Nisoldipino [Inn-Spanish]

• Vasodilator Agents
• Antihypertensive Agents
• ATC:C08CA07

• Baymycard
• Nisocor
• Nisoldipin
• Nisoldipine [Usan:Ban:Inn:Jan]
• Nisoldipino [Inn-Spanish]
• Nisoldipinum [Inn-Latin]
• Sular
• Syscor
• Zadipina

• No information avaliable

C₂₀H₂₄N₂O₆

http://www.rxlist.com/cgi/generic/nisoldipine.htm

No information avaliable

388.414 g/mol

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Solid

3.475

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Hypertension

Nisoldipine, a dihydropyridine calcium-channel blocker, is used alone or with an angiotensin-converting enzyme inhibitor, to treat hypertension, chronic stable angina pectoris, and Prinzmetal's variant angina. Nisoldipine is similar to other peripheral vasodilators. Nisoldipine inhibits the influx of extra cellular calcium across the myocardial and vascular smooth muscle cell membranes possibly by deforming the channel, inhibiting ion-control gating mechanisms, and/or interfering with the release of calcium from the sarcoplasmic reticulum. The decrease in intracellular calcium inhibits the contractile processes of the myocardial smooth muscle cells, causing dilation of the coronary and systemic arteries, increased oxygen delivery to the myocardial tissue, decreased total peripheral resistance, decreased systemic blood pressure, and decreased afterload.

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Humans and other mammals