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Mercaptopurine Brand names, Mercaptopurine Analogs

Mercaptopurine Brand Names Mixture

  • No information avaliable

Mercaptopurine Chemical_Formula


Mercaptopurine RX_link

Mercaptopurine fda sheet

Mercaptopurine FDA

Mercaptopurine msds (material safety sheet)

Mercaptopurine MSDS

Mercaptopurine Synthesis Reference

No information avaliable

Mercaptopurine Molecular Weight

152.178 g/mol

Mercaptopurine Melting Point

313 oC

Mercaptopurine H2O Solubility

6.85 mg/mL

Mercaptopurine State


Mercaptopurine LogP


Mercaptopurine Dosage Forms

Tablet (50-mg, scored) for oral administration

Mercaptopurine Indication

For remission induction and maintenance therapy of acute lymphatic leukemia.

Mercaptopurine Pharmacology

Mercaptopurine is one of a large series of purine analogues which interfere with nucleic acid biosynthesis and has been found active against human leukemias. It is an analogue of the purine bases adenine and hypoxanthine. It is not known exactly which of any one or more of the biochemical effects of mercaptopurine and its metabolites are directly or predominantly responsible for cell death.

Mercaptopurine Absorption

Clinical studies have shown that the absorption of an oral dose of mercaptopurine in humans is incomplete and variable, averaging approximately 50% of the administered dose. The factors influencing absorption are unknown.

Mercaptopurine side effects and Toxicity

Signs and symptoms of overdosage may be immediate such as anorexia, nausea, vomiting, and diarrhea; or delayed such as myelosuppression, liver dysfunction, and gastroenteritis. The oral LD50 of mercaptopurine was determined to be 480 mg/kg in the mouse and 425 mg/kg in the rat.

Mercaptopurine Patient Information

No information avaliable

Mercaptopurine Organisms Affected

Humans and other mammals