None
Category
None Brand names, None Analogs
None Brand Names Mixture
None Chemical_Formula
C17H21NO4
None RX_link
http://www.rxlist.com/cgi/generic/cocaine.htm
None fda sheet
None msds (material safety sheet)
None Synthesis Reference
No information avaliable
None Molecular Weight
303.353 g/mol
None Melting Point
195 oC
None H2O Solubility
1800 mg/L
None State
Solid
None LogP
2.393
None Dosage Forms
Liquid
None Indication
For the introduction of local (topical) anesthesia of accessible mucous membranes of the oral, laryngeal and nasal cavities.
None Pharmacology
Cocaine is a local anesthetic indicated for the introduction of local (topical) anesthesia of accessible mucous membranes of the oral, laryngeal and nasal cavities.
None Absorption
Cocaine is absorbed from all sites of application, including mucous membranes and gastrointestinal mucosa. By oral or intra-nasal route, 60 to 80% of cocaine is absorbed.
None side effects and Toxicity
Intense agitation, convulsions, hypertension, rhythm disturbance, coronary insufficiency, hyperthermia, rhabdomyolysis, and renal impairment. Oral mouse LD50 = 96 mg/kg
None Patient Information
No information avaliable
None Organisms Affected
Humans and other mammals
