Phosphonoformic Acid en es it fr

Phosphonoformic Acid Brand names, Phosphonoformic Acid Analogs

Phosphonoformic Acid Brand Names Mixture

  • No information avaliable

Phosphonoformic Acid Chemical_Formula

CH3O5P

Phosphonoformic Acid RX_link

http://www.rxlist.com/cgi/generic2/foscarnet.htm

Phosphonoformic Acid fda sheet

Phosphonoformic Acid msds (material safety sheet)

Phosphonoformic_Acid MSDS

Phosphonoformic Acid Synthesis Reference

Noren, Jan O.; et al., J.Med.Chem. 26(2) 264-270(1983)

Phosphonoformic Acid Molecular Weight

126.005 g/mol

Phosphonoformic Acid Melting Point

88.06 oC

Phosphonoformic Acid H2O Solubility

Complete

Phosphonoformic Acid State

Solid

Phosphonoformic Acid LogP

No information avaliable

Phosphonoformic Acid Dosage Forms

Injection

Phosphonoformic Acid Indication

For the treatment of CMV retinitis in patients with acquired immunodeficiency syndrome (AIDS) and for treatment of acyclovir-resistant mucocutaneous HSV infections in immunocompromised patients.

Phosphonoformic Acid Pharmacology

Foscarnet is an organic analogue of inorganic pyrophosphate that inhibits replication of herpes viruses in vitro including cytomegalovirus (CMV) and herpes simplex virus types 1 and 2 (HSV-1 and HSV-2). Foscarnet does not require activation (phosphorylation) by thymidine kinase or other kinases and therefore is active in vitro against HSV TK deficient mutants and CMV UL97 mutants. Thus, HSV strains resistant to acyclovir or CMV strains resistant to ganciclovir may be sensitive to foscarnet. However, acyclovir or ganciclovir resistant mutants with alterations in the viral DNA polymerase may be resistant to foscarnet and may not respond to therapy with foscarnet. The combination of foscarnet and ganciclovir has been shown to have enhanced activity in vitro.

Phosphonoformic Acid Absorption

Poorly absorbed after oral administration (bioavailability from 12 to 22%).

Phosphonoformic Acid side effects and Toxicity

Oral, rat LD50: >2,000 mg/kg. Signs of overdose include renal impairment.

Phosphonoformic Acid Patient Information

Phosphonoformic Acid Organisms Affected

Human herpes viruses