hypnosis during balanced anesthesia with other agents for analgesia or muscle relaxation, for the control of convulsive states during or following inhalation anesthesia or local anesthesia, in neurosurgical patients with increased intracranial pressure, and for narcoanalysis and narcosynthesis in psychiatric disorders.

Thiopentobarbituric acid Pharmacology

Thiopental, a barbiturate, is used for the induction of anesthesia prior to the use of other general anesthetic agents and for induction of anesthesia for short surgical, diagnostic, or therapeutic procedures associated with minimal painful stimuli. Thiopental is an ultrashort-acting depressant of the central nervous system which induces hypnosis and anesthesia, but not analgesia. It produces hypnosis within 30 to 40 seconds of intravenous injection. Recovery after a small dose is rapid, with some somnolence and retrograde amnesia. Repeated intravenous doses lead to prolonged anesthesia because fatty tissues act as a reservoir; they accumulate Pentothal in concentrations 6 to 12 times greater than the plasma concentration, and then release the drug slowly to cause prolonged anesthesia

Thiopentobarbituric acid Absorption

Rapidly absorbed.

Thiopentobarbituric acid side effects and Toxicity

Overdosage may occur from too rapid or repeated injections. Too rapid injection may be followed by an alarming fall in blood pressure even to shock levels. Apnea, occasional laryngospasm, coughing and other respiratory difficulties with excessive or too rapid injections may occur. Lethal blood levels may be as low as 1 mg/100 mL for short-acting barbiturates; less if other depressant drugs or alcohol are also present.

Thiopentobarbituric acid Patient Information

When appropriate, patients should be instructed as to the hazards of drowsiness that may follow use of barbiturates. Outpatients should be released in the company of another individual, and no skilled activities, such as operating machinery or driving a motor vehicle, should be engaged in for 8 to 12 hours.

Thiopentobarbituric acid Organisms Affected

Humans and other mammals