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Propycil
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Propycil Brand names, Propycil Analogs

Propycil Brand Names Mixture

  • No information avaliable

Propycil Chemical_Formula

C7H10N2OS

Propycil RX_link

No information avaliable

Propycil fda sheet

Propycil msds (material safety sheet)

Propycil MSDS

Propycil Synthesis Reference

No information avaliable

Propycil Molecular Weight

170.233 g/mol

Propycil Melting Point

219 oC

Propycil H2O Solubility

1200 mg/L

Propycil State

Solid

Propycil LogP

2.055

Propycil Dosage Forms

Tablet (50mg)

Propycil Indication

Used to manage hyperthyroidism which is due to an overactive thyroid gland (Grave's disease).

Propycil Pharmacology

Propylthiouracil is a thiourea antithyroid agent. Grave's disease is the most common cause of hyperthyroidism. It is an autoimmune disease where an individual's own antibodies attach to thyroid stimulating hormone receptors within cells of the thyroid gland and then trigger overproduction of thyroid hormone. The two thyroid hormones manufactured by the thyroid gland, thyroxine (T4) and triiodothyronine (T3), are formed by combining iodine and a protein called thyroglobulin with the assistance of an enzyme called peroxidase. PTU inhibits iodine and peroxidase from their normal interactions with thyroglobulin to form T4 and T3. This action decreases thyroid hormone production. PTU also interferes with the conversion of T4 to T3, and, since T3 is more potent than T4, this also reduces the activity of thyroid hormones. The actions and use of propylthiouracil are similar to those of methimazole.

Propycil Absorption

Well absorbed following oral administration.

Propycil side effects and Toxicity

Oral, rat: LD50 = 1250 mg/kg.

Propycil Patient Information

Take this medicine exactly as directed by your doctor. You may be told to take a higher dose to start, then reduce as your thyroid levels become normal, but your doctor will work out the best dose for you. Propylthiouracil should be taken with a glass of water. The total daily dose may be taken in divided doses over the day or as a single daily dose. Try to get into the habit of taking this medicine at the same times each day to avoid missing any doses. If you forget to take a dose, take it as soon as you remember. Do not take two doses together. If it is almost time to take the next dose, wait until then and then carry on as before. Treatment with propylthiouracil may continue for up to two years. If you suspect that you or someone else has taken an overdose of propylthiouracil contact your doctor or go to the accident and emergency department of your local hospital at once. Always take the container with you if possible, even if it is empty. This medicine is for you. Never give it to others even if their condition appears to be the same as yours.

Propycil Organisms Affected

Humans and other mammals